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| 1 | Research Progress on the Relationship between Coronary Artery Calcification and Chronic Renal Failure显示文摘 | Jun Lai Gael Akindavyi Qiang Fu Zhi-Liang Li Hui-Min Wang Li-Hua Wen | 2018 | Chinese Medical Journal2018，，5： | 18 |
| 2 | 真武汤可延缓尿毒症心肌病大鼠心室肥厚显示文摘目的探讨真武汤对尿毒症心肌病大鼠心室肥厚的作用及可能机制。方法(1)提取SD乳鼠心肌细胞,将其分为对照组及硫酸吲哚酚(indoxyl sulfate, IS)组(10μm刺激),通过[3H]亮氨酸掺入法、Western blot(WB)检测两组细胞蛋白表达情况;(2)将50只SD大鼠随机分成假手术组、模型组、真武汤低(4.5 g/kg)、高剂量干预组(13.5 g/kg),除假手术组外,其他各组均予5/6肾切除术。术后4周,低剂量组及高剂量组分别每天给与真武汤灌胃,假手术组和模型组给予等量蒸馏水灌胃。给药4周后,检测各组大鼠血生化、血浆硫酸吲哚酚水平(IS),心脏及心室重量指数、心脏彩超、心肌组织BNP、p-ERK1/2、p-p38及p-JNK蛋白表达等情况。结果(1)细胞实验中,IS组心肌细胞蛋白质合成速率明显增加,而BNP、p-ERK1/2、p-p38表达均较对照组升高(均P<0.01),而P-JNK蛋白则与对照组相比未见明显差异;(2)与假手术组相比,模型组的血肌酐(SCr)、尿素氮(BUN)、24小时尿蛋白(24hUpro)、IS及左室质量指数(LVMI)、全心质量指数(HMI)均升高(P<0.01);左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)均有显著降低,左心室前壁收缩末期厚度(LVAWS)、左心室前壁舒张末期厚度(LVAWD)、左心室后壁收缩期厚度(LVPWS)、左心室后壁舒张期厚度(LVPWD)则明显增厚;HE染色示心肌细胞肥大。心肌组织蛋白BNP、p-ERK1/2、p-p38、p-jnk的表达均升高(P<0.01);(3)低剂量和高剂量组SCr、BUN、24 hUpro及IS较模型组降低(P<0.05),LVMI及HMI在低剂量、高剂量组中下降;LVESD、LVEDD、LVPWS、LVAWS、LVAWD等在高剂量组中改善较为显著,心肌组织蛋白BNP、p-ERK1/2、pp38及p-JNK的表达下调。结论真武汤可降低尿毒症心肌病大鼠血浆IS水平,进而延缓IS对心肌肥厚作用,延缓心室重构。 | 赖俊 吴英智 杭丽玮 Gael Akindavyi 邓婷 严全能 傅强 李志樑 | 2019 | 南方医科大学学报2019，39，1： | 8 |
| 3 | 炎症小体Nlrp3通路激活在尿毒症心肌病模型小鼠左心室重构的作用显示文摘目的探讨Nlrp3炎症小体通路激活与尿毒症心肌病小鼠左心室重构的关系及可能机制。方法将20只小鼠随机分为假手术组和模型组。模型组予5/6肾脏切除术。两组小鼠术后第8周行心脏超声检查,检测血肌酐(Scr)、血尿素氮(BUN)、血浆硫酸吲哚酚(indoxyl sulfate,IS)水平,心肌组织ANP、BNP、Nlrp3、Pro-caspase1、IL-1β和p-P65蛋白表达。培养小鼠巨噬细胞RAW264.7,分为对照组及IS组,检测两组细胞Nlrp3、Pro-caspase1和IL-1β蛋白表达。结果与假手术组相比,模型组小鼠Scr、BUN和IS水平均升高(P<0.05);左心室前壁舒张末期厚度(LVAWd)和左心室后壁舒张末期厚度(LVPWd)增厚,射血分数(EF)和短轴缩短率(FS)降低。更进一步,左心室等容舒张时间和E/A上升,LVFS/MPI下降。HE染色可见心肌细胞肥大。模型组心肌组织ANP、BNP、Nlrp3、Pro-caspase1、IL-1β和p-P65蛋白表达均上调。IS刺激小鼠巨噬细胞Nlrp3、Pro-caspase1和IL-1β蛋白表达均上调。以上结果均具有统计学意义。结论尿毒症心肌病小鼠左心室肥厚与血浆IS水平上调密切相关,可能与NF-κB信号通路激活炎症小体Nlrp3高度相关。 | 文俪桦 傅强 严全能 李晚泉 贺不凡 Gael Akindavyi 李志樑 | 2020 | 实用医学杂志2020，36，9： | 4 |
| 4 | 4例顽固性室性心动过速患者行ECMO+心外膜射频消融的术中护理显示文摘目的总结4例顽固性室性心动过速患者在静脉-动脉体外肺膜氧合(VA-ECMO)辅助下行心包穿刺心外膜射频消融术的术中护理经验。方法4例患者在心血管内科、ICU、麻醉科、介入手术室、护理等多学科团队协作下,术前制定周密的手术方案、应急预案和具体分工,由多学科团队联合提供手术全程监护,术中护理重点包括:注重术中的低体温、出血、溶血及灌注量变化、管道的管理、并发症的预防等问题,严密观察病情和配合手术,加强生命体征监测和出凝血监测,进行管道和穿刺口安全管理。结果4例患者手术成功,术中未发生严重并发症,住院时间为(12.50±2.06)d。1例在术后当天出现心源性休克,及时以CRRT配合治疗后好转出院。结论VA-ECMO能在术中提供血流动力学支持,提高手术成功率。术中护士与团队紧密配合,加强术中体温、出血/溶血、灌注量的监护,实施并发症的预见护理,可为手术提供安全保障。 | 王玉珊 陈健聪 付晓华 冷坷 何维娟 Akindavyi Gael | 2020 | 护理学报2020，27，7： | 4 |
| 5 | Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma显示文摘BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE)is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE)in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with Child-Pugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the mRECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93%and 87%of cirrhotic patients and 87%and 70%of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31%and 26%of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7%and 73.3%(P=0.797)with 41.7%and 40.0%complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35%of Dox-TACE and 43%of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC. | Gael Stephane Roth Yann Teyssier Melodie Abousalihac Arnaud Seigneurin Julien Ghelfi Christian Sengel Thomas Decaens | 2020 | World Journal of Gastroenterology2020，26，3： | 3 |
