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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Myenteric neurons and intestinal mucosa of diabetic rats after ascorbic acid supplementation显示文摘AIM: To investigate the effect of ascorbic acid (AA) dietary supplementation on myenteric neurons and epithelial cell proliferation of the jejunum of adult rats with chronic diabetes mellitus. METHODS: Thirty rats at 90 d of age were divided into three groups: Non-diabetic, diabetic and diabetic treated with AA (DA) (1 g/L). After 120 d of treatment with AA the animals were killed. The myenteric neurons were stained for myosin-V and analyzed quantitatively in an area of 11.2 mm2/animal. We further measured the cellular area of 500 neurons per group. We also determined the metaphasic index (MI) of the jejunum mucosa layer of about 2500 cells in the intestinal crypts, as well as the dimensions of 30 villi and 30 crypts/animal. The data area was analyzed using the Olympus BX40 microscope. RESULTS: There was an increase of 14% in the neuronal density (792.6 ± 46.52 vs 680.6 ± 30.27) and 4.4% in the cellular area (303.4 ± 5.19 vs 291.1 ± 6.0) respectively of the diabetic group treated with AA when compared to control diabetic animals. There were no signifi cant differences in MI parameters, villi height or crypt depths among the groups.CONCLUSION: Supplementation with AA in the diabetic animal promoted moderate neuroprotection. There was no observation of alteration of the cellular proliferation of the jejunum mucosa layer of rats with chronic diabetes mellitus with or without supplementation with AA. | Priscila de Freitas Maria Raquel Maral Natali Renata Virginia Fernandes Pereira Marcilio Hubner Miranda Neto Jacqueline Nelisis Zanoni | 2008 | World Journal of Gastroenterology2008，14，42： | 3 |
| 3 | 磁性纳米结构中由激光引起的超快自旋动力学研究显示文摘以单个磁性中心的NiO以及由Co和Ni等元素构成的双磁性中心的纳米结构为例,总结了近年所做的主要工作.为了在理论上实现磁性纳米结构中的超快自旋翻转和转移,提出了一种称为Λ进程(Λprocess)的超快自旋转换机理.在实际计算中,首先采用量子化学第一性原理计算得到磁性纳米结构中精确的隙间d电子态,然后考虑外加磁场和自旋轨道耦合分析磁性原子中的自旋局域化程度,最后引入激光脉冲项,研究在其作用下材料的自旋态经由Λ进程实现转换的时间历程.研究结果表明自旋翻转和转移可以在线偏振光的作用下在亚皮秒的时间尺度内完成.为了进一步实现对磁性分子自旋操控的检测和监控,采用附加于磁性中心上的CO分子对磁性分子进行标记.计算得到的与自旋态相关的C—O键振动频率表明自旋操控可以较容易地经由红外光谱实验间接监控. | 李春 杨帆 Georgios Lefkidis Wolfgang Hubner | 2011 | 物理学报2011，60，1： | 2 |
| 4 | Single-Molecule Identification by Spectrally and Time-Resolved Fluorescence Detection 显示文摘 | Prummer M Hubner C G Sick B | 2000 | Anal Chem2000，72，3： | 2 |
| 5 | Ontology-based search for interactive digital maps显示文摘 | HUBNER S SPITrEL R VISSER U | 2004 | IEEE Intelligent Systems2004，119，3： | 1 |
| 6 | Self-concept: Validation of construct interpretations 显示文摘 | Shavelson RJ Hubner J J Slanton GC | 1976 | Review of Educational Research1976，46，： | 1 |
| 7 | Comprehensive mass-spectrometry-based proteome quantification of haploid ver-sus diploid yeast显示文摘 | de Godoy L.M Olsen J.V Cox J Nielsen M.L. Hubner N.C. Frohlich F. Walther T.C. Mann M | | 0，，： | 1 |
| 8 | A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity显示文摘 | Schneikert J Hubner S Martin E | 1999 | J Cell Biol1999，146，5： | 1 |
| 9 | A prospective study of personality characteristics,occupational stressors,and burnout among school psychology practitioners显示文摘 | MILLS L B HUBNER E S | 1998 | J Sch Psychol1998，36，1： | 1 |
| 10 | A Model for the Structural, Functional, and Deontic Specification of Organiza- tions in Muhiagent Systems显示文摘 | HUBNER J SICHMAN J BOISSIER O | 2002 | Advances in Artificial Intelli- gence2002，2507，2002： | 1 |
| 11 | ERCP is s',ffe and ef- fective in patients 80 years of age and older compared with youn- ger patients显示文摘 | Fritz E0 Kirchgatterer A Hubner D | 2006 | Gastrointest Endosc2006，64，6： | 1 |
| 12 | Load and Boundary Condition Calibration Using Full-field Strain Measurement显示文摘 | S. Padmanabhan J. P. Hubner A. V. Kumar P. G. Ifju | 2006 | Experimental Mechanics2006，，5： | 1 |
| 13 | Ontology-based Search for Interactive Digital Maps显示文摘 | Hubner S Spittel R Visse U | 2004 | IEEE Intelligent Systems2004，19，3： | 1 |
| 14 | Multicenter,prospective, randomized trial of 4 vs 6F French catheters in 410patients undergoing coronary angiography 显示文摘 | Hubner PT Hudson N | 2001 | Catheter Cardiovasc Interv2001，64，3： | 1 |
| 15 | Gadoliniumlabeled liposomes: targeted MR contrast agents for the liver and spleen显示文摘 | KABALKA G BUONOCORE E HUBNER K | 1987 | Radiology1987，163，1： | 1 |
| 16 | The impact of hyperhomocyseinemia as a cardiovascular risk factor in the prediction of coronary heatr diseade显示文摘 | Geisel J Hennen B Hubner U | 2003 | Cin Chem Lab Med2003，41，15： | 1 |
| 17 | Polymerase chain reaction in the quality and safety assurance of food:Detection of soya in processed meat products显示文摘 | Meyer R Chardonnens F Hubner P | 1996 | Z Lebensm Unters Forsch1996，203，： | 1 |
| 18 | Plant--Rhizosphere- Microflora Association during phytoremediation of PAH- contaminated soil显示文摘 | Muratova A Hubner T Tischer S | 2003 | Int J Phytoremediation2003，5，2： | 1 |
| 19 | The impact of hyperho- mocysteinemia as a cardiovascular risk factor in the prediction of coronary heart disease显示文摘 | Geisel J Hennen B Hubner U | 2003 | Clin Chem Lab Med2003，41，11： | 1 |
| 20 | Preliminary development and validation of a multidimensional life satisfaction scale for children显示文摘 | HUBNER E S | 1994 | Psychological Assessment1994，6，2： | 1 |
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