|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Origin and molecular characterization of the human-infecting H6N1 infl uenza virus in Taiwan显示文摘In June 2013,the fi rst human H6N1 infl uenza virus infec-tion was confirmed in Taiwan.However,the origin and molecular characterization of this virus,A/Taiwan/2/2013(H6N1),have not been well studied thus far.In the present report,we performed phylogenetic and coalescent analy-ses of this virus and compared its molecular profi le/char-acteristics with other closely related strains.Molecular characterization of H6N1 revealed that it is a typical avian infl uenza virus of low pathogenicity,which might not rep-licate and propagate well in the upper airway in mammals.Phylogenetic analysis revealed that the virus clusters with A/chicken/Taiwan/A2837/2013(H6N1)in seven genes,except PB1.For the PB1 gene,A/Taiwan/2/2013 was clus-tered with a different H6N1 lineage from A/chicken/Taiwan/A2837/2013.Although a previous study demonstrated that the PB2,PA,and M genes of A/Taiwan/2/2013 might be derived from the H5N2 viruses,coalescent analyses revealed that these H5N2 viruses were derived from more recent strains than that of the ancestor of A/Taiwan/2/2013.Therefore,we propose that A/Taiwan/2/2013 is a reassor-tant from different H6N1 lineages circulating in chickens in Taiwan.Furthermore,compared to avian isolates,a sin-gle P186L(H3 numbering)substitution in the hemaggluti-nin H6 of the human isolate might increase the mammali-an receptor binding and,hence,this strain’s pathogenicity in humans.Overall,human infection with this virus seems an accidental event and is unlikely to cause an infl uenza pandemic.However,its co-circulation and potential reas-sortment with other infl uenza subtypes are still worthy of attention. | Weifeng Shi Yi Shi Ying Wu Di Liu George F.Gao | 2013 | Protein & Cell2013，4，11： | 26 |
| 2 | Modeling,Control,and Protection of Modular Multilevel Converter-based Multi-terminal HVDC Systems:A Review显示文摘Multi-terminal direct current(MTDC)grids provide the possibility of meshed interconnections between regional power systems and various renewable energy resources to boost supply reliability and economy.The modular multilevel converter(MMC)has become the basic building block for MTDC and DC grids due to its salient features,i.e.,modularity and scalability.Therefore,the MMC-based MTDC systems should be pervasively embedded into the present power system to improve system performance.However,several technical challenges hamper their practical applications and deployment,including modeling,control,and protection of the MMC-MTDC grids.This paper presents a comprehensive investigation and reference in modeling,control,and protection of the MMC-MTDC grids.A general overview of state-of-the-art modeling techniques of the MMC along with their performance in simulation analysis for MTDC applications is provided.A review of control strategies of the MMC-MTDC grids which provide AC system support is presented.State-of-the art protection techniques of the MMCMTDC systems are also investigated.Finally,the associated research challenges and trends are highlighted. | Lei Zhang Yuntao Zou Jicheng Yu Jiangchao Qin Vijay Vittal George G.Karady Di Shi Zhiwei Wang | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 17 |
| 3 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 4 | Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway显示文摘Influenza virus contains three integral membrane proteins:haemagglutinin,neuraminidase,and matrix protein(M1 and M2).Among them,M2 protein functions as an ion channel,important for virus uncoating in endosomes of virus-infected cells and essential for virus replication.In an effort to explore potential new functions of M2 in the virus life cycle,we used yeast two-hybrid system to search for M2-associated cellular proteins.One of the positive clones was identified as human Hsp40/Hdj1,a DnaJ/Hsp40 family protein.Here,we report that both BM2(M2 of influenza B virus)and A/M2(M2 of influenza A virus)interacted with Hsp40 in vitro and in vivo.The region of M2-Hsp40 interaction has been mapped to the CTD1 