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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Radiometric correction of visible and infrared remote sensing data at the Canada Centre for Remote Sensing显示文摘 | AHERN F J Brown R J Cihlar J Gauthier R Murphy J Neville R A and Teillet P M | 1984 | International Journal of Remote Sensing1984，8，： | 2 |
| 3 | Efficacy of galantamine improbable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial显示文摘 | Erkinjuntti Kurz A Gauthier S | 2002 | Lancet2002，359，9314： | 1 |
| 4 | Friedel-Crafts acylation of toluene and p-xylene with carboxylic acids catalyzed by zeolites显示文摘 | Finiels A Gauthier C | 1986 | J Org Chem1986，51，： | 1 |
| 5 | An in situ target strength model for Atlantic redfish 显示文摘 | Gauthier S Rose G A | 1998 | Journal of the Acoustical Society of America1998，103，5： | 1 |
| 6 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry 显示文摘 | ZAGHIB K RAVET N GAUTHIER M GENDRON F MAUGER A GOODENOUGH J B JULIEN C M | 2006 | Journal of Power Sources2006，163，： | 1 |
| 7 | Circadian rhythms in two types of anaerobic cycle leg exercise~ force-velocity and 30-s Wingate tests显示文摘 | Souissi N Gauthier A Sesboue B | 2004 | Int J Sports Med2004，25，1： | 1 |
| 8 | Variation in virulence of cereal cyst nematode popula- tions from North Africa and Asia 显示文摘 | MOKABLI A VALETTE S GAUTHIER J P | 2002 | Nematology2002，4，： | 1 |
| 9 | Evaluation of tooth-click triggering and speech recognition in assistive tech- nology for computer access 显示文摘 | Simpson T Gauthier M Prochazka A | 2010 | Neurorehabil Neural Repair2010，24，2： | 1 |
| 10 | Crosslinkable polymers for nanocrystal stabilization显示文摘 | Fuhrmann K Gauthier M A Leroux J C | 2010 | J Contr Rel2010，148，： | 1 |
| 11 | Bioluminescent imaging: applications to cancerology and endocrinology显示文摘 | Pillon A Gauthier P Balaguer P | 2004 | J Soc Biol2004，198，2： | 1 |
| 12 | Effects of Sublethal Doses of Fipronil on the Behavior of the Honeybee (Apis mellifera)显示文摘 | EL HASSANI A K DACHER M GAUTHIER M | 2005 | Pharmacology Biochemistry and Behavior2005，82，： | 1 |
| 13 | Neuroprotective and neurorescuing effect of isoform-specific nitric oxide synthase inhitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity显示文摘 | Law A Gauthier S Quirion R | 2001 | Br J Pharmacol2001，133，： | 1 |
| 14 | Prediction of bone density arotmd orthopedic implants delivering bi- sphosphonate显示文摘 | Stadelmann VA Terrier A Gauthier O | 2009 | J Biomech2009，42，9： | 1 |
| 15 | Adipocyte low density lipoprotein receptor - related protein gene expression and function is regulated by peroxisome proliferator - activated receptor显示文摘 | Gauthier A Vassiliou G Benoist F | 2003 | J Biol Chem2003，278，11： | 1 |
| 16 | Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United Kingdom显示文摘 | Gauthier A Breuer J Carrington D | | 0，，01： | 1 |
| 17 | The effects of donepezil in Alzheimer's disease-results from a multinational trial显示文摘 | Burns A Rossor M Hecker J Gauthier S Petit H M(o)11er H J Rogers SL Friedhoff LT | | 0，，03： | 1 |
| 18 | A group Ⅰ intron in t he chloroplast large subunit rRNA gene of Chlamydomonas eugametos encodes a double-strand endonuclease that cleaves the homing site of this intron显示文摘 | Turmel M Lemieux C | 1991 | Cu rr Genet1991，19，： | 1 |
| 19 | Chemotherapy of advanced small- bowel adenocarcinoma:a multicenter AGEO study显示文摘 | Zaanan A Costes L Gauthier M | 2010 | Ann Oncol2010，21，9： | 1 |
| 20 | Two-dimensional nonlinear in- version of seismic waveforms: numerical results 显示文摘 | Gauthier O Virieux J Tarantola A | 1986 | Geophysics1986，51，7： | 1 |
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