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| 1 | NOD-like receptors mediated activation of eosinophils interacting with bronchial epithelial cells: a link between innate immunity and allergic asthma显示文摘对细菌的感染的天生的免疫的关键 intracytosolic 模式识别受体是象受体(NLR ) 一样的核苷酸绑定 oligomerization 领域(点头) 。我们阐明了 NOD1 和人的嗜曙红血球的调停 NOD2 的激活,为过敏发炎的主要受动器房间,在在过敏气喘与人的支气管的上皮的 BEAS-2B 房间交往之上。嗜曙红血球组成地表示了 NOD1,2,但是展出了不重要的回答由 NOD1 ligand γ 在刺激之上释放 chemokines; -D-glutamyl-meso-diaminopimelic 酸(即弹跳) 和 NOD2 ligand muramyl dipeptide (MDP ) 。然而,即弹跳和 MDP 能显著地 CD18 的 upregulate 房间表面表示和细胞间的粘附分子(ICAM ) 嗜曙红血球上的 -1 和 BEAS-2B 房间上的 ICAM-1,以及在 coculture 系统导致 chemokines CCL2 和 CXCL8 版本(所有 P < 0.05 ) 。嗜曙红血球和 BEAS-2B 房间在在即弹跳或 MDP 刺激之上的 coculture 系统是为 CXCL8 和 CCL2 版本的主要来源。在嗜曙红血球和 BEAS-2B 房间之间的直接相互作用为 CCL2 版本负责,并且可溶的调停人在 CXCL8 版本被含有。英皇家空军之阶级最低之兵和 NF-κ B 玩为在 coculture 的粘附分子和 chemokines 的表示的规章的角色。有 NOD1,2 ligand 的处理能导致 subepithelial 纤维变性并且显著地提高全部的 IgE,为嗜曙红血球的 chemokine CCL5 和 T 助手类型的浆液集中 2 (Th2 )在 敏化ovalbumin 的过敏气喘的老鼠的 bronchoalveolar lavage 液体的房间和气喘 Th2 cytokine IL-13 (所有 P < 0.05 )。这研究在经由在煽动性的航线与支气管的上皮的房间交往的嗜曙红血球的激活触发过敏气喘提供 NOD1,2 的细菌的调停感染的激活的进一步的证据。 | Churl Kwok Wong Shuiqing Hu Karen Ming-Lam Leungt Jie Dong Lan He Yi Jun Chu Ida Miu-Ting Chu Huai-Na Qiu Kelly Yan-Ping Liu ChristopherWai-Kei Lam | 2013 | Cellular & Molecular Immunology2013，10，4： | 7 |
| 2 | An Improved Barcoded Oligonucleotide Primers-based Next-generation Sequencing Approach for Direct Identification of Viral Pathogens in Clinical Specimens显示文摘Objective To provide a feasible and cost-effective next-generation sequencing(NGS) method for accurate identification of viral pathogens in clinical specimens, because enormous limitations impede the clinical use of common NGS, such as high cost, complicated procedures, tremendous data analysis, and high background noise in clinical samples. Methods Viruses from cell culture materials or clinical specimens were identified following an improved NGS procedure: reduction of background noise by sample preprocessing, viral enrichment by barcoded oligonucleotide(random hexamer or non-ribosomal hexanucleotide) primer-based amplification, fragmentation-free library construction and sequencing of one-tube mixtures, as well as rapid data analysis using an in-house pipeline. Results NGS data demonstrated that both barcoded primer sets were useful to simultaneously capture multiple viral pathogens in cell culture materials or clinical specimens and verified that hexanucleotide primers captured as many viral sequences as hexamers did. Moreover, direct testing of clinical specimens using this improved hexanucleotide primer-based NGS approach provided further detailed genotypes of enteroviruses causing hand, foot, and mouth disease(HFMD) and identified other potential viruses or differentiated misdiagnosis events. Conclusion The improved barcoded oligonucleotide primer-based NGS approach is simplified, time saving, cost effective, and appropriate for direct identification of viral pathogens in clinical practice. | WANG Churl Hua NIE Kai ZHANG Yi WANG Ji ZHOU Shuai Feng LI Xin Na ZHOU Hang Yu QI Shun Xiang MA Xue Jun | 2017 | Biomedical and Environmental Sciences2017，30，1： | 7 |
| 3 | Experimental correlation of falling film absorption heat transfer on micro-scale hatched tubes显示文摘 | Chan Woo Park Sung Soo Kim Hyun Churl Cho | | 0，，03： | 1 |
| 4 | Complications of epilepsy surgery—A systematic review of focal surgical resections and invasive EEG monitoring显示文摘 | Walter J. Hader Jose Tellez‐Zenteno Amy Metcalfe Lisbeth Hernandez‐Ronquillo Samuel Wiebe Churl‐Su Kwon Nathalie Jette | 2013 | Epilepsia2013，，5： | 1 |
