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| 1 | Iptkalim inhibits cocaine challenge—induced enhancement of dopamine levels in nucleus accumbens and striatum of rats by up—regulating Kir6.1 and Kir6.2 mRNA expression显示文摘AIM:To investigate the effect and mechanism of novel ATP-sensitive potassium channel opener (KCO) iptkalim (IPT) on acute and cocaine challenge-induced alterations in the levels of dopamine (DA) and glutamate (Glu) from nucleus accumbens (NAc), striatum, and prefrontal cortex (PFC) in rats. METHODS: The levels of DA and Glu were assayed using high performance liquid chromatography (HPLC) combined with amperometric and fluorescent detection, respectively. The mRNA levels of Kir6.1, Kir6.2, SUR1, and SUR2 were measured by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). RESULTS: IPT did not affect acute cocaine (30mg/kg,ip)-induced elevations in either DA levels from NAc and striatum or Glu levels from NAc and PFC. An acute cocaine challenge (30mg/kg,ip) on d 21 after withdrawal caused an elevation in DA levels in NAc and striatum. Moreover, the same treatment also increased Gluo levels in PFC and NAc of cocaine-pretreated rats. Repeated IPT injections reversed cocaine challenge-induced DA increase in NAc and striatum. Cocaine challenge increased Kir6.1 and Kir6.2 mRNA expression in striatum and NAc and only elevate Kir6.2 expression in PFC in both cocainepretreated rats and rats pretreated with IPT plus cocaine. Moreover, expression of Kir6.1 and Kir6.2 mRNA was augmented in rats pretreated with IPT plus cocaine compared to rats pretreated with cocaine alone. No significant change was found in the SUR1 and SUR2 expression of all four groups. CONCLUSION:IPT inhibited cocaine challenge-induced enhancement of DA levels in NAc and striatum by up-regulating Kir6.1 and Kir6.2 mRNA expression. | HEHai-Rong DINGJian-Hua GUBing WANGHai HUGang LIUYun | 2003 | Acta Pharmacologica Sinica2003，24，6： | 4 |
| 2 | A Spatiotemporal-Chaos-Based Cryptosystem Taking Advantage of Both Synchronous and Self-Synchronizing Schemes显示文摘Two-dimensional one-way coupled map lattices are used for cryptography where multiple space units producechaotic outputs in parallel. One of the outputs plays the role of driving for synchronization of the decryption sys-tem while the others perform the function of information encoding. With this separation of functions the receivercan establish a self-checking and self-correction mechanism, and enjoys the advantages of both synchronous andself-synchronizing schemes. A comparison between the present system with the system of advanced encryptionstandard (AES) is presented in the aspect of channel noise influence. Numerical investigations show that oursystem is much stronger than AES against channel noise perturbations, and thus can be better used for securecommunications with large channel noise. | LǖHua-Ping WANGShi-Hong LIXiao-Wen TANGGuo-Ning KUANGJin-Yu YEWei-Ping HUGang | 2004 | Chinese Physics Letters2004，21，6： | 2 |
| 3 | Multi-objective optimal reactive power flow incorporating voltage stability显示文摘 | Xiong Hugang Cheng Haozhong | 2006 | WSEAS Transactions on Power Systems2006，3，1： | 1 |
| 4 | Optimal reactive power compensation planning with improving voltage stability margin in deregulated environment显示文摘 | Xiong Hugang Cheng Haozhong Zhang Wenjun | 2006 | WSEAS Transactions on Circuits and Systems2006，5，1： | 1 |
| 5 | Multi-objective optimal reactive power flow incorporating voltage stability显示文摘 | Xiong Hugang Cheng Haozhong | 2006 | WSEAS Transactons on PowerSystems2006，3，1： | 1 |
| 6 | Optimal reactive power compensation planning with improving voltage stability margin in deregulated environment显示文摘 | Xiong Hugang Cheng Haozhong Zhang Wenjun | 2006 | WSEAS Transactions on Circuits and Systems2006，5，1： | 1 |
