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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Macroprudential capital requirements and systemic risk显示文摘 | Céline Gauthier Alfred Lehar Moez Souissi | 2012 | Journal of Financial Intermediation2012，，4： | 2 |
| 4 | Friedel-Crafts acylation of toluene and p-xylene with carboxylic acids catalyzed by zeolites显示文摘 | Finiels A Gauthier C | 1986 | J Org Chem1986，51，： | 1 |
| 5 | Multiwalled carbon nanotube/polymer nanocomposites:processing and properties显示文摘 | Chazeau L Gauthier C | 2005 | Journal of Polymer Science Part B:Polymer Physics2005，43，10： | 1 |
| 6 | Haemolytic ac tivity,cytotoxicity and membrane cell permeabilization of semi synthetic and natural lupane-and oleanane-type saponins显示文摘 | Gauthier C Legault J Girard-Lalancette IC | 2009 | Bioorg med chem2009，17，5： | 1 |
| 7 | AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance显示文摘 | Gauthier M S Miyoshi H Souza S C | 2008 | J Biol Chem2008，283，24： | 1 |
| 8 | Fractionation of whey' protein hydrolysates using charged UF/NF membranes显示文摘 | Pouliot Y Wijers M C Gauthier S F | 1999 | Journal of Membrane Science1999，158，： | 1 |
| 9 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry 显示文摘 | ZAGHIB K RAVET N GAUTHIER M GENDRON F MAUGER A GOODENOUGH J B JULIEN C M | 2006 | Journal of Power Sources2006，163，： | 1 |
| 10 | Circulating CXCR5~ CD4~ helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production显示文摘 | Zhang X Lindwall E Gauthier C | 2015 | Lupus2015，24，9： | 1 |
| 11 | The mel- anocytorrhagic hypothesis of vitiligo tested on pigmented, stressed, reconstructed epidermis 显示文摘 | CARLO- ANDR_E M PAIN C GAUTHIER Y | 2007 | Pigment Cell Res2007，20，5： | 1 |
| 12 | Optical trapping a tool to assist optical machining显示文摘 | Gauthier R C | 1997 | Optics & Laser Technology1997，9，7： | 1 |
| 13 | Functional beta3-adrenoceptor in the human heart 显示文摘 | Gauthier C Tavernier G Charpentier F | 1996 | J Clin Invest1996，98，2： | 1 |
| 14 | Crosslinkable polymers for nanocrystal stabilization显示文摘 | Fuhrmann K Gauthier M A Leroux J C | 2010 | J Contr Rel2010，148，： | 1 |
| 15 | Optical trapping a tool to assist optical machining显示文摘 | GAUTHIER R C | 1997 | Optics & Laser Technology1997，9，7： | 1 |
| 16 | Electron magnetic resonance and optical properties of Ga2(1-x) In2p 03 solid solutions 显示文摘 | Binet L Gauthier G Vigreux C Gourier D | 1999 | Journal of Physics and Chemistry of Solids1999，60，10： | 1 |
| 17 | Reactive surfactants in heterophase polymerization (XVI) : Emulsion copolymerization of styrene-butyl acrylate-acrylic acid in the presence of simple maleate reactive surfaetants显示文摘 | SINDT O GAUTHIER C HAMAIDE T | 2000 | Journal of Applied Polymer Science2000，77，12： | 1 |
| 18 | Inthencce of SiO2 fillers on the irradiation ageing of silicone rubbers 显示文摘 | Stevenson I David L Gauthier C | 2004 | Polymer2004，42，22： | 1 |
| 19 | ACE inhibi-tion enhances bradykinin relaxations through nitric oxideand B1 receptor activation in bovinecoronary arteries 显示文摘 | Gauthier K M Cepura C J Campbell W B | 2013 | Biol Chem2013，394，9： | 1 |
| 20 | Long-term monitoring at multiple trophic levels suggests heterogeneity in responses to climate change in the Canadian Arctic tundra显示文摘 | GAUTHIER G BETY J CADIEUX M C | 2013 | Philosophical Transactions of the Royal Society B:Biological Sciences2013，368，20： | 1 |
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