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| 1 | Iptkalim inhibits cocaine challenge—induced enhancement of dopamine levels in nucleus accumbens and striatum of rats by up—regulating Kir6.1 and Kir6.2 mRNA expression显示文摘AIM:To investigate the effect and mechanism of novel ATP-sensitive potassium channel opener (KCO) iptkalim (IPT) on acute and cocaine challenge-induced alterations in the levels of dopamine (DA) and glutamate (Glu) from nucleus accumbens (NAc), striatum, and prefrontal cortex (PFC) in rats. METHODS: The levels of DA and Glu were assayed using high performance liquid chromatography (HPLC) combined with amperometric and fluorescent detection, respectively. The mRNA levels of Kir6.1, Kir6.2, SUR1, and SUR2 were measured by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). RESULTS: IPT did not affect acute cocaine (30mg/kg,ip)-induced elevations in either DA levels from NAc and striatum or Glu levels from NAc and PFC. An acute cocaine challenge (30mg/kg,ip) on d 21 after withdrawal caused an elevation in DA levels in NAc and striatum. Moreover, the same treatment also increased Gluo levels in PFC and NAc of cocaine-pretreated rats. Repeated IPT injections reversed cocaine challenge-induced DA increase in NAc and striatum. Cocaine challenge increased Kir6.1 and Kir6.2 mRNA expression in striatum and NAc and only elevate Kir6.2 expression in PFC in both cocainepretreated rats and rats pretreated with IPT plus cocaine. Moreover, expression of Kir6.1 and Kir6.2 mRNA was augmented in rats pretreated with IPT plus cocaine compared to rats pretreated with cocaine alone. No significant change was found in the SUR1 and SUR2 expression of all four groups. CONCLUSION:IPT inhibited cocaine challenge-induced enhancement of DA levels in NAc and striatum by up-regulating Kir6.1 and Kir6.2 mRNA expression. | HEHai-Rong DINGJian-Hua GUBing WANGHai HUGang LIUYun | 2003 | Acta Pharmacologica Sinica2003，24，6： | 4 |
| 2 | Monitoring deep convection and convective overshooting with METEOSAT显示文摘 | J. Schmetz S.A. Tjemkes M. Gube L. van de Berg | 1997 | Advances in Space Research1997，，3： | 2 |
| 3 | Determination of 2,5-toluylenediamine (2,5-TDA) and aromatic amines in urine after personal application of hair dyes:kinetics and doses显示文摘 | Schettgen T Heinrich K Kraus T Gube M | | 0，，： | 1 |
| 4 | Biological etfcct markers ira exhaled breath condensale and biomonitoring in welders:impact of smoking and protection equipment 显示文摘 | Gube M Ebel J Brand P | 2010 | Int Arch Occup Environ Health2010，83，7： | 1 |
| 5 | Zur Mischadsorption von Radon an Aktivkohle mit verschiedenen Trager-gasen显示文摘 | Von 0 Gubeli Stori M | 1955 | Helv Chim Acta1955，37，： | 1 |
| 6 | An empirical study of univer- sity spin -off development显示文摘 | Gubeli M H Doloreux D | 2005 | European Journal of In- novation Management2005，8，3： | 1 |
| 7 | Performance of biomarkers SMRP, CAl25, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos显示文摘 | Gube M Taeger D Weber DG | 2011 | Arch Toxicol2011，85，3： | 1 |
| 8 | Monitoring deep convection and convective overshooting with meteosat显示文摘 | Schmetz J Tjemkes S A Gube M | 1997 | Adv Space Res1997，19，3： | 1 |
| 9 | Radiation budget parameters at the top of the Earth's atmosphere derived from METEOSAT data显示文摘 | Gube M | 1982 | Journal of Apphed Meteorology1982，21，： | 1 |
| 10 | Performance of biomarkers SMRP, CA125, and CYFRA 21-1 as potential tumor markers for malignant mesothelioma and lung cancer in a cohort of workers formerly exposed to asbestos 显示文摘 | Gube M Taeger D Weber DG | 2011 | Arch Toxicol2011，85，3： | 1 |
| 11 | Die genuinen glykoside der Blatter und Samen von Digitalis purpurea 显示文摘 | Haack E Kaiser F Gube M | 1956 | Kurze Originalmitteilungen1956，13，43： | 1 |
| 12 | Radiation budget parameters at the top of the Earth's atmosphere derived from METEOSAT data显示文摘 | | 1982 | Journal of Applied Meteorology1982，21，： | 1 |
| 13 | 查看详情显示文摘 | Neil G R Bohn C L Benson S V Biallas G Douglas D Dylla H F Evans R Fugitt J Grippo A Gubeli J Hill R Jordan K Li R Merminga L Piot P Preble J Shinn M Siggins T Walker R Yunn B | | 0，，： | 1 |
| 14 | Detection of overweight and obesity in a national sample of 6 -12 -y -old Swiss children :Accuracy and validity of reference values for body mass index from the US Centers for Disease Control and Prevention and the International Obesity Task Force 显示文摘 | Zimmermann MB Gubeli C Puntener C | 2004 | Am J Clin Nutr2004，79，5： | 1 |
| 15 | Production of high power femtosecond terahertz radia tion 显示文摘 | NEILA G R CARRB G L GUBELI III J F | 2003 | Nuclear Instruments and Methods in Physics Research A2003，807，： | 1 |
| 16 | Biological effect markers in exhaled breath condensate and biomonitoring in welders:impact of smoking and protection equipment显示文摘 | Gube M Ebel J Brand P | 2010 | Int Arch Occup Environ Health2010，83，7： | 1 |
| 17 | Detection of overweight and obesity in a national sample of 6-12-y-old Swiss children: accuracy and validity of reference values for body mass index from the US Centers for Disease Control and Prevention and the International Obesity Task Force 显示文摘 | Zimmermann MB Gubeli C Puntener C | 2004 | Am J Clin Nutr2004，79，5： | 1 |
| 18 | 组织韧性的三个文化维度显示文摘对组织韧性至关重要的三个文化维度:诚信:道德领导力和勇敢坦率;创新:无畏的协同创造力;包容:真正的尊重和归属。三个维度交叉构成了心理安全文化的核心。为了加强韧性,管理者必须了解如何将文化三个孤立维度联系起来,培养鼓励坦诚的领导力素质。本文解释了为什么心理安全对充分实现诚信、创新和包容来说是必要基础,并探索心理安全投资的障碍,进而阐述高层管理者应如何克服障碍以增强韧性。 | Maren Gube | 2023 | 企业家信息2023，，5： | 0 |
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