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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Radiometric correction of visible and infrared remote sensing data at the Canada Centre for Remote Sensing显示文摘 | AHERN F J Brown R J Cihlar J Gauthier R Murphy J Neville R A and Teillet P M | 1984 | International Journal of Remote Sensing1984，8，： | 2 |
| 3 | AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance显示文摘 | Gauthier M S Miyoshi H Souza S C | 2008 | J Biol Chem2008，283，24： | 1 |
| 4 | A strategy for greenhouse climate control,Part Ⅰ:Model development显示文摘 | Trigui M Barrington S Gauthier L | 2001 | Journal of Agricultural Engineering Research2001，78，4： | 1 |
| 5 | Acetylcholine-induced relaxations of rabbit small mesenteric arteries: role of arachidonic acid metabolites and K+ 显示文摘 | Zhang D X Gauthier K M Chawengsub Y | 2007 | Am J Physiol Heart Cite Physiol2007，293，1： | 1 |
| 6 | Fractionation of whey' protein hydrolysates using charged UF/NF membranes显示文摘 | Pouliot Y Wijers M C Gauthier S F | 1999 | Journal of Membrane Science1999，158，： | 1 |
| 7 | A strategy for greenhouse climate control, Part Ⅰ: Model development显示文摘 | Trigui M Barrington S Gauthier M | 2001 | Journal of Agricultural Engineering Research2001，78，4： | 1 |
| 8 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry 显示文摘 | ZAGHIB K RAVET N GAUTHIER M GENDRON F MAUGER A GOODENOUGH J B JULIEN C M | 2006 | Journal of Power Sources2006，163，： | 1 |
| 9 | Evaluation of side information effectiveness in distributed video coding 显示文摘 | CAGNAZZO M MAUGEY T GAUTHIER J | 2013 | IEEE Transactions on Circuits and Systems for Video Technology2013，23，12： | 1 |
| 10 | Electrochemistry of anodes in solid-state Li-ion polymer batteries显示文摘 | ZAGHIB K ARMAND M GAUTHIER M J | 1998 | Electrochem Soc1998，145，9： | 1 |
| 11 | The mel- anocytorrhagic hypothesis of vitiligo tested on pigmented, stressed, reconstructed epidermis 显示文摘 | CARLO- ANDR_E M PAIN C GAUTHIER Y | 2007 | Pigment Cell Res2007，20，5： | 1 |
| 12 | Comparison of bifidobacterial growth-promoting activity of ultrafiltered casein hydrolyzate fractions 显示文摘 | Proulx M Ward P Gauthier S F | 1994 | Lait1994，74，： | 1 |
| 13 | Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia:a pilot randomized controlled trial显示文摘 | Rey E Garneau P David M Gauthier R Leduc L Michon N | 2009 | J Thromb Haemost2009，7，1： | 1 |
| 14 | Evaluation of tooth-click triggering and speech recognition in assistive tech- nology for computer access 显示文摘 | Simpson T Gauthier M Prochazka A | 2010 | Neurorehabil Neural Repair2010，24，2： | 1 |
| 15 | Crosslinkable polymers for nanocrystal stabilization显示文摘 | Fuhrmann K Gauthier M A Leroux J C | 2010 | J Contr Rel2010，148，： | 1 |
| 16 | Comparison of bifidobacterial growth-promoting activity of ultrafihered casein hvdrolvzate fractions显示文摘 | Proulx M Ward P Gauthier S F | 1994 | Lair1994，74，2： | 1 |
| 17 | Effects of Sublethal Doses of Fipronil on the Behavior of the Honeybee (Apis mellifera)显示文摘 | EL HASSANI A K DACHER M GAUTHIER M | 2005 | Pharmacology Biochemistry and Behavior2005，82，： | 1 |
| 18 | Mechanism of the Fe^3+ reduction at low temperature for LiFePO4 synthesis from a polymeric additive 显示文摘 | Ravet N Gauthier M Zaghib K Goodenough J B | 2007 | Chem Mater2007，19，： | 1 |
| 19 | Impact of a 12-month exercise program on the physical and psychological health of osteopenic women显示文摘 | Bravo G Gauthier P Roy P M | 1996 | J Am Geriatr Soc1996，44，： | 1 |
| 20 | Arborescent polystyrene-graft-poly(2-vinylpyridine) copolymers as unimolecular micelles: solubilization studies显示文摘 | Njikang G Gauthier M Li J | 2008 | Polymer2008，49，5： | 1 |
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