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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | A strategy for greenhouse climate control,Part Ⅰ:Model development显示文摘 | Trigui M Barrington S Gauthier L | 2001 | Journal of Agricultural Engineering Research2001，78，4： | 1 |
| 3 | Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia:a pilot randomized controlled trial显示文摘 | Rey E Garneau P David M Gauthier R Leduc L Michon N | 2009 | J Thromb Haemost2009，7，1： | 1 |
| 4 | Three-dimensional growth of differentiating MC3T3-E1 pre-osteoblasts on porous titanium scaffolds显示文摘 | St-Pierre J P Gauthier M Lefebvre L P | 2005 | Biomaterials2005，26，35： | 1 |
| 5 | Chemotherapy of advanced small- bowel adenocarcinoma:a multicenter AGEO study显示文摘 | Zaanan A Costes L Gauthier M | 2010 | Ann Oncol2010，21，9： | 1 |
| 6 | A strategy for green- house climate control 显示文摘 | Trigui M Barrington S Gauthier L | 2001 | Journal of Agricultural Engineer- ing Research2001，78，： | 1 |
| 7 | Protein kinase C anegatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor 显示文摘 | Gauthier M L Torretto C Ly J | 2003 | Biochem Biophys Res Commun2003，307，4： | 1 |
| 8 | Relationship between cloud-to-ground lightning and precipitation ice mass:A radar study over Houston显示文摘 | GAUTHIER M L PETERSEN W A CAREY L D et a1 | | 0，，： | 1 |
| 9 | Seasonal prevalence of pathogens and parasites in the savannah honeybee(Apis mellifera scutellata)显示文摘 | Strauss U Human H Gauthier L Crewe R M Dietemann V Pirk C W | 2013 | J Invertebr Pathol2013，114，1： | 1 |
| 10 | Radiation dose in interventional cardiology procedures :urgent need for monitoring dose and establishing diagnostic reference levels 显示文摘 | Mercuri M Moran GR Gauthier L | 2008 | Heahhc Q2008，11，1： | 1 |
| 11 | W-band finite ground coplanar waveguide ( FGCPW ) to microstrip linetransition 显示文摘 | Gauthier G P Katehi L P Rebeiz G M | 1998 | IEEE MTT-S International Microwave Symposium Digest1998，1，： | 1 |
| 12 | Cell mergers and their impact on cloud-to-ground lightning over the Houston area显示文摘 | Gauthier M L Petersen W A Carey L D | 2010 | Atmospheric Research2010，96，4： | 1 |
| 13 | A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B-lymphocytes 显示文摘 | Milili M Gauthier L Veran J | 2002 | Immunology2002，106，4： | 1 |
| 14 | Chemotherapy of advancedsmall-bowel adenocarcinoma: a multicenter AGEO study 显示文摘 | Zaanan A Costes L Gauthier M | 2010 | AnnOncol2010，21，9： | 1 |
| 15 | Amphibian micronucleus test (s):a simple and reliable method for evaluating in vivo genotoxic effects of freshwater pollutants and radiations显示文摘 | Fernandez M Haridon J Gauthier L | 1993 | Mutat Res1993，292，： | 1 |
| 16 | Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium显示文摘 | Shim V Gauthier M L Sudilovsky D | 2003 | Cancer Res2003，63，10： | 1 |
| 17 | Effects of humidity on tomato water uptake, yield, and dehumidification cost显示文摘 | Trigui M Barrington S F Gauthier L | 1999 | Canadian Agricultural Engineering1999，41，3： | 1 |
| 18 | Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli 显示文摘 | Gauthier A Robertson M L Lowden M | 2005 | Antimicrob Agents Chemother2005，49，10： | 1 |
| 19 | Evaluation of left visuospatial neglect:norms and discrimination power of two tests显示文摘 | Vanier M Gauthier L Lambert J | 1990 | Neuropsychology1990，4，2： | 1 |
| 20 | Efficacy of two mandibular advancement appliances in the manage- ment of snoring and mild-moderate sleep apnea: a cross- over randomized study 显示文摘 | Gauthier L Laberge L Beaudry M | 2009 | Sleep Medicine2009，10，3： | 1 |
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