domain of Hsp40.Hsp40 has been reported to be a regulator of PKR signaling pathway by interacting with p58^(IPK) that is a cellular inhibitor of PKR.PKR is a crucial component of the host defense response against virus infection.We therefore attempted to understand the relationship among M2,Hsp40 and p58^(IPK) by further experimentation.The results demonstrated that both A/M2 and BM2 are able to bind to p58^(IPK)in vitro and in vivo and enhance PKR autophosphorylation probably via forming a stable complex with Hsp40 and P58^(IPK),and consequently induce cell death.These results suggest that influenza virus M2 protein is involved in p58^(IPK)mediated PKR regulation during influenza virus infection,therefore affecting infected-cell life cycle and virus replication. | Zhenhong Guan Di Liu Shuofu Mi Jie Zhang Qinong Ye Ming Wang George F.Gao Jinghua Yan | 2010 | Protein & Cell2010，1，10： | 11 |
| 5 | Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus显示文摘Influenza virus is the causative agent of the seasonal and occasional pandemic flu.The current H1N1 influenza pandemic,announced by the WHO in June 2009,is highly contagious and responsible for global economic losses and fatalities.Although the H1N1 gene segments have three origins in terms of host species,the virus has been named swine-origin influenza virus(S-OIV)due to a predominant swine origin.2009 S-OIV has been shown to highly resemble the 1918 pandemic virus in many aspects.Hemagglutinin is responsible for the host range and receptor binding of the virus and is therefore a primary indicator for the potential of infection.Primary sequence analysis of the 2009 S-OIV hemagglutinin(HA)reveals its closest relationship to that of the 1918 pandemic influenza virus,however,analysis at the structural level is necessary to critically assess the functional significance.In this report,we report the crystal structure of soluble hemagglutinin H1(09H1)at 2.9Å,illustrating that the 09H1 is very similar to the 1918 pandemic HA(18H1)in overall structure and the structural modules,including the five defined antiboby(Ab)-binding epitopes.Our results provide an explanation as to why sera from the survivors of the 1918 pandemics can neutralize the 2009 S-OIV,and people born around the 1918 are resistant to the current pandemic,yet younger generations are more susceptible to the 2009 pandemic. | Wei Zhang Jianxun Qi Yi Shi Qing Li Feng Gao Yeping Sun Xishan Lu Qiong Lu Christopher J.Vavricka Di Liu Jinghua Yan George F.Gao | 2010 | Protein & Cell2010，1，5： | 10 |
| 6 | Phylogenetics of varied subtypes of avian influenza viruses in China: potential threat to humans显示文摘 | Weifeng Shi Wei Li Xianbin Li Joel Haywood Juncai Ma George F.Gao Di Liu | 2014 | Protein & Cell2014，5，4： | 9 |
| 7 | Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015显示文摘A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015.Based on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin.The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of Africa.The affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean flyways.These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans. | Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing Jianqing Sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F. Gao | 2016 | Virologica Sinica2016，31，4： | 5 |
| 8 | Continuous reassortments with local chicken H9N2 virus underlie the human-infecting influenza A (H7N9) virus in the new influenza season, Guangdong, China显示文摘亲爱的编辑, | Wenbao Qi Weifeng Shi Wei Li Lihong Huang Huanan Li Ying Wu Jinghua Yan Peirong Jiao Baoli Zhu Juncai Ma George F. Gao Ming Liao Di Liu | 2014 | Protein & Cell2014，5，11： | 5 |
