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| 1 | A Review on Pharmacological and Analytical Aspects of Naringenin显示文摘Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits(grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders. | Kanika Patel Gireesh Kumar Singh Dinesh Kumar Patel | 2018 | Chinese Journal of Integrative Medicine2018，24，7： | 28 |
| 2 | Hepatoprotective effect of Solatium xanthocarpum fruit extract against CCl_4 induced acute liver toxicity in experimental animals显示文摘Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. | Ramesh K Gupta Talib Hussain G.Panigrahi Avik Das Gireesh Narayan Singh K Sweety Md Faiyazuddin Chandana Venkateswara Rao | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 4 |
| 3 | Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture显示文摘 | G. Gireesh Santhosh K. Thomas Binoy Joseph C.S. Paulose | 2009 | Journal of Ethnopharmacology2009，，3： | 3 |
| 4 | Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni显示文摘Campylobacter jejuni(C. jejuni),a Gram-negative microaerophilic bacterium,is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen,our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate(poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally,the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria,which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans. | Anand Kumar Dharanesh Gangaiah Jordi B Torrelles Gireesh Rajashekara | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 5 | Acute and sub-chronic toxicity study of standardized extract of Fumaria indica in rodents显示文摘 | Gireesh Kumar Singh Vikas Kumar | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 6 | Phospholipase C beta 4 in tile medi- al septum controls cholinergie theta oscillations and anxiety behaviors 显示文摘 | Shin J Gireesh G Kim SW | 2009 | J Neurosei2009，29，15： | 1 |
| 7 | Activation of aluminium alloy sacrificial anodes by selenium显示文摘 | Shibli S M A Gireesh V S | 2005 | Corrosion Science2005，，47： | 1 |
| 8 | Surface activation of aluminium alloy sacrificial anodes by IrO2 显示文摘 | Shibli S M A Gireesh V S | 2003 | Applied Surface Science2003，，219： | 1 |
| 9 | Surface catalysis based on ruthenium dioxide for effective activation of aluminium sacrificial anodes显示文摘 | Shibli S M A Gireesh V S Sony George | 2004 | Corrosion Science2004，，46： | 1 |
| 10 | Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors显示文摘 | Shin J Gireesh G Kim SW | 2009 | J Neurosci2009，29，15： | 1 |
| 11 | Biosynthesis of the antibiotic Nisin: Genomic organization and membrane localization of the NisB protein显示文摘 | Gireesh T | 1998 | Appl Environ Microbiol1998，58，11： | 1 |
| 12 | +TIP EB1 downregulates paclitaxel?induced proliferation inhibition andapoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules显示文摘 | Geethu Thomas Jamuna Sreeja K. Gireesh Hindol Gupta Tapas Manna | 2015 | International Journal of Oncology2015，，： | 1 |
| 13 | Surface catalysis based on ruthenium dioxide for effective activation of aluminium sacrificial anodes显示文摘 | S.M.A Shibli V.S Gireesh Sony George | 2004 | Corrosion Science2004，，4： | 1 |
| 14 | Quantitative analysis of grain refinement in titanium during equal channel angular pressing 显示文摘 | CHEN Y J LI Y J WALMSLEY J C DUMOULIN S GIREESH S S ARMADA S SKARET P C ROVEN H J | 2011 | Scripta Mater2011，64，： | 1 |
| 15 | Phospholipase and anxiety beh-aviors显示文摘 | Shin J Gireesh G Kim SW | 2009 | JNeurosci2009，29，15： | 1 |
| 16 | Quantitative study of grain refinement in AI-Mg alloy processed by equal channel angular pressing at cryogenic temperature 显示文摘 | CHEN Y J ROVEN H J GIREESH S S SKARET P C HJELEN J | 2011 | Materials Letters2011，65，： | 1 |
| 17 | Lactobacilli and Bifidobacteria enhance mucosal B cell responses and differentially modulate systemic antibody responses to an oral human rotavirus vaccine in a neonatal gnotobiotic pig disease model显示文摘 | Sukumar Kandasamy Kuldeep S Chattha Anastasia N Vlasova Gireesh Rajashekara Linda J Saif | 2014 | Gut Microbes2014，，5： | 1 |
| 18 | Optimization of EBSD parameters for ultra-fast characterization 显示文摘 | CHEN Y J HJELEN J GIREESH S S ROVEN H J | 2012 | Journal of Microscopy2012，245，： | 1 |
| 19 | ACM Transaction on Information Systems(1989-2006):A Bibliometric Study显示文摘 | Keshaval Gireesh A G Gowda M P | 2008 | Information Studies2008，14，4： | 1 |
| 20 | Microstructure and mechancical properties of Al-xMg alloys processed by room temperature ECAP 显示文摘 | CHEN Y J CHAI Y C ROVEN H J GIREESH S S YU Y D HJELEN J | 2012 | Mater Sci Eng A2012，545，： | 1 |
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