| 6 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 7 | Association between early viral lower respiratory tract infections and subsequent asthma development显示文摘BACKGROUND The association between hospitalization for human respiratory syncytial virus(HRSV)bronchiolitis in early childhood and subsequent asthma is well established.The long-term prognosis for non-bronchiolitis lower respiratory tract infections(LRTI)caused by viruses different from HRSV and rhinovirus,on the other hand,has received less interest.AIM To investigate the relationship between infant LRTI and later asthma and examine the influence of confounding factors.METHODS The PubMed and Global Index Medicus bibliographic databases were used to search for articles published up to October 2021 for this systematic review.We included cohort studies comparing the incidence of asthma between patients with and without LRTI at≤2 years regardless of the virus responsible.The meta-analysis was performed using the random effects model.Sources of heterogeneity were assessed by stratified analyses.RESULTS This review included 15 articles(18 unique studies)that met the inclusion criteria.LRTIs at≤2 years were associated with an increased risk of subsequent asthma up to 20 years[odds ratio(OR)=5.0,95%CI:3.3-7.5],with doctor-diagnosed asthma(OR=5.3,95%CI:3.3-8.6),current asthma(OR=5.4,95%CI:2.7-10.6),and current medication for asthma(OR=1.2,95%CI:0.7-3.9).Our overall estimates were not affected by publication bias(P=0.671),but there was significant heterogeneity[I 2=58.8%(30.6-75.5)].Compared to studies with hospitalized controls without LRTI,those with ambulatory controls had a significantly higher strength of association between LRTIs and subsequent asthma.The strength of the association between LRTIs and later asthma varied significantly by country and age at the time of the interview.The sensitivity analyses including only studies with similar proportions of confounding factors(gender,age at LRTI development,age at interview,gestational age,birth weight,weight,height,smoking exposure,crowding,family history of atopy,and family history of asthma)between cases and controls did not alter the overall estimates.CONCLUSION Regardless of the causative virus and confounding factors,viral LRTIs in children<2 years are associated with an increased risk of developing a subsequent asthma.Parents and pediatricians should be informed of this risk. | Sebastien Kenmoe Etienne Atenguena Okobalemba Guy Roussel Takuissu Jean Thierry Ebogo-Belobo Martin Gael Oyono Jeannette Nina Magoudjou-Pekam Ginette Irma Kame-Ngasse Jean Bosco Taya-Fokou Chris Andre Mbongue Mikangue Raoul Kenfack-Momo Donatien Serge Mbaga Arnol Bowo-Ngandji Cyprien Kengne-Ndé Seraphine Nkie Esemu Richard Njouom Lucy Ndip | 2022 | World Journal of Critical Care Medicine2022，11，4： | 3 |