| 5 | Preparation of LiCoO2 from spent lithium-ion batteries 显示文摘 | Lee Churl Kyoung Rhee Kang-In | 2002 | Journal of Power Sources2002，109，： | 1 |
| 6 | Preparation of LiCoO2 from spent lithium-ion batteries显示文摘 | CHURL K L RHEE K I | 2002 | Power Sources2002，109，： | 1 |
| 7 | Preparation of LiCoO2 from spent lithium ion batteries显示文摘 | CHURL K L KANG I R | 2002 | Journal of Power Sources2002，109，1： | 1 |
| 8 | Composi- tions and sorptive properties of crop residue-derived chars 显示文摘 | Churl Yuan Sheng Guangyao Cary T Chiou | 2004 | Environ Sci Technol2004，38，17： | 1 |
| 9 | Inhibitory actions of mibefradil on steroidogenesis in mouse Leydig cells: involvement of Ca^2+ entry via the T-type Ca^2+ channel显示文摘细胞内部的营地和 Ca2+ 在 Leydig 房间涉及 steroidogenic 活动的规定,它协调回答到 luteinizing 荷尔蒙(LH ) 和人的 chorionic gonadotropin (hCG ) 。然而, Ca2+ 入口的鉴定在 Leydig 房间 steroidogenesis 含有不是明确的。这研究的目的是识别影响 Leydig 房间 steroidogenesis 的 Ca2+ 隧道的类型。在在刚分裂的 Leydig 的 vitro steroidogenesis,老鼠的房间被 hCG 孵化导致。steroidogenesis 上的 mibefradil (通常认为的 T 类型 Ca2+ 隧道 blocker ) 的效果用反向的抄写(RT ) 被估计为 steroidogenic 的聚合酶链反应分析用放射性免疫测定的尖锐规章的蛋白质(星) mRNA 表示和睾丸激素生产。面对 1.0 mmol L ? 1 细胞外的 Ca2+ ,在 1 ~ 100 IU 的 hCG 显著地提高了两星 mRNA 水平和睾丸激素分泌物(P < 0.05 ) ,并且 hCG 的 stimulatory 效果被 mibefradil 显著地以一种剂量依赖者方式减少(P < 0.05 ) 。而且,当外部 Ca2+ 被省略时,睾丸激素生产的导致 hCG 的增加完全被移开,暗示那个 Ca2+ 条目为导致 hCG 的 steroidogenesis 被需要。而且,补丁夹钳研究揭示了在一个集中范围看见的 mibefradil 敏感的 Ca2+ 水流的存在将近 paralleled 那些禁止的 steroidogenesis。一起,我们的数据提供刺激 hCG 的 steroidogenesis 被在鼠标的 Leydig 房间由 T 类型 Ca2+ 隧道执行的 Ca2+ 入口部分地至少调停的证据。 | Jae-Ho Lee Jong-Uk Kim Changhoon Kim Churl K. Min | 2010 | Asian Journal of Andrology2010，12，6： | 1 |
| 10 | Reductive Leaching of Cathodic Active Materials From Lithium Ion Battery Wastes显示文摘 | Churl Kyoung Lee Kang-In Rhee | 2003 | Hydrometallurgy2003，68，1： | 1 |
| 11 | Improvementin thermal stability of NaA zeolite composite membrane by control of intermediate layer structure 显示文摘 | Cho Churl Hee Oh Ka Yeon Kim Si Kyung | 2011 | Journal of Membrane Science2011，366，： | 1 |
| 12 | D : a-friedo-24-noroleanane triterpenoids from Tripterygium wilfordii 显示文摘 | Morota T Churl X Yang W | 1995 | Phytochemistry1995，39，5： | 1 |
| 13 | CuI4A is required for hematopoiet- ic cell viability and its deficiency leads to apoptosis 显示文摘 | Churl KT Waning DL Li B | 2008 | Blood2008，112，： | 1 |
| 14 | Preparation of Li- CoO2 from spent lithium - ion batteries 显示文摘 | Lee Churl Kyoung Rhee Kang - In | 2002 | Journal of Power Sources2002，109，： | 1 |
| 15 | Bipolar transistor with quantum well base 显示文摘 | S Mil' SHTEIN CHURl A PALAM J | 2008 | Microelectronics J2008，39，： | 1 |
| 16 | Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice显示文摘 | Eun Jung Park Young Min Kim Sang Won Park Hye Jung Kim Jae Heun Lee Dong-Ung Lee Ki Churl Chang | 2013 | Food and Chemical Toxicology2013，，： | 1 |
| 17 | Preparation of LiCoO2 from spent llthium-ion batteries显示文摘 | Churl K L Kang-In R | 2002 | J Power Sources2002，109，1： | 1 |
| 18 | Shape Optimization of Electromagnetic Devices Using Immune Algorithm 显示文摘 | Churl J S Kim M K Jung H K | 1997 | IEEE Trans on Magnetics (S0018-9464)1997，33，2： | 1 |
| 19 | Localization of Nogo-A and Nogo-66 Receptor Proteins at Sites of Axon-Myelin and Synaptie Contact 显示文摘 | Wang XX Churl SJ Treloar H | 2002 | Neurosei2002，22，13： | 1 |
| 20 | Synthesis of an iberiotoxin derivative by chemical ligation: A method for improved yields of cy- steine-rich scorpion toxin peptides显示文摘 | Bingham JP Churl JB Ruzicka MR | 2009 | Peptides2009，30，6： | 1 |
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