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| 1 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 2 | 腹腔镜结肠癌切除术疗效并不亚于开腹手术——基于COST的5年完整随访资料显示文摘目的通过多中心随机对照试验比较腹腔镜结肠癌切除与开腹手术在切口复发率、无病生存率以及总体生存率等疗效指标上有无差异。方法来自48个不同中心的872名的结肠癌患者被随机分成腹腔镜组和开腹组,分别接受手术治疗。随访8年,其中90%的病例获随访5年以上。主要终点指标为复发时间,分析方法采⒚非劣效性检验,次要终点指标为无病生存率和总体生存率,统计方法采⒚Kaplan-Meier检验。结果截至2007年3月1日,共有170例复发,252例死亡。随访时间为5~10年(中位时间为7年),两组的5年无病生存率(开腹组68.4%,腹腔镜组69.2%,P=0.94)和5年总体生存率(开腹组74.6%,腹腔镜组76.4%,P=0.93)无统计学差异,两组总的复发率无统计学差异(开腹组21.8%,腹腔镜组19.4%,P=0.25)。复发位置分布相似(开腹组:切缘0.5%,肝5.8%,肺4.6%,其它组织8.4%;腹腔镜组:切口0.9%,肝5.5%,肺4.6%,其它组织6.1%)。结论对于可切除的结肠癌而言,腹腔镜手术的效果并不亚于开腹手术。 | 陈志辉 Fleshman J Sargent DJ Green E | 2009 | 中华普通外科学文献(电子版)2009，3，1： | 13 |
| 3 | 吐哈盆地煤成烃研究新进展显示文摘运用生物标记物及碳同位素等地化参数对吐鲁番 -哈密盆地的原油及其源岩进行了油源对比 ,结果将该区原油分为三类 :第一类原油 ,根据生标特征分析其具有显著的淡水环境、藻含量低、细菌影响大、C2 9甾烷含量高、C3 04α 甲基甾烷低、C2 4 四环烷和C19三环烷含量高和碳同位素偏重 (δ13 C为 - 2 5‰~ - 2 7‰ )的特点 ,初步对比结果 ,本区西山窑组的煤是该类原油的主要源岩 ;第二类原油 ,富含藻类物质 (C2 7甾烷与C3 0 4α 甲基甾烷含量较高 ) ,该类原油可能来自侏罗系的富藻湖相泥岩 ;第三类原油 ,全油碳同位素δ13 C为 - 30‰~ - 32‰ ,这类原油的生标反映出其源岩相的特征为缺氧、咸水、中等含藻的湖相沉积 (高含量的伽玛蜡烷和 β 胡萝卜烷 ,C3 5/C3 4藿烷比值大等 )。 | 程克明 熊英 J M Moldowan J Greene Todd | 2002 | 沉积学报2002，20，3： | 10 |
| 4 | 小胶质细胞再激活可缓解脑损伤后炎症反应并促进脑功能恢复显示文摘中枢神经系统疾病或损伤后,小胶质细胞介导的慢性神经炎症反应会损伤局部脑组织,加重病情,不利于神经功能的恢复。小胶质细胞的激活通过集落刺激因子1受体(CSF1R)信号通路,CSF1R抑制剂可阻断小胶质细胞的激活。抑制慢性神经炎症反应是治疗中枢神经系统疾病的有效方法,但长时间抑制小胶质细胞在临床实践中无法实现。值得注意的是,去掉CSF1R抑制剂可刺激中枢神经系统内新的小胶质细胞的彻底重激活。本课题组建立小鼠广泛性神经元丢失模型,在该模型中探讨急性小胶质细胞的消除及再激活的作用。神经元的丢失导致了较长时间的神经炎性反应,表现为小胶质细胞肿胀,并表达CD68和CD45;同时,细胞因子、趋化因子、补体及其他炎症信号的表达增加。小胶质细胞的再激活可以缓解上述炎症反应,还可以促进小鼠神经功能的恢复,即使该小鼠的海马神经元丢失80%,其在水迷宫测试中的得分与正常小鼠的得分相差无几。对突触的分析结果显示,小胶质细胞的再激活可增加PSD95和突触泡蛋白点状突触体的表达,提示小胶质细胞有助于重塑和调节突触的形态和功能。综上所述,本研究结果显示,小胶质细胞的短时间消除及再激活可能是一种新颖有效的方法用于减少神经炎性反应并促进脑功能恢复。 | Rice RA Pham J Lee RJ Najafi AR West BL Green KN 唐颖馨(编译) | 2017 | 神经损伤与功能重建2017，12，3： | 9 |
| 5 | Apoptosis after intestinal ischemia-reperfusion injury显示文摘 | Shah K A Shndra S Green C J | 1997 | Transplantation1997，64，10： | 3 |
| 6 | Recommendations to quantify villous atrophy in video capsule endoscopy images of celiac disease patients显示文摘AIM To quantify the presence of villous atrophy in endoscopic images for improved automation.METHODS There are two main categories of quantitative descriptors helpful to detect villous atrophy:(1) Statistical and(2) Syntactic. Statistical descriptors measure the small intestinal substrate in endoscope-acquired images based on mathematical methods. Texture is the most commonly used statistical descriptor to quantify villous atrophy. Syntactic descriptors comprise a syntax, or set of rules, for analyzing and parsing the substrate into a set of objects with boundaries. The syntax is designed to identify and distinguish three-dimensional structures based on their shape.RESULTS The variance texture statistical descriptor is useful to describe the average variability in image gray level representing villous atrophy, but does not determine the range in variability and the spatial relationships between regions. Improved textural descriptors will incorporate these factors, so that areas with variability gradients and regions that are orientation dependent can be distinguished. The protrusion syntactic descriptor is useful to detect three-dimensional architectural components, but is limited to identifying objects of a certain shape. Improvement in this descriptor will require incorporating flexibility to the prototypical template, so that protrusions of any shape can be detected, measured, and distinguished.CONCLUSION Improved quantitative descriptors of villous atrophy are being developed, which will be useful in detecting subtle, varying patterns of villous atrophy in the small intestinal mucosa of suspected and known celiac disease patients. | Edward J Ciaccio Govind Bhagat Suzanne K Lewis Peter H Green | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 7 | 未控制高血压患者进行家庭血压监测与药剂师管理后的心血管事件及费用显示文摘未控制高血压是心血管病的主要病因。在16家初级保健诊所进行的整群随机试验结果表明:12个月的远程家庭血压监测与药剂师管理可较常规治疗24个月降压幅度更大。该文报道心血管事件(非致死性心肌梗死、非致死性脑卒中、心力衰竭住院、冠状动脉再血管化及心血管病死亡)与随访5年的花费。在远程干预组(TI组,n=228),10例患者发生15次心血管事件(5次心肌梗死、4次脑卒中、5次心力衰竭、1次心血管病死亡)。 | 赵狄(摘译) 刘莉(审校) Margolis KL Dehmer SP Sperl-Hillen J O’Connor PJ Asche SE Bergdall AR Green BB Nyboer RA Pawloski PA Trower NK Maciosek MV | 2020 | 中华高血压杂志2020，28，11： | 3 |
