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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Dihydroartemisinin is an inhibitor of ovarian cancer cell growth显示文摘瞄准:调查 dihydroartemisinin (DHA ) 的反癌症活动,在人的卵巢的癌症房间的一块面板的反疟疾药 artemisinin 的衍生物排队。方法: 房间生长被 MTT 生存能力试金决定。Apoptosis 和房间周期前进被 DNA 破碎胶化电气泳动,流动 cytometry 试金,和 TUNEL 试金评估;蛋白质和 mRNA 表示被西方的弄污和 RT-PCR 试金分析。结果:Artemisininand 它的衍生物包括 artesunate, arteether, artemether, arteannuin,和 DHA,在人的卵巢的癌症细胞的 exhibitanticancer 生长活动。在他们之中, DHA 在禁止房间生长是最有效的。卵巢的癌症房间线是更敏感的(5-10-fold ) 到与正常相比的 DHA 治疗,卵巢的房间排队。在微臼齿的剂量层次的 DHA 展出剂量 -- 在卵巢的癌症房间的 andtime 依赖的 cytotoxicity 排队。而且, DHA 导致了 apoptosis 和 G2cell 周期拘捕,由 Bcl-xL 和 Bcl-2 和 Bax 和 Bad.Conclusion 的增加的减少伴随了:有希望的结果第一次证明 DHA 禁止人的卵巢的癌症房间的生长。房间生长, apoptosis 正式就职,和 G2 拘捕在卵巢的癌症的临床的治疗作为可能的反癌症药为 DHA 的进一步的研究在 vitro 证据提供的卵巢的癌症的选择抑制。 | Yang JIAO Chun-min GE Qing-hui MENG Jian-ping CAO Jian TONG Sai-jun FAN | 2007 | Acta Pharmacologica Sinica2007，28，7： | 39 |
| 3 | 电针和经皮穴位电刺激技术在生殖医学中的应用:专家共识(英文)显示文摘本文从传统针刺治疗不孕症的选穴依据与现代电针/经皮穴位电刺激技术的相关原理着手,从最优刺激参数选择、穴位辨证、疗程与治疗次数的确定及基本原理等方面阐述了电针/经皮穴位电刺激技术在多囊卵巢综合症、取卵镇痛、卵巢储备功能降低、胚胎移植以及男性少/弱精症等生殖领域中的具体应用。首次对电针/经皮穴位电刺激技术在生殖领域优势病种中的应用进行了系统的分析和总结,在最优刺激参数选择、穴位辨证、疗程与治疗次数的确定等方面提出了一系列专家共识,并为临床实践提供了指导意见和理论依据。 | Fan QU Rong LI Wei SUN Ge LIN Rong ZHANG Jing YANG Li TIAN Guo-gang XING Hui JIANG Fei GONG Xiao-yan LIANG Yan MENG Jia-yin LIU Li-ying ZHOU Shu-yu WANG Yan WU Yi-jing HE Jia-yu YE Song-ping HAN Ji-sheng HAN | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 24 |
| 4 | Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation显示文摘 | Bin LU Xu GONG Zong-qi WANG Ye DING Chen WANG Tian-fei LUO Mei-hua PIAO Fan-kai MENG Guang-fan CHI Yi-nan LUO Peng-fei GE | 2017 | Acta Pharmacologica Sinica2017，38，11： | 22 |
| 5 | Overexpression of p27^(KIP1)induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell line显示文摘AIM We have previously reported that inducibleover-expression of Bak may prolong cell cycle inG1 phase and lead to apoptosis in HCC-9204 cells.This study is to investigate whether p27KIP1playsan important role in this process.METHODS In order to elucidate the exactfunction of p27KIP1in this process,a zinc induciblep27KIP1stable transfectant and transient p27KIP1-GFP fusion transfectant were constructed.Theeffects of inducible,p27KIP1on cell growth,cellcycle arrest and apoptosis were examined in themock,control pMD vector,and pMD-KIP1transfected HCC-9204 cells.RESULTS This p27KIP1-GFP transfectant maytransiently express the fusion gene.The cellgrowth was reduced by 35% at 48 h of p27KIP1induction with zinc treatment as determined bytrypan blue exclusion assay.These differencesremained the same after 72 h of p27KIP1expression,p27KIP1caused cell cycle arrest after24 h of induction,with 40% increase in G1population.Prolonged p27KIP1expression in thiscell line induced apoptotic cell death reflected byTUNEL assay.Fourty-eight h and 72 h of p27KIP1expression showed a characteristic DNA ladder onagarose gel electrophoresis. CONCLUSION Bak may induce cell cycle arrest inG1 phase through upregulating expression ofp27KIP1and subsequently lead to apoptosis inHCC-9204 cells.The p27KIP1-GFP fusion proteincan be transiently expressed in HCC-9204 cells.The inducible p27KIP1-expressing cell line providesa model to assess p27KIP1function. | Jiang Li Xin Ke Yang Xin Xin Yu Meng Liang Ge Wen Liang Wang Jie Zhang Yun De Hou Department of Pathology,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China State Key Laboratory for Molecular Virology and Genetic Engineering,Beijing 100052,China Department of Dermatology,Beijing Hospital,Beijing 100016,China Institute of Radiation Medicine,Beijing 100085,China | 2000 | World Journal of Gastroenterology2000，6，4： | 20 |
