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| 1 | Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage显示文摘Spontaneous intracerebral hemorrhage is a type of stroke associated with poor outcomes. Mortality is elevated, especially in the acute phase. From a pathophysiological point of view the bleeding must traverse different stages dominated by the possibility of re-bleeding, edema, intracranial hypertension, inflammation and neurotoxicity due to blood degradation products, mainly hemoglobin and thrombin. Neurological deterioration and death are common in early hours, so it is a true neurologicalneurosurgical emergency. Time is brain so that action should be taken fast and accurately. The most significant prognostic factors are level of consciousness, location, volume and ventricular extension of the bleeding. Nihilism and early withdrawal of active therapy undoubtedly influence the final result. Although there are no proven therapeutic measures, treatment should be individualized and guided preferably by pathophysiology. The multidisciplinary teamwork is essential. Results of recently completed studies have birth to promising new strategies. For correct management it's important to establish an orderly and systematic strategy based on clinical stabilization, evaluation and establishment of prognosis, avoiding secondary insults and adoption of specific individualized therapies, including hemostatic therapy and intensive control of elevated blood pressure. Uncertainty continues regarding the role of surgery. | Daniel Agustin Godoy Gustavo Rene Pi?ero Patricia Koller Luca Masotti Mario Di Napoli | 2015 | World Journal of Critical Care Medicine2015，4，3： | 14 |
| 2 | Topology-Based Recommendation of Users in Micro-Blogging Communities显示文摘Nowadays,more and more users share real-time news and information in micro-blogging communities such as Twitter,Tumblr or Plurk.In these sites,information is shared via a followers/followees social network structure in which a follower will receive all the micro-blogs from the users he/she follows,named followees.With the increasing number of registered users in this kind of sites,finding relevant and reliable sources of information becomes essential.The reduced number of characters present in micro-posts along with the informal language commonly used in these sites make it difficult to apply standard content-based approaches to the problem of user recommendation.To address this problem,we propose an algorithm for recommending relevant users that explores the topology of the network considering different factors that allow us to identify users that can be considered good information sources.Experimental evaluation conducted with a group of users is reported,demonstrating the potential of the approach. | Marcelo G.Armentano Daniela Godoy Analía Amandi | 2012 | Journal of Computer Science & Technology2012，27，3： | 8 |
| 3 | User profiling in personal inform- ation agents: a survey 显示文摘 | Godoy D Amandi A | 2006 | The Knowledge Engineering Review2006，20，4： | 7 |
| 4 | Relationship between Physical and Chemical Soil Attributes and Plant Species Diversity in Tropical Mountain Ecosystems from Brazil显示文摘Although the high diversity of plant species in the rupestrian fields has been primarily attributed to the existence of a set of distinct habitats, few studies support this assertion. The present study aimed to further investigate the relationship between physical and chemical attributes of soils with the diversity of plant species in this unique ecosystem. The rupestrian field is a unique vegetation formation that covers some of the southeastern Brazilian mountains in the transition of the Atlantic rain forest and the Cerrado(savanna). Different habitats occur according to soil characteristics(e.g., presence of rocks, sand, fertility, hydrology, etc.). These attributes ultimately influence the vegetation that is highly adapted to the harsh edaphic and climatic mountain conditions. Five distinct habitats were studied by us: rocky outcrops, peat bogs, sandy bogs, quartz gravel fields, and 'cerrado'(savanna). A floristic survey indicated that four families are found at greater frequency: Poaceae, Asteraceae, Cyperaceae, and Leguminosae. The greatest diversity of plant species was found in the rocky outcrops habitat, followed by cerrado, peat bog, quartz gravel grassland, and sandy bogs, respectively. The main difference in the floristic composition among these habitats