| 8 | Epidemiological investigation of infectious hematopoietic necrosis virus in salt water net-pen reared Atlantic salmon in British Columbia, Canada显示文摘 | Sophie St-Hilaire Carl S Ribble Craig Stephen Eric Anderson Gael Kurath Michael L Kent | 2002 | Aquaculture2002，，1： | 2 |
| 9 | Ultrahigh- resolution full-field optical coherence tomography显示文摘 | Arnaud Dubois Kate Grieve Gael Moneron | 2004 | APPLIED OPTICS2004，43，14： | 1 |
| 10 | Hypotheses refinement under topological communication constraints显示文摘 | Gauvain Bourgne Gael Hette Nicolas Maudet | 2007 | International Conference on Autonomous Agents2007，6，2： | 1 |
| 11 | Algebraic point set surfaces显示文摘 | Guennebaud Gael Gross | 2007 | ACM Transactions on Graphics2007，26，3： | 1 |
| 12 | Computed tomographies and cancer risk in children: a literature overview of CT practices, risk estimations and an epidemiologic cohort study proposal显示文摘 | Lucian Krille Hajo Zeeb Andreas Jahnen Peter Mildenberger Michael Seidenbusch Karl Schneider Gerald Weisser Gael Hammer Peter Scholz Maria Blettner | 2012 | Radiation and Environmental Biophysics2012，，2： | 1 |
| 13 | Efficacy and safety of recruitment maneuvers in acute respiratory distress syndrome显示文摘 | Claude Guerin Sophie Debord Véronique Leray Bertrand Delannoy Frédérique Bayle Gael Bourdin Jean-Christophe Richard | 2011 | Annals of Intensive Care2011，，1： | 1 |
| 14 | Modeling and characterization of piezoelectric fibers with metal core 显示文摘 | Gael S Qiu J Daniel G | 2005 | Japanese Journal of Applied Physics2005，44，8： | 1 |
| 15 | The 14 -bp deletion- insertion polymorphism in the 3 UT region of the HLA - G gene influences HLA - G mRNA stability 显示文摘 | Philippe R Magali LD Gael M | 2003 | Hum Immunol2003，64，11： | 1 |
| 16 | Solid-phase submonomer synthesis of peptoid polymers and their self-assembly into highly- ordered nanosheets显示文摘 | Tran H Gael S L Connolly M D | 2011 | Journal of visualized experiments: JOVE2011，，57： | 1 |
| 17 | Modelling the lateral resonance mode of piezoelectric fibers with metal core显示文摘 | Gael S Qiu J Daniel G | 2005 | Journal of Physics D: Applied Physics2005，，38： | 1 |
| 18 | Relationship marketing and innovation:the case of the launch of Wireless Local Loop telecommunication services in France显示文摘 | Gael Bonnin Olivier Segard Pierre Vialle | 2005 | Journal of Services Research Special Issue (December2005，2005，： | 1 |
| 19 | Effective- ness of Multilayer Viscoelastic Insulators to Prevent Occurrences of Brake Squeal: A Numerical Study显示文摘 | FESTJENS H GAEL C FRANCK R | 2012 | Applied Acoustics2012，73，11： | 1 |
| 20 | Acoustic radiation force impulse: a new ultrasonographic technology for the widespread noninvasive diagnosis of liver fibrosis显示文摘 | Jér?me Boursier Gael Isselin Isabelle Fouchard-Hubert Frédéric Oberti Nina Dib Jér?me Lebigot Sandrine Bertrais Yves Gallois Paul Calès Christophe Aubé | 2010 | European Journal of Gastroenterology & Hepatology2010，，9： | 1 |
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