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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity 显示文摘 | MARIA L P GABRIELE D L PASQUALE M | 2006 | Mediators Inflamm2006，，62： | 1 |
| 3 | Longterm outcome of pa- tiens with ventricular septal defect considered not to require surgical cloure during childhood显示文摘 | Gabriel HM Heger M Innerhofer P | 2002 | J Am Coil Cardiol2002，39，： | 1 |
| 4 | Induction chemotherapywith carboplatin and taxol followed by radiotherapy and concurrentweekly carboplatin + taxol in locally advanced nasopharyngeal carci-noma 显示文摘 | Airoldi M Gabriele P Gabriele AM | 2011 | Cancer Chemother Pharmacol2011，67，5： | 1 |
| 5 | Comparing effects of three acaricides on Varroa jacobsoni (Acari:Varmidae) and Apis melifera (Hymenoptera:Apidac) using two application techniques显示文摘 | Santigo G P Gabriel O C David M S | 2000 | Florida Entomo-logy2000，83，4： | 1 |
| 6 | Family based association study of 76 candidate genes in bipolar disorder:BDNF is a poten-tial risk locus显示文摘 | Sklar P Gabriel S B McInnis M G | | 0，，06： | 1 |
| 7 | Development and evaluation of a CERES-type model for winter oilseed rape显示文摘 | Gabrielle B Denoroy P Gosse G Justes E Andersen M N | 1998 | Field Crops Research1998，57，： | 1 |
| 8 | Degradation of coal by the Fungi Polyporous Versicol or and Poria Placenta 显示文摘 | Cohen M S Gabriele P D | 1982 | Applied and Environmental Microbial1982，44，1： | 1 |
| 9 | Superparamagnetic Iron Oxide Contrast Agents:Physicochemical Characteristics and Application in MR Imaging显示文摘 | Yi-Xiang J Wang Shahid M Hussain Gabriel P | 2001 | Eur Radiol2001，11，11： | 1 |
| 10 | Micromachined devices for wireless communications 显示文摘 | Clark T - C Nguyen Linda P B Katehi Gabriel M Rebeiz | 1998 | Proceeding fo the IEEE1998，86，8： | 1 |
| 11 | Impact of Imbalancing in the Self-splitting of Beams with Nested Vortices into Solitons in Quadratic Non-linear Crystals显示文摘 | Gabriel Molina-Terriza Juan P Torres Lluis Torner Soto-Crespo J M | 1998 | Optics Communications1998，158，： | 1 |
| 12 | Quality of orange juice drink subjected to a predictive model-based pasteurization process 显示文摘 | GABRIEL A A AZANZA M P V | 2009 | Journal of Food Quality2009，32，4： | 1 |
| 13 | Corrosion behaviour of magnesium sacrificial anodes in tap water显示文摘 | ANDREI M GABRIELE F D BONORA P L | 2003 | Materials and Corrosion2003，54，5： | 1 |
| 14 | Hyperthermia and radiation therapy for inoperable or recurrent parotid carcinoma显示文摘 | Gabriele P Amichetti M Orecchia R | 1995 | Cancer1995，75，4： | 1 |
| 15 | The life history and consumption habits of Cyrtorhinus lividipennis Reuter (Hemiptera:Miridae)显示文摘 | Reyes T M Gabriel B P | 1975 | Philipp Entomol1975，，3： | 1 |
| 16 | Ejaculatoryduct calculus causing secondary obstruction and infertility 显示文摘 | JOE P RAMASWAMY M GABRIEL HR | 2007 | Fertil Steril2007，88，3： | 1 |
| 17 | The influence of layered compounds on the properties of starch/layered compound composites 显示文摘 | Helena - M Wilhelm Maria - R Sierakowski Gabriel P Souza | 2003 | Polymer International2003，52，： | 1 |
| 18 | Chemopre- ventive potential of 13-Sitosterol in experimental colon cancer model-an in vitro and in vivo study 显示文摘 | Albert A B Savarimuthu I Gabriel M P | 2010 | BMC Complement Al- tern Med2010，10，： | 1 |
| 19 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 20 | Degradation of Coal by the Fungi Polyporous Versicolor and Poria Placenta显示文摘 | Cohen M S Gabriele P D | 1982 | Appied and Environmental Microbial1982，44，1： | 1 |
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