was related to the dominant species. Trachypogon spicatus(Poaceae) was the most dominant species in the rocky outcrops, Axonopus siccus(Poaceae) in the peat bogs, Lagenocarpus rigidus(Cyperaceae) in the sandy bogs, Schizachyrium tenerum(Poaceae) in the cerrado, while Vellozia sp. 8(Velloziaceae) dominated the vegetation in the quartz gravel grassland. This study demonstrated that physical and chemical soil properties strongly related the diversity of plant species occurring in the different habitats of rupestrian fields. | Ferna de CARVALHO Edward Luis GODOY Francy J. G. LISBOA Fatima Maria de Souza MOREIRA Francisco Adriano de SOUZA Ricardo Luis Louro BERBARA G Wilson FERNES | 2014 | Journal of Mountain Science2014，11，4： | 7 |
| 5 | Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection显示文摘Hepatitis delta virus(HDV) seems to strongly suppress hepatitis B virus(HBV)replication, although little is known about the mechanism of this interaction. Both these viruses show a dynamic distribution of mutants, resulting in viral quasispecies. Next-generation sequencing is a viable approach for analyzing the composition of these mutant spectra. As the regulatory hepatitis B X protein(HBx) is essential for HBV replication, determination of HBV X gene(HBX)quasispecies complexity in HBV/HDV infection compared to HBV monoinfection may provide information on the interactions between these two viruses.AIM To compare HBV quasispecies complexity in the HBX 5' region between chronic hepatitis delta(CHD) and chronic HBV mono-infected patients.METHODS Twenty-four untreated patients were included: 7/24(29.2%) with HBeAgnegative chronic HBV infection(CI, previously termed inactive carriers), 8/24(33.3%) with HBeAg-negative chronic hepatitis B(CHB) and 9/24(37.5%) with CHD. A serum sample from each patient was first tested for HBV DNA levels.The HBX 5' region [nucleotides(nt) 1255-1611] was then PCR-amplified for subsequent next-generation sequencing(MiSeq, Illumina, United States). HBV quasispecies complexity in the region analyzed was evaluated using incidencebased indices(number of haplotypes and number of mutations), abundancebased indices(Hill numbers of order 1 and 2), and functional indices(mutation frequency and nucleotide diversity). We also evaluated the pattern of nucleotide changes to investigate which of them could be the cause of the quasispecies complexity.RESULTS CHB patients showed higher median HBV-DNA levels [5.4 logIU/mL,interquartile range(IQR) 3.5-7.9] than CHD(3.4 logIU/mL, IQR 3-7.6)(P = n.s.)or CI(3.2 logIU/mL, IQR 2.3-3.5)(P < 0.01) patients. The incidence and abundance indices indicated that HBV quasispecies complexity was significantly greater in CI than CHB. A similar trend was observed in CHD patients, although only Hill numbers of order 2 showed statistically significant differences(CHB2.81, IQR 1.11-4.57 vs CHD 8.87, 6.56-11.18, P = 0.038). There were no significant differences in the functional indices, but CI and CHD patients also showed a trend towards greater complexity than CHB. No differences were found for any HBV quasispecies complexity indices between CHD and CI patients. G-to-A and C-to-T nucleotide changes, characteristic of APOBEC3 G, were higher in CHD and CI than in CHB in genotype A haplotypes, but not in genotype D. The proportion of nt G-to-A vs A-to-G changes and C-to-T vs T-to-C changes in genotype A and D haplotypes in CHD patients showed no significant differences. In CHB and CI the results of these comparisons were dependent on HBV genotype.CONCLUSION The lower-replication CHD and CI groups show a trend to higher quasispecies complexity than the higher-replication CHB group. The mechanisms associated with this greater complexity require elucidation. | Cristina Godoy David Tabernero Sara Sopena Josep Gregori Maria Francesca Cortese Carolina González Rosario Casillas Mar?al Yll Ariadna Rando Rosa López-Martínez Josep Quer Gloria González-Aseguinolaza Rafael Esteban Mar Riveiro-Barciela Maria Buti Francisco Rodríguez-Frías | 2019 | World Journal of Gastroenterology2019，25，13： | 6 |