| 7 | Toll-like Receptor 4 ( TLR4 ) antagonist eritoran tetrasodium attenuates liver ischemia and reperfusion injury through inhibition of high- mobility group box protein B1 ( HMGB1 ) signaling 显示文摘 | MCDONALD K A HUGANG H TOHME S | 2014 | Mol Med2014，20，1： | 1 |
| 8 | Optimal reactive power compensation planning with improving voltage stability margin in deregulated environment显示文摘 | Xiong Hugang Cheng Haozhong Zhang Wenjun | 2006 | WSEAS Trans on Circuits and Systems2006，5，1： | 1 |
| 9 | Optimal reactive power compensation planning with improving vohage stability margin in deregulated environment 显示文摘 | XIONG Hugang CHENG Hao-zhong ZHANG Wen-jun | 2006 | Transactions on Circuits and Systems2006，5，1： | 1 |
| 10 | New method to prepare highperformance isobutylene-isoprene rubber/clay nanocomposites 显示文摘 | TanYingjie(谭英杰) LiangYurong(梁玉蓉) WangLinyan(王林艳) HuGang(胡刚) ZhangTao(张涛) TangGuangdao(唐光道) | 2012 | CIESC Journal2012，63，7： | 1 |
| 11 | A Spatiotemporal-Chaos-Based Encryption Having Overall Properties Considerably Better than Advanced Encryption Standard显示文摘Spatiotemporal chaos of a two-dimensional one-way coupled map lattice is used for chaotic cryptography.The chaotic outputs of many space units are used for encryption simultaneously. This system shows satisfactory cryp-tographie properties of high security, fast encryption (decryption) speed, and robustness against noise disturbances in communication channel. The overall features of this spatiotemporal-chaos-based cryptosystem are better than chaotic cryptosystems known so far, and also than currently used conventional cryptosystems, such as the Advanced Encryption Standard (AES). | WANGShi-Hong YEWei-Ping LOHua-Ping KUANGJin-Yu LIJing-Hua LUOYun-Lun HUGang | 2003 | Communications in Theoretical Physics2003，40，1X： | 1 |
| 12 | The mRNA of the Arabidopsis gene FT moves from leaf to shoot apex and induces flowering 显示文摘 | HUGANG T BOHLENIUS H ERIKSSON S | 2005 | Science2005，309，： | 1 |
| 13 | Studies of ATP sensitive potassium channels on 6 - hydroxydopamine and haloperidol rat models of Parkinson' s disease: Implications for treating Parkinson' s disease?显示文摘Parkinson' s disease is a common neurodegenerative movement disease that affects more than 1% of the elderly population, characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta. Although during the past score, major biochemistry process such as mitochondrial dysfunction, oxidative stress and glutamate | WANGSen YANGYong DINGJian-Hua HUGang | 2004 | 中国药理通讯2004，21，2： | 0 |
| 14 | Beneficial effect of Iptakalim on rotenone-induced Parkinson' s disease model in rats显示文摘Parkinson' s disease (PD) is a common neurodegenerative disorder of unknown etiology, the cardinal features of which include tremor, rigidity, slowness of movement and postural instability. Its pathological hallmarks are the loss of the nigrostriatal dopaminergic neurons and the presence of neuronal proteinacious cytoplasmic inclusions, known as | YANGYong LONGYan DINGJian-Hua HUGang | 2004 | 中国药理通讯2004，21，2： | 0 |
| 15 | Controlling Spiral Waves by Modulations Resonant with the Intrinsic System Mode显示文摘We investigate the spiral wave control in the two-dimensional complex Ginzburg-Landau equation External Drivings which are not resonant with spiral waves but with intrinsic system modes are used to successfully annibilate spiral waves and direct the system to various target states,The novel control mechanism is intuitively explained and the richness and flexibility the control results are | XIAOJing-Hua HUGang HUBam-Bi | 2004 | Chinese Physics Letters2004，21，7： | 0 |
| 16 | Analysis on Technology Implementation and Economic Growth显示文摘 | Shoji Katagiri Hugang Han | 2011 | China-USA Business Review2011，10，8： | 0 |
