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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 3 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 4 | Cancer chemopreventive activity of resveratrol,a natural product derived from grapes显示文摘 | Jang M Cai L Udeani GO | 1997 | Science1997，275，： | 2 |
| 5 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 6 | ln situ gene expression and localization of metalloproteinases MMPI,MMP2,MMP3,MMP9,and theirinhibitors TIMP1 and TIMP2 in human renal cell carcinoma显示文摘 | Bhuvarahamurthy V Kristiansen GO Johannsen M | 2006 | Oncol Rep2006，15，5： | 1 |
| 7 | Beta2-adrenergic receptor polymorphysim at condon 16,cardiovascular phenotypesand essential hypertension in whites and African Americans显示文摘 | HERRMANN V BUSCHER R GO M M | 2000 | Am J Hypertens2000，13，： | 1 |
| 8 | Neurotropin induces antinociceptive effect by enhancing descending pain inhibitory sys- tems involving 5 - HT3 and noradrenergic alpha - receptors in spi- nal dorsal hom显示文摘 | Kawamura M Ohara H Go K | 1998 | Life Sci1998，62，21： | 1 |
| 9 | Insulin- leptin - visceral fat relation during weight loss显示文摘 | Yip I Go V L Hershman J M | 2001 | Pancreas2001，23，： | 1 |
| 10 | Critical evaluation of bcl-6 protein expression in diffuse large B-cell lymphoma of the stomach and small intestine显示文摘 | Kwon M S Go J H Choi J S | 2003 | Am J Surg Pathol2003，27，： | 1 |
| 11 | Cancer chemopreventive ac- tivity of resveratrol, a natural product derived from grapes 显示文摘 | Jang M Cai L Udeani GO | 1997 | Science1997，275，5297： | 1 |
| 12 | Nutri?ent-gene interaction: metabolic genotype-phenotype re?lationship显示文摘 | GO V L NGUYEN C T HARRIS D M | 2005 | TheJournal of Nutrition2005，135，12： | 1 |
| 13 | Ecologicallimits to plant phenotypic plasticity 显示文摘 | Valladares F Gianoli E Go mez J M | 2007 | NewPhytologist2007，176，4： | 1 |
| 14 | Wound healing after excimer laser keratomileusis ( photorefractive keratectomy ) in monkeys 显示文摘 | Fantes FE Hanna KD Waring GO Pouliquen Y Thompson KP Savoldelli M | 1990 | Arch Ophthal- mol1990，108，5： | 1 |
| 15 | Projected destination image online: Websitecontent analysis of pictures and text显示文摘 | Govers R Go F M | 2005 | Information Technology& Tourism2005，7，2： | 1 |
| 16 | Structure and thermal properties of blends of nylon 6 and a liquid crystal copolyester显示文摘 | Campoy I Go'mez M A Marco C | | 0，，25： | 1 |
| 17 | Cancer chemopreventive activity of resveratrol, a natural product derived from grapes显示文摘 | Jang M Cai L Udeani GO | 1997 | Science1997，275，5297： | 1 |
| 18 | Thirty-day mortality after ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation on and off anticoagulants显示文摘 | Fang M C Go A S Chang Y | 2012 | Stroke2012，43，7： | 1 |
| 19 | Probiotie treatment increases salivary counts of lactobaeilli: a double-blind, randomized, controlled study显示文摘 | MONTALTO M VASTOLA M MAR/GO L | 2004 | Digestion2004，69，1： | 1 |
| 20 | Novel approaches in anti-angiogenic treat- ment targeting endothelial F-aetin: a new anti-angiogenic strategy?显示文摘 | Thoenes L GO nther M | 2008 | Curr Opin Mol Ther2008，10，6： | 1 |
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