| 6 | Influencing factors of seismic signals generated by un-tuned large volume airgun array in a land reservoir显示文摘Un-tuned large volume airgun array in a water reservoir is recently proposed as a new way to generate seismic waves on land. It can be used to explore the earth velocity structure and its temporal variations as well.However, the characteristics of seismic signals(especially far-field signals) from an airgun array in a reservoir and its affecting factors(firing pressure, airgun towing depth,water level of the reservoir, etc.) has not been adequately studied. We analyzed the seismic data collected from field experiments at Binchuan Transmitting Seismic Station in2011 and 2013 and found that(1) The similarity of seismic signals decrease with distance, which is most likely induced by the decay of signal amplitude and signal to noise ratio(SNR);(2) The amplitudes of far-field airgun signals are almost linearly proportional to the firing pressure;(3) The towing depth of airgun has less effects on the far-field signals;(4) The amplitudes of far-field airgun signals are proportional to the water level of the reservoir. | Meng Chen Wei Yang Weitao Wang Baoshan Wang Hongkui Ge Li Chen Yansheng Ding Jiyan Qiao Yong Chen | 2014 | Earthquake Science2014，27，4： | 19 |
| 7 | Cyclic Sequences, Events and Evolution of the Sino-Korean Plate, with a Discussion on the Evolution of Molar-tooth Carbonates, Phosphorites and Source Rocks显示文摘This paper gives an account of the research that the authors conducted on the cyclic sequences, events and evolutionary history from Proterozoic to Meso-Cenozoic in the Sino-Korean plate based on the principle of the Cosmos-Earth System. The authors divided this plate into 20 super-cyclic or super-mega-cyclic periods and more than 100 Oort periods. The research focused on important sea flooding events, uplift interruption events, tilting movement events, molar-tooth carbonate events, thermal events, polarity reversal events, karst events, volcanic explosion events and storm events, as well as types of resource areas and paleotectonic evolution. By means of the isochronous theory of the Cosmos-Earth System periodicity and based on long-excentricity and periodicity, the authors elaborately studied the paleogeographic evolution of the aulacogen of the Sino-Korean plate, the oolitic beach platform formation, the development of foreland basin and continental rift valley basin, and reconstructed the evolution of tectonic paleogeography and stratigraphic framework in the Sino-Korean plate in terms of evolutionary maps. Finally, the authors gave a profound discussion on the formation and development of molar-tooth carbonates, phosphorites and source rocks. | MENG Xianghua and GE MingInstitute of Sedimentary Basin, China University of Geosciences, Beijing 100083 E-mail: mengxh@cugb.edu.cn Liu Xinzhu and Zhu Xiling | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 17 |
| 8 | Double-stream-pouring technique for production of gradient materials by continuous casting显示文摘A novel method for producing gradient materials by continuous casting is introduced. By using many-stream-pouring technique, samples with gradient distribution of alloy composition along the cross section have been prepared. The main difference of this method from the conventional continuous casting is the pouring system equipped with two sets of tundishes for liquid metals of different alloy compositions. Special consideration is given to the promotion and control of the cross-sectional mass transport. The steady heat transfer and mass flow ensure a partial mixing of two metals and yield a continously varying composition distribution. By adjusting the processing parameters, composition profile with different shapes can be achieved. First experiments have been carried out in Al-Si system and Al-Cu system for three series of Al/AlSi, AlSi/Al and AlCu/Al. It is shown that the alloy composition, the microstructure and the mechanical property change smoothly from the centre to the surface of the samples. This simple and practical method is potential for mass prodution of 'structural gradient materials' and may offer a new way for alloy design. | Zhang Weiwen Zhu Cangshan Wei Xingzhao Meng Jilong Yuan Shugui Yu Ge | 1998 | Chinese Science Bulletin1998，43，11： | 16 |