| 17 | Fusion Reactor and Fusion Reactor Materials:Concept Design of the ITER Test Blanket Modules显示文摘Performances required: prospect to be adopted in DEMO. Shielding for V.V. and TFC in ITER. Design principles: the peak temperature and stress should not exceed technical limits. The structure of test blanket modules (TBM) should be simple for easy fabrication, and TBM should be robust for reliability. | HUANGJinhua LIZaixing ZHUYukun HUGang | 2003 | Southwestern Institute of Physics Annual Report2003，，1： | 0 |
| 18 | Exploratory Study of Blanket Liquid Curtain显示文摘Blankets and other in-vessel components are easily damaged owing to their circumstance of high radiation and high heat. To protect them, first wall design should be considered. Owing to its high heat removal nd self-refreshing capability, liquid metal first wall has been seen as a potential first wall for a fusion reactor in the future. Blanketliquid curtain is actually a special liquid metal wall to protect blanket. | HUGang HUANGJinhua FENGKaiming | 2003 | Southwestern Institute of Physics Annual Report2003，，1： | 0 |
| 19 | Development and validation of a nomogram to predict cardiac death after radiotherapy for esophageal cancer显示文摘Background:Patients frequently die from cardiac causes after radiotherapy for esophageal cancer.Early detection of cardiac death risk in these patients is crucial to improve clinical decision‐making and prognosis.Thus,we modeled the risk of cardiac death after irradiation for esophageal cancer.Methods:A retrospective analysis of 37,599 esophageal cancer cases treated with radiotherapy in the SEER database between 2000 and 2018 was performed.The selected cases were randomly assigned to the model development group(n=26,320)and model validation group(n=11,279)at a ratio of 7:3.We identified the risk factors most commonly associated with cardiac death by least absolute shrinkage and selection operator regression analysis(LASSO).The endpoints for model development and validation were 5‐and 10‐year survival rates.The net clinical benefit of the models was evaluated by decision curve analysis(DCA)and concordance index(C‐index).The performance of the models was further assessed by creating a receiver operating characteristic curve(ROC)and calculating the area under the curve(AUC).Kaplan‐Meier(K‐M)survival analysis was performed on the probability of death.Patients were classified according to death probability thresholds.Five‐and ten‐year survival rates for the two groups were shown using K‐M curves.Results:The major risk factors for cardiac death were age,surgery,year of diagnosis,sequence of surgery and radiotherapy,chemotherapy and a number of tumors,which were used to create the nomogram.The C‐indexes of the nomograms were 0.708 and 0.679 for the development and validation groups,respectively.DCA showed the good net clinical benefit of nomograms in predicting 5‐and 10‐year risk of cardiac death.The model exhibited moderate predictive power for 5‐and 10‐year cardiac mortality(AUC:0.833 and 0.854,respectively),and for the development and validation cohorts(AUC:0.76 and 0.813,respectively).Conclusions:Our nomogram may assist clinicians in making clinical decisions about patients undergoing radiotherapy for esophageal cancer based on early detection of cardiac death risk. | Xinfang Lv Xue Wu Kai Liu Xinke Zhao Chenliang Pan Jing Zhao Juan Chang Huan Guo Xiang Gao Xiaodong Zhi Chunzhen Ren Qilin Chen Hugang Jiang Chunling Wang Ying‐Dong Li | 2023 | Cancer Innovation2023，2，5： | 0 |
| 20 | Flow Analyses of Liquid Metal First Wall显示文摘In fusion reactor design, first wall is one kind of plasma-facing components (PFCs),which will be irradiated by high energy neutrons and other particle, as well as work under high plasma heat flux. They should be considered carefully. Many experiments | HUGang HUANGJinhua | 2002 | Southwestern Institute of Physics Annual Report2002，，1： | 0 |
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