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71篇 您的检索式：作者名="Sucker"

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	题名	作者	年代	出处	被引量
1	Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy.	Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel	2019	Cell Research2019，29，10：	6
2	慢性淋巴细胞白血病伴多发性骨髓瘤:共同克隆起源的证明(英文)显示文摘研究一例慢性B淋巴细胞白血病(CLL)伴多发性骨髓瘤(MM)的患者。用FACS预先分离CLL和MM的细胞。免疫球蛋白的重链基因的免疫球蛋白的决定互补区Ⅲ(CDRⅢ)DNA序列分析显示在CLL和MM细胞群有相同的基因重排。本研究证明CLL和MM均有共同的克隆起源。	Christoph Sucker Alwin Kramer Marion Moos Hartmut Goldsehmidt	2004	The Chinese-German Journal of Clinical Oncology2004，3，2：	2
3	Angiopoietin-2 levels are as- sociated with disease progression in metastatic malignant melanoma 显示文摘	Helfrich I Edler L Sucker A	2009	Clin Cancer Res2009，15，4：	1
4	Hepatitis C virus (HCV) genotype distribution in German isolates: studies on the sequence variability in the E2 and NS5 region显示文摘	G. Driesel D. Wirth K. Stark R. Baumgarten U. Sucker E. Schreier	1994	Archives of Virology (-)1994，，3：	1
5	Citrate Plasma Levels in Patients Under Regional Anticoagulation in Continuous Venovenous Hemofihration显示文摘	Hetzel G R Taskaya G Sucker C	2006	American Journal of Kidney Diseases2006，48，5：	1
6	Are prothrombotic va- riants of platelet giycoprotein receptor polymorphisms in- volved in the pathogenesis of thrombotic microangiopathies 显示文摘	Sucker C Schmitz M Hetzel G R	2009	Clin Appl Thromb Hemost2009，15，4：	1
7	Neues Beheizungssystem mit Rohrregenerator und Flachflammenbrenner 显示文摘	Adler W Bender W Sucker D	2005	VDIBeriehte 18882005，，：	1
8	Fatal bleeding due to a hep- arin-like anticoagulant in a 37-year-old woman suffering from sys- temic mastocytosis 显示文摘	Sucker C Mansmann G Steiner S	2008	Clin Appl Thromb Hemost2008，14，：	1
9	Bubble bed reactor:areactoe design to minimize t he damage of bubble aeration on animal cells显示文摘	SUCKER H G JORDAN M EPPENBERGER H M	1994	Biotechnol and Bioeng1994，44，12：	1
10	Are prothrombotic variants of platelet glycoprotein receptor polymorphisms involved in the pathogenesis of thrombotic microangiopathies?显示文摘	Sucker C Schmitz M Hetzel GR	2009	Clin Appl Thromb Hemost2009，15，4：	1
11	Citrate plasma levels in patients un- der regional anticoagulation in continuous venovenous hemofiltration显示文摘	Hetzel GR Taskaya G Sucker C	2006	AM J Kidney Dis2006，48，：	1
12	Differential clinical signifi- cance of individual NKG2D ligands in melanoma:soluble ULBP2 as an indicator of poor prognosis superior to S100B显示文摘	Paschen A Sucker A Hill B	2009	Clin Cancer Res2009，15，16：	1
13	Nd salt of 3-salfoisonicotimic acid as an antithrombotic显示文摘	Vincke E Sucker E	1950	Klin Wschr1950，28，：	1
14	Are prothrombotic variants of platelet glycoprotein receptor polymorphisms involved in the pathogenesis of thrombotic microangiopathies?显示文摘	Sucker C Schmitz M Hetzel GR	2009	Clin Appl Thromb Hemost2009，15，4：	1
15	Tumor type M2 pyruvate kinase ( TU M2 - PK) as a novel plasma tumor marker in melanoma显示文摘	Ugurel S Bell N Sucker A	2005	Int J Cancer2005，117，5：	1
16	Biologically aclive secondary rnetabolites of endophytic Pezicula species显示文摘	SchuIz B Sucker J Aust H J	1995	MycolRes1995，99，10：	1
17	Adult Langerhans cell histiocytosis 显示文摘	Stockschlaeder M Sucker C	2006	Eur J Haematol2006，76，5：	1
18	Cyclosporin formulation of dosage forms 显示文摘	Cavanak T Sucker H	1986	Prog Allergy1986，38，1：	1
19	Tumor type M2 pyru-vate kinase(TuM2-PK)as a novel plasma tumor markerin melanoma显示文摘	Ugurel S Bell N Sucker A	2005	Int J Cancer2005，117，：	1
20	Angiopoietin-2 lcvels are as- sociated with disease progression in metastatie malignant melanoma 显示文摘	Helfrich I Edler L Sucker A	2009	Clin Cancer Res2009，15，4：	1

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