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1Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt显示文摘BACKGROUND Segmental intrahepatic cholestasis caused by transjugular intrahepatic portosystemic shunt(TIPS)(SIC-T),is a rare complication of this technique and only referred by case reports.Thus,we conducted a systematic,retrospective analysis to provide evidence regarding prevalence and consequences of this TIPS-induced bile duct compression.AIM To assess prevalence and outcome of SIC-T in a large TIPS-cohort.METHODS In this retrospective cohort study,we screened the institutional databases for all consecutive patients that were treated by TIPS-placement or TIPS-revision between January 2005 and August 2013.We analyzed radiologic images for signs of biliary congestion.Cases that were indicative of SIC-T were reviewed by two independent radiologists and additional patient data was collected.Descriptive statistics of patient demographics,indications for TIPS and procedural details were registered.Logistic regression analysis was performed to identify predictors for the development of SIC-T.RESULTS We analyzed 135 cirrhotic patients who underwent TIPS(mean age 55 years,79%male gender).Etiology of cirrhosis was alcohol in most cases and indications for TIPS were mainly refractory ascites and recurrent variceal bleeding.TIPS revision was necessary in 31 patients.We identified 4 cases(2.9%)of SIC-T in direct proximity of the TIPS-stent.Diagnosis was confirmed by CT-scan,MRI or endoscopic retrograde cholangio pancreaticography(ERCP).In two patients TIPS was implanted via the right and in one through the medial hepatic vein.One patient received TIPS-prolongation by multiple revisions.Most patients were asymptomatic but one cholangitic abscess necessitated a transhepatic drain.Logistic regression analysis identified TIPS-placement other than from medial hepatic vein to right portal vein as risk factor(OR 21.0)for SIC-T.CONCLUSION SIC-T ads to(mostly late)complications in the interventional treatment of cirrhotic portal hypertensions and can lead to cholangitic abscesses.Patients,particularly with multiple interventions,should be screened for SIC-T.Julian Nikolaus Bucher Marcus Hollenbach Steffen Strocka Gereon Gaebelein Michael Moche Thorsten Kaiser Michael Bartels Albrecht Hoffmeister 2019World Journal of Gastroenterology2019,25,43:2
2Effect of an individual readiness assurance test on a team readiness assurance test in the team-based learning of physiology 显示文摘Gopalan C Fox D J Gaebelein CJ 2013Adv Physiol Educ2013,37,1:1
3Effect of an individual readiness assurance test on a team readiness assurance test in the team-based learning of physiology显示文摘Gopalan C Fox DJ Gaebelein CJ 2013Adv Physiol Educ2013,37,1:1
4Impact of microvessel density on lymph node metastasis and survival after curative resection of pancreatic cancer显示文摘Christoph Benckert Armin Thelen Thorsten Cramer Wilko Weichert Gereon Gaebelein Reinhard Gessner Sven Jonas 2012Surgery Today2012,,2:1
5The relationship among heart rate, carotid dP/dt, and blood pressure in humans as a function of the type of stress 显示文摘OBRIST P A GAEBELEIN C J TELLER E S 1978Psychophysiology1978,15,2:1
6Transplantation of Monocyte-Derived Hepatocyte-Like Cells (NeoHeps) Improves Survival in a Model of Acute Liver Failure显示文摘Matthias Glanemann Gereon Gaebelein Natascha Nussler Liping Hao Zienab Kronbach Baomin Shi Peter Neuhaus Andreas K. Nussler 2009Annals of Surgery2009,,1:1
7Balanced management of hepatic trauma is associated with low liver - related mortality 显示文摘BENCKERT C THELEN A GAEBELEIN G 2010Arch Surg2010,395,4:1
8Balanced management of hepatic trauma is associated with low liver-related mortality 显示文摘Benckert C Thelen A Gaebelein G 2010Langenbecks Arch Surg2010,395,4:1
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