| 6 | Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy显示文摘AIM To detect hyper-conserved regions in the hepatitis B virus(HBV) X gene(HBX) 5' region that could be candidates for gene therapy.METHODS The study included 27 chronic hepatitis B treatmentnaive patients in various clinical stages(from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeA g-negative and HBeA g-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia > 3.5 log IU/m L, the HBX 5' end region [nucleotide(nt) 1255-1611] was PCRamplified and submitted to next-generation sequencing(NGS). We assessed genotype variants by phylogenetic analysis, and evaluated conservation of this region by calculating the information content of each nucleotide position in a multiple alignment of all unique sequences(haplotypes) obtained by NGS. Conservation at the HBx protein amino acid(aa) level was also analyzed.RESULTS NGS yielded 1333069 sequences from the 27 samples, with a median of 4578 sequences/sample(2487-9279, IQR 2817). In 14/27 patients(51.8%), phylogenetic analysis of viral nucleotide haplotypes showed a complex mixture of genotypic variants. Analysis of the information content in the haplotype multiple alignments detected 2 hyper-conserved nucleotide regions, one in the HBX upstream non-coding region(nt 1255-1286) and the other in the 5' end coding region(nt 1519-1603). This last region coded for a conserved amino acid region(aa 63-76) that partially overlaps a Kunitz-like domain.CONCLUSION Two hyper-conserved regions detected in the HBX 5' end may be of value for targeted gene therapy, regardless of the patients' clinical stage or HBV genotype. | Carolina González David Tabernero Maria Francesca Cortese Josep Gregori Rosario Casillas Mar Riveiro-Barciela Cristina Godoy Sara Sopena Ariadna Rando Marcal Yll Rosa Lopez-Martinez Josep Quer Rafael Esteban Maria Buti Francisco Rodríguez-Frías | 2018 | World Journal of Gastroenterology2018，24，19： | 6 |
| 7 | Systemic inflammatory response syndrome and primary of spontaneous intracerebral haemorrhage显示文摘 | Godoy D Boccio A Hugo N | 2002 | Rev Neurol2002，35，： | 4 |
| 8 | High Helicobacter pylori Resistance to Metronidazole and Clarithromycin in Brazilian Children and Adolescents显示文摘 | Silvio K. Ogata Anita P. Ortiz Godoy Francy R. da Silva Patricio Elisabete Kawakami | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，6： | 3 |
| 9 | Root associations in Austrocedrus forests and seasonal dynamics of arbuscular mycorrhizas显示文摘 | S. Fontenla R. Godoy P. Rosso M. Havrylenko | 1998 | Mycorrhiza1998，，： | 2 |
| 10 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 11 | Interfacially activated lipases against hydrophobic supports: Effect of the support nature on the biocatalytic properties显示文摘 | Gloria Fernandez-Lorente Zaida Cabrera Cesar Godoy Roberto Fernandez-Lafuente Jose M. Palomo Jose M. Guisan | 2008 | Process Biochemistry2008，，10： | 2 |
| 12 | Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage显示文摘 | Steven Dooley Jafar Hamzavi Loredana Ciuclan Patricio Godoy Iryna Ilkavets Sabrina Ehnert Elke Ueberham Rolf Gebhardt Stephan Kanzler Andreas Geier Katja Breitkopf Honglei Weng Peter R. Mertens | 2008 | Gastroenterology2008，，2： | 2 |
| 13 | 应用双源多层螺旋CT评估腹主动脉瘤血管内修补术后腹主动脉的初步研究显示文摘目的 评估在腹主动脉瘤(AAAs)血管内修补术后病人中应用双能多层螺旋CT减少放射剂量的可能性。材料和方法 本前瞻性研究遵从HIPAA并获得了机构委员会批准。对22例腹主动脉瘤血管内修补术后病人进行了24次双能多层螺旋CT检查,包括平扫、动脉期、静脉期。虚拟平扫采用静脉期纯80kV及平均峰值电压的加权CT数据。 | H. Chandarana M.C. Godoy I. Vlahos A. Graser J. Babb C. Leidecker 姜卫香 | 2009 | 国际医学放射学杂志2009，32，1： | 2 |
| 14 | A method for the economic valuation of non-timber tropical forest products 显示文摘 | Godoy R Lubowski R Markandya A | 1993 | Economic Botany1993，47，3： | 1 |
| 15 | B cells are involved in the modulation of pathogenic gut immune response in food - allergic entropathy显示文摘 | Cardoso CR Provinciatto PR Godoi DF | 2008 | Clin Exp Immunol2008，154，2： | 1 |
| 16 | Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer:ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues显示文摘 | Godoy A Ulloa V Rodríguez F | 2006 | J Cell Physiol2006，207，3： | 1 |
| 17 | PPAR expression is increased in systemic lupus erythematosus patients and represses CD40/ CD40L signaling pathway显示文摘 | Oxer DS Godoy LC Borba E | 2011 | Lupus2011，20，： | 1 |
| 18 | Effect of bleaching gels on the surface roughness, hardness, and micromorphology of composites 显示文摘 | Garcia-Godoy F Garcia Godoy A Gareia- Godoy F | 2002 | Gen Dent2002，50，3： | 1 |
| 19 | Comprehensive mass-spectrometry-based proteome quantification of haploid ver-sus diploid yeast显示文摘 | de Godoy L.M Olsen J.V Cox J Nielsen M.L. Hubner N.C. Frohlich F. Walther T.C. Mann M | | 0，，： | 1 |
| 20 | Growth patterns of pituitary adenomas and histopathological correlates显示文摘 | Monsalves E Larjani S Loyola Godoy B | 2014 | J Clin Endo- crinol Metab2014，99，： | 1 |
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