| 9 | Avian influenza A(H7N9)virus:from low pathogenic to highly pathogenic显示文摘OriginalTranslation The avian influenza A(H7N9)virus is a zoonotic virus that is closely associated with live poultry markets.It has caused infections in humans in China since 2013.Five waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017.H7N9 with low-pathogenicity dominated in the first four waves,whereas highly pathogenic H7N9 influenza emerged in poultry and spread to humans during the fifth wave,causing wide concern.Specialists and officials from China and other countries responded quickly,controlled the epidemic well thus far,and characterized the virus by using new technologies and surveillance tools that were made possible by their preparedness efforts.Here,we review the characteristics of the H7N9 viruses that were identified while controlling the spread of the disease.It was summarized and discussed from the perspectives of molecular epidemiology,clinical features,virulence and pathogenesis,receptor binding,T-cell responses,monoclonal antibody development,vaccine development,and disease burden.These data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging viruses,such as SARS-CoV-2. | William J.Liu Haixia Xiao Lianpan Dai Di Liu Jianjun Chen Xiaopeng Qi Yuhai Bi Yi Shi George F.Gao Yingxia Liu | 2021 | Frontiers of Medicine2021，15，4： | 4 |
| 10 | The first pulsar discovered by FAST显示文摘To assist with the commissioning [1] of the Five-hundredmeter Aperture Spherical radio Telescope (FAST), we performed a pulsar search, with the primary goal of developing and testing the pulsar data acquisition and processing pipelines. We tested and used three pipelines, two (Pl and P2 hereafter) searched for the periodic signature of pulsars whereas the other one was used to search for bright single pulses (P3 hereafter). | Lei Qian ZhiChen Pan Di Li George Hobbs WeiWei Zhu Pei Wang ZhiJie Liu YouLing Yue Yan Zhu HongFei Liu DongJun Yu JingHai Sun Peng Jiang GaoFeng Pan Hui Li HengQian Gan Rui Yao XiaoYao Xie Fernando Camilo Andrew Cameron Lei Zhang Shen Wang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 3 |
| 11 | Reconfiguring wireless environments via intelligent surfaces for 6G:reflection,modulation,and security显示文摘The reconfigurable intelligent surface(RIS)has been recognized as an essential enabling technology for sixth-generation(6G)mobile communication networks.An RIS comprises a large number of small and low-cost reflecting elements whose parameters can be dynamically adjusted with a programmable controller.Each of these elements can effectively reflect a phase-shifted version of the incident electromagnetic wave.By configuring the wave phases in real time,the propagation environment of the information-bearing signals can be dynamically manipulated to enhance communication reliability,boost transmission rate,expand cellular coverage,and strengthen communication security.In this study,we provide an overview on RIS-assisted wireless communications.Specifically,we elaborate on the state-of-the-art enabling techniques for the RIS technology as well as their corresponding substantial benefits from the perspectives of RIS reflection and RIS modulation.With these benefits,we envision the integration of RISs into emerging applications for 6G.In addition,communication security is of unprecedented importance in future 6G networks with ubiquitous wireless services in multifarious verticals and areas.We highlight potential contributions of RISs to physical-layer security,in terms of secrecy rate and secrecy outage probability,exemplified by a typical case study from both theoretical and numerical aspects.Finally,we discuss challenges and opportunities on the deployment of RISs in practice to motivate future research. | Jindan XU Chau YUEN Chongwen HUANG Naveed UL HASSAN George CALEXANDROPOULOS Marco DI RENZO Mérouane DEBBAH | 2023 | Science China(Information Sciences)2023，66，3： | 3 |
| 12 | The new emerging H7N9 influenza virus indicates poultry as new mixing vessels显示文摘Since 30 March 2013,the Chinese Center for Disease Control and Prevention(China CDC)has reported the first laboratory-confirmed cases of influenza A H7N9 virus human infection.This new pathogen caused 144 human infections with 47 fatal cases in year 2013,and continued to bring another wave in 2014,caused another 273 infections with 108deaths as of 27th April.The H7N9 influenza virus has again raised the global concerns of the potential pandemics.Studies of the origin and evolution of this virus revealed that the novel H7N9 influenza virus was reassorted from H7,N9and H9N2 subtypes of influenza viruses from domestic ducks,wild waterfowls and poultry,respectively;and the processes of genetic reassortments were sequential and dynamic[1?3]. | LIU Di GAO George F. | 2014 | Science China(Life Sciences)2014，57，7： | 3 |