| 9 | Experimental investigation of shale imbibition capacity and the factors influencing loss of hydraulic fracturing fluids显示文摘Spontaneous imbibition of water-based fracturing fluids into the shale matrix is considered to be the main mechanism responsible for the high volume of water loss during the flowback period. Understanding the matrix imbibition capacity and rate helps to determine the fracturing fluid volume, optimize the flowback design, and to analyze the influences on the production of shale gas.Imbibition experiments were conducted on shale samples from the Sichuan Basin, and some tight sandstone samples from the Ordos Basin. Tight volcanic samples from the Songliao Basin were also investigated for comparison. The effects of porosity, clay minerals, surfactants, and KCl solutions on the matrix imbibition capacity and rate were systematically investigated. The results show that the imbibition characteristic of tight rocks can be characterized by the imbibition curve shape, the imbibition capacity, the imbibition rate, and the diffusion rate. The driving forces of water imbibition are the capillary pressure and the clay absorption force. For the tight rocks with low clay contents,the imbibition capacity and rate are positively correlated with the porosity. For tight rocks with high clay content,the type and content of clay minerals are the most important factors affecting the imbibition capacity. The imbibed water volume normalized by the porosity increases with an increasing total clay content. Smectite and illite/smectite tend to greatly enhance the water imbibition capacity.Furthermore, clay-rich tight rocks can imbibe a volume ofwater greater than their measured pore volume. The average ratio of the imbibed water volume to the pore volume is approximately 1.1 in the Niutitang shale, 1.9 in the Lujiaping shale, 2.8 in the Longmaxi shale, and 4.0 in the Yingcheng volcanic rock, and this ratio can be regarded as a parameter that indicates the influence of clay. In addition,surfactants can change the imbibition capacity due to alteration of the capillary pressure and wettability. A 10wt% KCl solution can inhibit clay absorption to reduce the imbibition capacity. | Hong-Kui Ge Liu Yang Ying-Hao Shen Kai Ren Fan-Bao Meng Wen-Ming Ji Shan Wu | 2015 | Petroleum Science2015，12，4： | 13 |
| 10 | Vagus Nerve Stimulation for Pediatric and Adult Patients with Pharmaco-resistant Epilepsy显示文摘 | Fan-Gang Meng Fu-Min Jia Xiao-Hui Ren Yan Ge Kai-Liang Wang Yan-Shan Ma Ming Ge Kai Zhang Wen-Han HU Xin Zhang Wei Hu Jian-Guo Zhang | 2015 | Chinese Medical Journal2015，，19： | 13 |
| 11 | Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma:a single-center,single-arm,phase 2 study显示文摘Advanced intrahepatic cholangiocarcinoma(ICC)has a dismal prognosis.Here,we report the efficacy and safety of combining toripalimab,lenvatinib,and gemcitabine plus oxaliplatin(GEMOX)as first-line therapy for advanced ICC.Thirty patients with pathologically confirmed advanced ICC received intravenous gemcitabine(1 g/m2)on Days 1 and 8 and oxaliplatin(85 mg/m2)Q3W for six cycles along with intravenous toripalimab(240 mg)Q3W and oral lenvatinib(8 mg)once daily for one year.The expression of programmed death-ligand 1(PD-L1)and genetic status was investigated in paraffin-embedded tissues