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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 3 | The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a pilot study显示文摘 | Janssens GO Gidding CE Van Lindert E J Oldenburger FR Erasmus CE Schouten-Meeteren A Y Kaanders JH | 2009 | 中国神经肿瘤杂志2009，7，3： | 8 |
| 4 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 5 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 6 | Requirments for neutrophil products and L-arginine in ischemia-reperfusion injury显示文摘 | Seekamp A Mulligan MS Till GO | 1993 | Am J Pathol1993，142，4： | 1 |
| 7 | Guidelines for treatment of autoimmune neuromuscular transmission disorders显示文摘 | Skeie GO Apostolski S Evoli A | | 0，，： | 1 |
| 8 | Structure and thermal properties of blends of nylon 6 and a liquid crystal copolyester显示文摘 | Campoy I Go'mez M A Marco C | | 0，，25： | 1 |
| 9 | Guidelines for treatment of autoimmune neuromuscular transmission disorders 显示文摘 | Skeie GO Apost01ski S Evoli A | 2010 | Eur J Neurol2010，17，7： | 1 |
| 10 | Thirty-day mortality after ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation on and off anticoagulants显示文摘 | Fang M C Go A S Chang Y | 2012 | Stroke2012，43，7： | 1 |
| 11 | Study of spectral analytical data using fin- gerprints and scaledsimilarity measurements显示文摘 | M Urbano Cuadrado M D Luque de Castro M A Go mez-Nieto | 2005 | Anal Bioanal Chem2005，381，： | 1 |
| 12 | Thera-peutic efficacy and effects of artemether-lumefantrine andartesunate-amodiaquine coformulated or copackaged on ma-laria-associated Anemia in children with uncomplicatedplasmodium falciparum malaria in southwest nigeria显示文摘 | Gbotosho GO Sowunmi A Okuboyejo TM | 2011 | Am J Trop Med Hyg2011，84，： | 1 |
| 13 | Excimer laser in situ keratomileusis under a corneal flap for myopia of 2 to 20 diopters显示文摘 | Salah T Waring Ⅲ Go Maghraby A | 1996 | Am J Ophthalmol1996，121，2： | 1 |
| 14 | Hypovitaminosis D is associated with insulin resistance and β cell dysfunction显示文摘 | Chiu KC Chu A Go VL | 2004 | Am J Clin Nutr2004，79，： | 1 |
| 15 | Chronic kidney dis- ease and the risks of death, cardiovascular events, and hospi- talization显示文摘 | GO A S CHERTOW G M FAN D | 2004 | N Engl J Med2004，351，13： | 1 |
| 16 | Clinical, EEG, MRI, MEG, and surgical outcomes of pediatric epilepsy with astrocytic inclu- sions versus focal cortical dysplasia 显示文摘 | Alshafai L Ochi A Go C | 2014 | Epilepsia2014，55，10： | 1 |
| 17 | Jeavons syndrome existing as occipital cortex initiating generalized epilepsy 显示文摘 | Viravan S Go C Ochi A | 2011 | Epilep-sia2011，52，7： | 1 |
| 18 | Automated in situ keratomileusis for myopia 显示文摘 | Ibrahim O Waring GO Salah T el Maghraby A | 1995 | J Refract Surg1995，11，6： | 1 |
| 19 | Allelopathy and microclimatic modification of intercropping with marigold on tomato early blight disease development 显示文摘 | GO' MEZ R O ZAVALETA M E GONZA' LEZ H A | 2003 | Field Crops Research2003，83，： | 1 |
| 20 | Single uucleotide polym orphisms in the proximal promoter region of the adiponectin gene are associated with type 2diabetes in Swedish Caucasians显示文摘 | Harvest FG Adili A Claes GO | 2004 | Diabetes2004，53，： | 1 |
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