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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | 核碎裂的标度特性显示文摘在一定的条件下,例如通过中高能重离子碰撞,原子核会碎裂成许多轻的核碎片。这种新的反应机制称为核碎裂。同发生临界现象时的宏观系统相类似,核碎裂也显示出标度特性。但这一特性只能部分地被重组聚集模型(RAM)所描述。本文给出了推广的重组聚集模型,并用它很好地复制了乳胶实验测得的核碎裂的标度特性。计算结果表明,当核内沉积的能量约为它束缚能的80—90%(≈6MeV)时,这一临界现象就出现了。 | 郑玉明 H. N■■Division C. N■■ S. Leray | 1990 | 科学通报1990，35，22： | 2 |
| 3 | Sur le mouvement d’un liquide visqueux emplissant l’espace显示文摘 | Jean Leray | 1934 | Acta Mathematica1934，，1： | 1 |
| 4 | Sur le mouvement dun liquide visqueux emplissant lespace显示文摘 | LERAY J | 1934 | Acta Math1934，63，： | 1 |
| 5 | A highly sensitive and selectivefluorescent molecular sensor for Pb(II)based on a calixarenebearing four dansyl groups显示文摘 | Métivier R Leray I Valeur B | 2003 | Chem Commun2003，37，： | 1 |
| 6 | Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience 显示文摘 | Patard JJ Leray E Rioux-Leclercq N | 2005 | J Clin Oncol2005，23，12： | 1 |
| 7 | Biological markers in hepatocellular carcinoma 显示文摘 | Deugnier Y David V Leray G | 1988 | Ann Biol Clin1988，46，1： | 1 |
| 8 | Prevalence,characteristics and comorbidities of anxiety disorders in France:results from the 'Men-tal Health in General Population' survey(MHGP)显示文摘 | Leray E Camara A Drapier D | 2010 | European Psychiatry2010，26，6： | 1 |
| 9 | Sur le mouvement d'un liquide visqueux emplissant Fespace显示文摘 | Leray J | 1934 | Acta Mathematica1934，，63： | 1 |
| 10 | Etudes de diverses &tuationsint6grales non lin6aires et de quelquesprobl6mes que pose l'hydrodynamique 显示文摘 | LERAY J | 1933 | J Math Pures Appl1933，12，： | 1 |
| 11 | Mitoxantrone as induction treatment in aggressive relapsing remitting multiple sclerosis:treatment response factors in a 5 year follow-up observational study of 100 consecutive patients显示文摘 | Le Page E Leray E Taurin G | | 0，，01： | 1 |
| 12 | A study of radiation vulnerability of ferroelectric material and devices显示文摘 | COLC Y M MUSSEAU O LERAY J L | 1994 | IEEE Trans Nucl Sci1994，41，3： | 1 |
| 13 | Bolted Joints for Very Large Bearings-Numerical Model Development 显示文摘 | Vadean A Leray D Guillot J | 2006 | Finite Elements in Analysis and Design2006，，42： | 1 |
| 14 | Prognostic value of histologic subtypes in renal cell carcinoma:A multicenter experience显示文摘 | PATARD JJ LERAY E RIOUX-LECLERCQ N | 2005 | J Clin Oncol2005，23，： | 1 |
| 15 | Sur le mouvement d’un liquide visqueux emplissant l’espace显示文摘 | Jean Leray | 1934 | Acta Mathematica1934，，1： | 1 |
| 16 | Efficacy and safety of recruitment maneuvers in acute respiratory distress syndrome显示文摘 | Claude Guerin Sophie Debord Véronique Leray Bertrand Delannoy Frédérique Bayle Gael Bourdin Jean-Christophe Richard | 2011 | Annals of Intensive Care2011，，1： | 1 |
| 17 | Efficacy and safety of recruitment maneuvers in acute respiratory distress syndrome 显示文摘 | Claude Guerin Sophie Debord Verenique Leray | 2011 | An- rials of Intensive Care2011，32，1： | 1 |
| 18 | Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis显示文摘 | Leray MD | 1999 | Thrombosis Res1999，93，1： | 1 |
| 19 | Stereo-regular bioresorbable polyesters for orthopaedie surgery显示文摘 | Vert M Chabot F Leray J | 1981 | Makromol Chem1981，，5： | 1 |
| 20 | CMOS/SOI Hardening at 100Mrad(SiO2) 显示文摘 | Leray J L Dupont - Nivet E Pere J L | 1990 | IEEE Trans Nucl Sci1990，37，6： | 1 |
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