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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Application of highresolution thermal infrared remote sensing and GIS to assess the urban heat island effect 显示文摘 | Lo C P Quattrovhi D A and Luvall J C | 1997 | International Journal of Remote Sensing1997，18，2： | 2 |
| 3 | 14 MeV neutron yields from D-T operation of the MIT Cockcroft-Walton accelerator显示文摘 | Borras M C Lo D H Petrasso R D | 1993 | Journal of Fusion Energy1993，12，3： | 2 |
| 4 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 5 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 6 | Reclassification of aggressive adenomatous mastoid neoplasms as endolymphatic sac tumors显示文摘 | Li J C Brackmann D E Lo W W | 1993 | Laryngoscope1993，103，12： | 1 |
| 7 | A strain-based design method for the collapse limit state of reinforced soil walls or slopes显示文摘 | LO S C R Xu D W | 1992 | Can Geotech J1992，29，5： | 1 |
| 8 | The effect of setup uncertainties on the radiobiological advantage of fractionation in stereotaxic radiotherapy显示文摘 | Lo Y C Ling C C Larson D A | 1996 | In J Radiat Oncol Biol Plays1996，34，5： | 1 |
| 9 | Properties of SiO2-like barrier layers on polyethersulfone substrates by low-temperature plasma-enhanced chemical vapor deposition显示文摘 | Wuu D S Lo W C Chang L S | 2004 | Thin Solid Films2004，468，1： | 1 |
| 10 | Drinking and driving in Singapore,1987 to 1989显示文摘 | Chao T C Lo D S T Bloodworth B C | | 0，，03： | 1 |
| 11 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 12 | Evaluation of the effects of pulsed magnetic field treatment as a nondestructive treatment for magnetic materials显示文摘 | Lo CC H Jiles D C Mina M | 2002 | Materials Evaluation2002，60，8： | 1 |
| 13 | Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin显示文摘 | Musumeci G Lo Furno D Loreto C | | 0，，： | 1 |
| 14 | A hardware implementation of realloc function显示文摘 | Srisa-an W Lo C D Chang J M | 1999 | Integration the VLSI Journal1999，28，： | 1 |
| 15 | Chinese female nursing students'coping strategies,self-esteem and related factors in different years ofschool显示文摘 | Ni C P Lo D W Liu X W | 2012 | Journal of Nursing Education and Practice2012，2，4： | 1 |
| 16 | Effect of methylcholanthrene - induced sarcoma and its removal on rats plasma and intracellular free amino acid content 显示文摘 | Lo C- C Meguid MM Rivera D | 1987 | Surgical Research Communications1987，，1： | 1 |
| 17 | Mutations inGDI1 are responsible for X-linked non-specific mental retar-dation显示文摘 | D'Adamo P Menegon A Lo Nigro C | 1998 | Nat Genet1998，19，： | 1 |
| 18 | c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and-independent mechanisms显示文摘 | LO D GLIMCHER L H | 1998 | J Exp Med1998，188，： | 1 |
| 19 | Application of high-resolution thermal infrared remote sensing and GIS to assess the urban heat island effect显示文摘 | LO C P QUA3TROCHI D A LUVALL J C | 1997 | International Journal of Remote Sensing1997，18，2： | 1 |
| 20 | eDNA cloning of a sor- ghum pathogenesis-related protein(PR-10) and differential expres- sion of defense-related genes following inoculation with Cochliobo- lus heterostrophus or CoUetotrichum sublineolum 显示文摘 | Lo S C C Hipskind J D Nieholson R L | 1999 | Molecular Plant Microbe Intelactions1999，12，： | 1 |
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