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| 1 | Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population显示文摘AIM: To study the association between atrophic gastritis (AG) and esophageal squamous cell carcinoma (ESCC) in a Latin-America population. METHODS: A case-control study was performed at two reference Brazilian hospitals including patients diagnosed with advanced ESCC and dyspeptic patients who had been subjected to upper gastrointestinal endoscopy, with biopsies of the gastric antrum and body.All cases with ESCC were reviewed by a single pathologist, who applied standard criteria for the diagnosis of mucosal atrophy, intestinal metaplasia, and dysplasia, all classified as AG. The data on the patients' age, sex, smoking status, and alcohol consumption were collected from clinical records, and any missing information was completed by telephone interview. The association between AG and ESCC was assessed by means of univariate and multiple conditional logistic regressions. RESULTS: Most patients were male, and the median age was 59 years (range: 37-79 years) in both the ESCC and control groups. Univariate analysis showed that an intake of ethanol greater than 32 g/d was an independent risk factor that increased the odds of ESCC 7.57 times (P = 0.014); upon multiple analysis, alcohol intake of ethanol greater than 32 g/d exhibited a risk of 4.54 (P = 0.081), as adjusted for AG and smoking. Smoking was shown to be an independent risk factor that increased the odds of ESCC 14.55 times (P = 0.011) for individuals who smoked 0 to 51 packs/year and 21.40 times (P = 0.006) for those who smoked more than 51 packs/year. Upon multiple analyses, those who smoked up to 51 packs/year exhibited a risk of 7.85 (P = 0.058), and those who smoked more than 51 packs/ year had a risk 11.57 times higher (P = 0.04), as adjusted for AG and alcohol consumption. AG proved to be a risk factor that increased the odds of ESCC 5.33 times (95%CI: 1.55-18.30, P = 0.008) according to the results of univariate conditional logistic regression. CONCLUSION: There was an association by univariate conditional logistic regression between AG and ECSS in this sample of Latin-American population. | Emiliano de Carvalho Almodova Walmar Kerche de Oliveira Lucas Faria Abraho Machado Juliana Rigotto Grejo Thiago Rabelo da Cunha Wagner Colaiacovo Erika Veruska Paiva Ortolan | 2013 | World Journal of Gastroenterology2013，19，13： | 5 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Engineering Improved Photosynthesis in the Era of Synthetic Biology显示文摘Much attention has been given to the enhancement of photosynthesis as a strategy for the optimization of crop productivity.As traditional plant breeding is most likely reaching a plateau,there is a timely need to accelerate improvements in photosynthetic efficiency by means of novel tools and biotechnological solutions.The emerging field of synthetic biology offers the potential for building completely novel pathways in predictable directions and,thus,addresses the global requirements for higher yields expected to occur in the 21st century.Here,we discuss recent advances and current challenges of engineering improved photosynthesis in the era of synthetic biology toward optimized utilization of solar energy and carbon sources to optimize the production of food,fiber,and fuel. | Willian Batista-Silva Paula da Fonseca-Pereira Auxiliadora Oliveira Martins Agustin Zsogon Adriano Nunes-Nesi Wagner L.Araujo | 2020 | Plant Communications2020，1，2： | 2 |
| 4 | Analysis of nitrate,nitrite,andnitrate in biological fluids显示文摘 | Green LC Wagner DA Glogowski J Skipper PL Wishnok JS Tannenbaum SR | 1982 | Anal Biochem1982，126，1： | 2 |
| 5 | Prediction of the extent and severity of left ventricular dysfunction in anterior acute myocardial infarction by the admission electrocardiogram 显示文摘 | Birnbaum Y Criger DA Wagner GS | 2001 | Am Heart J2001，141，6： | 1 |
| 6 | Phylogeny of dissimilatory sulfite reductases supports an erly origin of sulfate respiration 显示文摘 | Wagner M Roger A J Flax JL Brusseau GA Stahl DA | 1998 | JBacteriol1998，180，： | 1 |
| 7 | Analysis of nitrate, nitrite, and nitrate in biological fluids 显示文摘 | Green LC Wagner DA Glogowski J | 1992 | Anal Biochem1992，126，： | 1 |
| 8 | Analysis of nitrate,and (15N) nitrite in biological fluids显示文摘 | Wagner DA Glogpwski J | 1982 | Anal Biochem1982，126，： | 1 |
| 9 | Analysis of nitrate, nitrite, and nitrate in biological fluids 显示文摘 | Green LC Wagner DA Glogowski J Skipper PL Wishnok JS Tannenbaum SR | 1982 | Anal Biochem1982，126，1： | 1 |
| 10 | Lack of antigen-specific Thl response alters granuloma formation and composition in Schistosoma mansoni-infected MyD88-/- mice显示文摘 | Layland LE Wagner H da Costa CU | 2005 | Eur J lmmunol2005，35，11： | 1 |
| 11 | Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L.显示文摘 | Gabrieli Penha Bezerra Roberto Wagner da Silva Góis Teresinha Silva de Brito Francisco José Batista de Lima Mary Anne Medeiros Bandeira Nirla Rodrigues Romero Pedro Jorge Caldas Magalh?es Gilvandete Maria Pinheiro Santiago | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 12 | Evaluation of serum and pleural levels of the tumor markers CEA, CYFRA21-1 and CA 15-3 in pa- tients with pleural effusion显示文摘 | WAGNER I C GUIMARAES M J DA SILVA L K | 2007 | J Bras Pneumol2007，33，： | 1 |
| 13 | Rituximab-induced interstitial lung disease显示文摘 | Wagner SA Mehta AC Laber DA | 2007 | Am J Hematol2007，82，10： | 1 |
| 14 | Branched-chain amino acid interactions with reference to amino acid requirements in adult men:valine metabolism at different leucine intakes显示文摘 | Marks L Wagner DA | 1991 | Am J Clin Nutr1991，54，2： | 1 |
| 15 | Analysis of nitrate,nitrite, and nitrate in biological fluids显示文摘 | Green LC Wagner DA Skipper PL | 1982 | Anal Biochem1982，126，1： | 1 |
| 16 | Prediction of the extent and severity of left ventricular dysfunction in anterior acute myocardial infarction by the admission electrocardiogram显示文摘 | Birnbaum Y Criger DA Wagner GS | 2001 | Am Heart J2001，141，6： | 1 |
| 17 | Relation between solubility and surface hydrophobicity as an indicator of modifications during preparation proeesses of eommereial and laboratory-prepared soy protein isolates显示文摘 | Wagner JR Sorgentini DA Anon MC | 2000 | Journal of Agrieultural and Food Chemistry2000，48，8： | 1 |
| 18 | Analysis of nitrate, nitrite,and nitrate in biological fluids显示文摘 | Green LC Wagner DA Glogowski J | 1982 | Anal Biochem1982，126，： | 1 |
| 19 | Prediction of the extent and severity of left ventrioular dysfunction in anterior acute myocardial infarction by the admission electrocardiogram显示文摘 | Binbaum Y Criger DA Wagner GS | 2001 | Am Heart J2001，141，6： | 1 |
| 20 | Evalua-tion of serum and pleural levels of the tumor markersCEA,CYFRA21-1and CA 15-3in patients with pleuraleffusion显示文摘 | Wagner IC Guimarfies MJ Da Silva LK et a1 | 2007 | J Bras Pneumol2007，33，2： | 1 |
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