| 8 | Implementation of a polling protocol for predicting celiac disease in videocapsule analysis显示文摘AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image sequences.METHODS: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensitivity occurred for two celiac patients with Marsh type Ⅱ pattern, which is characterized by crypt hyperplasia, but normal villous architecture. Pooled from all levels, there was a mean of 14.31 ± 3.28 automaton votes for celiac vs 9.67 ± 3.31 automaton votes for control when celiac patient data was analyzed (P<0.001). Pooled from all levels, there was a mean of 9.71 ± 2.8128 automaton votes for celiac vs 14.32 ± 2.7931 automaton votes for control when control patient data was analyzed (P<0.001). CONCLUSION: Automata-based polling may be useful to indicate presence of mucosal atrophy, indicative of celiac disease, across the entire small bowel, though this must be confirmed in a larger patient set. Since the method is quantitative and automated, it can potentially eliminate observer bias and enable the detectionof subtle abnormality in patients lacking a clear diagnosis. Our paradigm was found to be more efficacious at proximal small intestinal locations, which may suggest a greater presence and severity of villous atrophy at proximal as compared with distal locations. | Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 3 |
| 9 | A rat model of bone cancer pain显示文摘 | S.J Medhurst K Walker M Bowes B.L Kidd M Glatt M Muller M Hattenberger J Vaxelaire T O’Reilly G Wotherspoon J Winter J Green L Urban | 2002 | Pain2002，，： | 2 |
| 10 | Prosthetic above-knee femoropopliteal bypass grafting: Five-year results of a randomized trial显示文摘 | Richard M Green William M Abbott Teruo Matsumoto Jock R Wheeler Normand Miller Frank J Veith Sam Money H Edward Garrett | 2000 | Journal of Vascular Surgery2000，，： | 2 |
| 11 | Analysis of nitrate,nitrite,andnitrate in biological fluids显示文摘 | Green LC Wagner DA Glogowski J Skipper PL Wishnok JS Tannenbaum SR | 1982 | Anal Biochem1982，126，1： | 2 |
| 12 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders显示文摘 | E Joanna Baxter Linda M Scott Peter J Campbell Clare East Nasios Fourouclas Soheila Swanton George S Vassiliou Anthony J Bench Elaine M Boyd Natasha Curtin Mike A Scott Wendy N Erber Anthony R Green | 2005 | The Lancet . 2005 (9464)2005，，： | 2 |
| 13 | Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis显示文摘 | John A Green John M Kirwan Jayne F Tierney Paul Symonds Lydia Fresco Mandy Collingwood Christopher J Williams | 2001 | The Lancet . 2001 (9284)2001，，： | 2 |
| 14 | Enhancement of iron chelaation by desferrioxamine entrapped in red blood cell ghosts显示文摘 | Green BR Miller J Crosby W | 1981 | Blood1981，57，5： | 2 |
| 15 | Complications neuropathy:pathogenetic considerations显示文摘 | Greene DA Sima AA Stevens M J | | 0，，： | 2 |
| 16 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 17 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 18 | Computing dirichlet tessellations in the plane 显示文摘 | Green P J Sibson R | 1978 | Commputer Journal1978，21，2： | 2 |
| 19 | An inherently linear and compact MOST-only current division technique显示文摘 | Baut K Green J G M | 1992 | IEEE J Sol Sta Circ1992，27，12： | 2 |
| 20 | Detection of airborne cytomegalovirus in hospital room of immuncompromised patients显示文摘 | McCluskey R Sandin R Greene J | 1996 | J Virol Methods1996，56，1： | 1 |
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