| 13 | Telbivudine Improves Renal Function in Patients With Chronic Hepatitis B显示文摘 | Edward J. Gane Gilbert Deray Yun-Fan Liaw Seng Gee Lim Ching-Lung Lai Jens Rasenack Yuming Wang George Papatheodoridis Adrian Di Bisceglie Maria Buti Didier Samuel Alkaz Uddin Sophie Bosset Aldo Trylesinski | 2014 | Gastroenterology2014，，1： | 2 |
| 14 | MicroRNA-181b通过调节金属蛋白酶组织抑制因子3和弹性蛋白影响动脉粥样硬化和动脉瘤显示文摘动脉粥样硬化和动脉瘤是全世界人口的主要致死原因。微小RNA(microRNAs,miR)是基因和蛋白表达的关键决定因素,miR异常表达与许多心血管病有关。目前对它们在动脉粥样硬化斑块和腹主动脉瘤(abdominal aortic aneurysm,AAA)稳定性中的作用了解甚少。 | 刘莉 叶鹏 Di Gregoli K Mohamad Anuar NN Bianco R White SJ Newby AC George SJ Johnson JL | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 15 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 2 |
| 16 | PNPLA 3 rs738409 I748M is associated with steatohepatitis in 434 non‐obese subjects with hepatitis C显示文摘 | S. Petta E. Vanni E. Bugianesi C. Rosso D. Cabibi C. Cammà V. Di Marco M. Eslam S. Grimaudo F. S. Macaluso D. McLeod R. M. Pipitone M. L. Abate A. Smedile J. George A. Craxì | 2015 | Aliment Pharmacol Ther2015，，10： | 2 |
| 17 | An unexpected similarity between antibiotic-resistant NDM-1 and beta-lactamaseⅡfrom Erythrobacter litoralis显示文摘NDM-1(New Delhi metallo-beta-lactamase)gene encodes a metallo-beta-lactamase(MBL)with high carbapenemase activity,which makes the host bacterial strain easily dispatch the last-resort antibiotics known as carbapenems and cause global concern.Here we present the bioinformatics data showing an unexpected similarity between NDM-1 and beta-lactamase II from Erythrobacter litoralis,a marine microbial isolate.We have further expressed these two mature proteins in E.coli cells,both of which present as a monomer with a molecular mass of 25 kDa.Antimicrobial susceptibility assay reveals that they share similar substrate specificities and are sensitive to aztreonam and tigecycline.The conformational change accompanied with the zinc binding visualized by nuclear magnetic resonance,Zn2+-bound NDM-1,adopts at least some stable tertiary structure in contrast to the metal-free protein.Our work implies a close evolutionary relationship between antibiotic resistance genes in environmental reservoir and in the clinic,challenging the antimicrobial resistance monitoring. | Beiwen Zheng Shuguang Tan Jia Gao Huiming Han Jun Liu Guangwen Lu Di Liu Yong Yi Baoli Zhu George F.Gao | 2011 | Protein & Cell2011，2，3： | 2 |
| 18 | Endoscopic ultrasound fine needle aspiration:Technique and applications in clinical practice显示文摘Since its initial report in 1992,endoscopic ultrasoundguided fine needle aspiration(EUS-FNA) has now been incorporated into the diagnostic and staging algorithm for the evaluation of benign and malignant diseases of the gastrointestinal tract and of adjacent organs.Its introduction constitutes a major breakthrough in the endoscopic field and has gradually transformed EUS from a pure imaging modality into a more interventional procedure.In addition,the possibility of collecting samples,providing a definitive cytological and/or histological evidence of the presence of malignancy,has strongly contributed to changing EUS from a subjective,highly operator dependant procedure into a more objective one.This article will review the instrumentation,technique and the most important clinical applications of EUS-FNA. | Benjamin Tharian Fotios Tsiopoulos Nayana George Salvatore Di Pietro Fabia Attili Alberto Larghi | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，12： | 2 |
| 19 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 1 |
| 20 | Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains显示文摘 | Peipei Liu Di Liu Xi Yang Jing Gaoai Ma3, Fangqing Zhaos, Xuyu Zhou~'2~, George F. Gao1'2'4'5~, Baoli Zhu~'2~ Yan Chen Xue Xiao Fei Liu Jing Zou Jun Wu Juncai Ma Fangqing Zhao Xuyu Zhou George F. Gao Baoli Zhu | 2014 | Protein & Cell2014，5，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员