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| 1 | Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease显示文摘Reactive oxygen species(ROS) are produced during normal physiologic processes with the consumption of oxygen. While ROS play signaling roles, when they are produced in excess beyond normal antioxidative capacity this can cause pathogenic damage to cells. The majority of such oxidation occurs in polyunsaturated fatty acids and sulfhydryl group in proteins, resulting in lipid peroxidation and protein misfolding, respectively. The accumulation of misfolded proteins in the endoplasmic reticulum(ER) is enhanced under conditions of oxidative stress and results in ER stress, which, together, leads to the malfunction of cellular homeostasis. Multiple types of defensive machinery are activated in unfolded protein response under ER stress to resolve this unfavorable situation. ER stress triggers the malfunction of protein secretion and is associated with a variety of pathogenic conditions including defective insulin secretion from pancreatic β-cells and accelerated lipid droplet formation in hepatocytes. Herein we use nonalcoholic fatty liver disease(NAFLD) as an illustration of such pathological liver conditions that result from ER stress in association with oxidative stress. Protecting the ER by eliminating excessive ROS viathe administration of antioxidants or by enhancing lipidmetabolizing capacity via the activation of peroxisome proliferator-activated receptors represent promising therapeutics for NAFLD. | Junichi Fujii Takujiro Homma Sho Kobayashi Han Geuk Seo | 2018 | World Journal of Biological Chemistry2018，9，1： | 17 |
| 2 | Pathological bacterial translocation in liver cirrhosis显示文摘 | Reiner Wiest Melissa Lawson Markus Geuking | 2014 | Journal of Hepatology2014，，1： | 8 |
| 3 | Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers显示文摘 | Rieko Hamaoka Yuji Yaginuma Tomoaki Takahashi Junichi Fujii Masahiko Koizumi Han Geuk Seo Yutaka Hatanaka Kaoru Hashizume Kunio Ii Jun-ichiro Miyagawa Toshiaki Hanafusa Yuji Matsuzawa Mutsuo Ishikawa Naoyuki Taniguchi | 1999 | Journal of Cancer Research and Clinical Oncology1999，，6： | 1 |
| 4 | Nitric oxide up-regulates aldose reductase expression in rat vascular smooth muscle cells:A potential role for aldose reduetase in vascular remodeling显示文摘 | Tom Nishinaka Chihiro Yabe-Nishimura | 2000 | Molecular Pharmacology2000，57，4： | 1 |
| 5 | The habitat, double life, citizenship, and forgetfulness of IgA 显示文摘 | Maepherson A J Geuking MB Slack E | 2012 | Immunol Rev2012，245，1： | 1 |
| 6 | Structure design and test of enterprise security management system with advanced internal security 显示文摘 | Seoksoo Kima Geuk Lee | 2009 | Future generation computer systems2009，25，3： | 1 |
| 7 | Intestinal bacterial colonization induces mutualistic regulatory T cell responses显示文摘 | Geuking MB Cahenzli J Lawson MA | 2011 | Immunity2011，34，5： | 1 |
| 8 | Intestinal bacterial colonization induces mutualistic regulatory T cell responses显示文摘 | Geuking MB Cahenzli J Lawson MA | 2011 | Immunity2011，34，5： | 1 |
| 9 | The interplay between the gut microbiota and the immune system显示文摘 | Geuking MB Koller Y Rupp S | 2014 | Gut Microbes2014，5，41： | 1 |
| 10 | Expression of nitric oxide synthase in macula densa in streptozotocin diabetic rats显示文摘 | N. Yagihashi N. Nishida H. Geuk Seo N. Taniguchi S. Yagihashi | 1996 | Diabetologia1996，，7： | 1 |
| 11 | Pathological bacterial translocationin liver cirrhosis显示文摘 | Wiest R M Lawson M Geuking | 2013 | J Hepatol2013，，： | 1 |
| 12 | Pathological bacterial translocation in liver cirrhosis显示文摘 | Wiest R Lawson M Geuking M | 2014 | J Hepatol2014，60，： | 1 |
| 13 | Activation of self-focus and self-presentation traits under private, mixed, and public pressure显示文摘 | Geukes K Mesagno C Hanrahan S J | 2013 | Journal of sport & eacercise psy- chology2013，35，1： | 1 |
| 14 | Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kB activation显示文摘 | Jong Woo Kim Yong Chun Jin Young Min Kim Sangho Rhie Hye Jung Kim Han Geuk Seo Jae Heun Lee Yeong Lae Ha Ki Churl Chang | 2008 | Life Sciences2008，，7： | 1 |
| 15 | Testing an inter- actionist perspective on the relationship between personality traits and performance under public pressure显示文摘 | Geukes K Mesagno C Hanrahan S J etal | 2012 | Psychology of Sport and E:rercise2012，13，3： | 1 |
| 16 | Performing under pressure in private: Activation of self-focus traits 显示文摘 | Geukes K Mesagno C Hanrahan S J | 2013 | International Journal of Sport and Exercise Psy- chology2013，11，1： | 1 |
| 17 | Intestinal bacterial colonization induces mutualistic regulatory T cell responses 显示文摘 | Geuking MB Cahenzli J Lawson MA | 2011 | Immunity2011，34，5： | 1 |
| 18 | Intestinal bacterial colonization induces mutualistic regulatory T cell responses显示文摘 | Geuking MB Cahenzli J Lawson MA | 2011 | Immunity2011，34，5： | 1 |
| 19 | A non-redundantrole for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediatedactivation ofJNK显示文摘 | Geuking P Narasirmmurthy R Lemaltre B | 2009 | PLoS One2009，4，11： | 1 |
| 20 | Genomic correlates of response to CTLA-4 blockade in metastatic melanoma显示文摘 | Van Allen Eliezer M. Miao Diana Schilling Bastian Shukla Sachet A. Blank Christian Zimmer Lisa Sucker Antje Hillen Uwe Geukes Foppen Marnix H. Goldinger Simone M. Utikal Jochen Hassel Jessica C. Weide Benjamin Kaehler Katharina C. Loquai Carmen Mohr Peter | 2015 | Science . 2015 (6257)2015，，6257： | 1 |
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