using immunohistochemistry and whole-exome sequencing(WES)analysis.The primary endpoint was the objective response rate(ORR).Secondary outcomes included safety,overall survival(OS),progression-free survival(PFS),disease control rate(DCR)and duration of response(DoR).As of July 1,2022,the median follow-up time was 23.5 months,and the ORR was 80%.Twenty-three patients achieved partial response,and one achieved complete response.Patients(21/30)with DNA damage response(DDR)-related gene mutations showed a higher ORR,while patients(14/30)with tumor area positivity≥1(PD-L1 staining)showed a trend of high ORR,but without significant difference.The median OS,PFS,and DoR were 22.5,10.2,and 11.0 months,respectively.The DCR was 93.3%.Further,56.7%of patients experienced manageable grade≥3 adverse events(AEs),commonly neutropenia(40.0%)and leukocytopenia(23.3%).In conclusion,toripalimab plus lenvatinib and GEMOX are promising first-line regimens for the treatment of advanced ICC.A phase-III,multicenter,double-blinded,randomized study to validate our findings was approved by the National Medical Products Administration(NMPA,No.2021LP01825). | Guo-Ming Shi Xiao-Yong Huang Dong Wu Hui-Chuan Sun Fei Liang Yuan Ji Yi Chen Guo-Huan Yang Jia-Cheng Lu Xian-Long Meng Xin-Ying Wang Lei Sun Ning-Ling Ge Xiao-Wu Huang Shuang-Jian Qiu Xin-Rong Yang Qiang Gao Yi-Feng He Yang Xu Jian Sun Zheng-Gang Ren Jia Fan Jian Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 12 |
| 12 | Adenovirus-mediated expression of Tob1 sensitizes breast cancer cells to ionizing radiation显示文摘瞄准:调查 Tob1 基因的效果, ErbB2/B-cell 易位 Ggene (TOB/BTG ) 家庭的 Transducing 分子的一个成员,由在一个人在放射敏感度上使用 Tob1 的调停侵入人体气管粘膜的病菌的表示,乳癌房间衬里 MDA-MB-231。方法:房间幸存被 clonogenic 试金决定。Apoptosis 被 DNA 破碎胶化电气泳动和终端 deoxynucleotidyl 评估调停 transferase 的刻痕结束标记试金。蛋白质表示被西方的污点试金分析, DNA 修理被主人房间复活试金测量。结果:我们证明有 Ad5-Tob1 的照耀前治疗显著地增加了放射敏感度,伴随 apoptosis 的增加的正式就职和 DNA 损坏修理的压抑。而且, Ad5-Tob1-mediated 放射敏感度相关与起来 pro-apoptotic 蛋白质 Bax 的规定并且下面几 DNA 双海滨裂缝修理蛋白质,包括的 DNA 依赖的蛋白质家族 ases, Ku70 和 Ku80 的规定,和 X-ray-sensitive 互补组织 4。结论:作为新收音机抗体, Tob1 是在经由增加 apoptosis 并且压制 DNA 修理的乳癌的放射疗法的一个新目标。 | Yang JIAO Chun-min GE Qing-hui MENG Jian-ping CAO Jian TONG Sai-jun FAN | 2007 | Acta Pharmacologica Sinica2007，28，10： | 12 |
| 13 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 14 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 15 | Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells显示文摘 | Peng-fei GE Ji-zhou ZHANG Xiao-fei WANG Fan-kai MENG Wen-chen LI Yong-xin LUAN Feng LING Yi-nan LUO | 2009 | Acta Pharmacologica Sinica2009，30，7： | 11 |
| 16 | Use of tailored loading-dose clopidogrel in patients undergoing selected percutaneous coronary intervention based on adenosine diphosphate-mediated platelet aggregation显示文摘背景腺苷调停磷酸盐的血小板聚集是为在经历了选择经皮的冠的干预的病人的主要不利心脏的事件的一个预示的因素。试图估计 clopidogrel 的调整装载剂量是否能更有效地在经历的病人禁止血小板聚集的这研究选择了经皮的冠的 intervention.Methods 经历选择经皮的冠的干预的 205 个病人的一个总数在这 multicenter 被注册,未来的、使随机化的学习。收到国内 clopidogrel (n=104 ) 的病人担任了 Talcom (Taijia ) 组;其它(n=101 ) 收到了 Plavix, Plavix 组,病人们收到了腺苷直到装载 clopidogrel 的剂量到减少的 3 另外的 300-mg 在超过 50% 的调停磷酸盐的血小板聚集索引(主要端点) 与基线相比。第二等的端点与合理装载剂量相比是在 12 months.Results 的主要不利心血管的事件,定制的装载剂量更好在腺苷基于 50% 减少禁止了血小板聚集调停磷酸盐的血小板聚集(合理装载剂量对定制的装载剂量, 48% 对 73% , P=0.028 ) 。在在 Talcom 和 Plavix 组之间的合格索引没有重要差别(47% 对 49% 在 300 mg;62% 对 59% 在 600 mg;74% 对 72% 在 900 mg;P 0.05 ) 基于标准腺苷 50% 的调停 diphosphate 的血小板聚集减少。在 12 月后续以后,在主要不利心脏的事件没有重要差别(2.5% 对 2.9% , P=5.43 ) 。没有尖锐或稍尖的 stent 血栓事件 occurred.Conclusion clopidogrel 的调整装载剂量能与合理剂量相比在 antiplatelet 聚集上有重要效果,减少的 1 年的专业在基于腺苷经历经皮的冠的干预的病人的不利心脏的事件没有流血的增加的调停磷酸盐的血小板聚集。 | MENG Kang LV Shu-zheng ZHU Hua-gang CHEN Xin GE Chang-jiang SONG Xian-tao | 2010 | Chinese Medical Journal2010，，24： | 11 |
| 17 | Combined effect of atorvastatin and probucol on plasma cystatin C levels and severity of coronary lesion in patients with borderline coronary lesion显示文摘 | GE Chang-jiang LU Shu-zheng FENG Li-xia HUO Yong SONG Xian-tao CHEN Xin MENG Kang YUAN Fei | 2012 | Chinese Medical Journal2012，，14： | 10 |
| 18 | Performance optimization of a class of combined thermoelectric heating devices显示文摘A detailed model of thermally-driven combined thermoelectric(TE) heating device is established. The device consists of twostage TE heat pump(TTEH) and two-stage TE generator(TTEG) with four external heat exchangers(HEXs). Both internal losses and external heat transfer irreversibilities are considered in the model. The heating capacity and the coefficient of performance(COP) of the device are improved through numerical optimization,which is of great significance to the application of the device. The distribution of the total TE element number among four TE devices and the distribution of the total external heat conductance among the four external HEXs are optimized. The results show that both the reservoir temperatures of TTEG and TTEH have significant influences on the performance and the corresponding optimum parameters of the device. The COP can reach 0.14 after optimization when the temperature difference of heat source is 150 K and the temperature difference of heating is 10 K. | CHEN LinGen MENG FanKai GE YanLin FENG HuiJun XIA ShaoJun | 2020 | Science China(Technological Sciences)2020，63，12： | 10 |
| 19 | Characteristics of the HIV/AIDS Epidemic in Women Aged 15-49 Years from 2005 to 2012 in China显示文摘Objective To describe the characteristics of the HIV/AIDS epidemic in women aged 15-49 years in China. Methods HIV/AIDS cases from 2005 to 2012 that fulfilled the inclusion and exclusion criteria were identified on the Chinese HIV/AIDS case reporting system. Descriptive and spatial analyses were performed. Results A total of 103,559 female HIV/AIDS cases were included in our study. Based on the descriptive analysis, between 2005 and 2012, the proportion of heterosexually acquired HIV infection among women(15-49 years) increased rapidly from 35.8% to 87.4%. Approximately 60% of these cases were infected through non-marital heterosexual contact. Among older women(40-49 years), a slightly increasing trend was identified. The spatial analysis detected ‘hot spots' in the Xinjiang, Yunnan, Sichuan, Guangxi, and Chongqing provinces. The epidemic trends in these areas were predominately driven by heterosexual transmission. Conclusion Non-marital heterosexual contact is a very important factor in the HIV/AIDS epidemic in women aged 15-49 years, and the HIV infection rate in older women is increasing. Several epidemic hot spots were detected in northwestern and southwestern China. Efficient interventions are needed to control the spread of HIV/AIDS among women living in these areas. | ZHANG Xia Yan HUANG Tao FENG Yi Bing LI Meng CHEN Fang Fang LI Yin Ge JIN Shan Shan BU Kai WANG Lu | 2015 | Biomedical and Environmental Sciences2015，28，10： | 10 |
| 20 | First-in-man Implantation of the XINSORB Bioresorbable Sirolimus-eluting Scaffold in China显示文摘To the Editor:A 35-year-old man who smoked for 15 years suffered from chest pain 12 days ago before admission.He was diagnosed as myocardial infarction.Thrombolytic therapy was given consequently.The electrocardiogram showed sub-acute inferior wall myocardial infarction.Echocardiogram showed attenuated constriction of the inferior wall with an ejection fraction of 59%.On September 5,2013,he was treated with a XINSORB scaffold in right coronary artery (RCA). | Jia-Hui Chen Yi-Zhe Wu Li Shen Feng Zhang Zhi-Feng Yao Jia-Sheng Yin Meng Ji Qi-Bing Wang Lei Ge Ju-Ying Qian Xi Hu Jian Xie Jun-Bo Ge | 2015 | Chinese Medical Journal2015，，9： | 10 |
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