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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Interferon-γ: Promising therapeutic target in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disorder of the vasculature and is the primary cause of cardiovascular disease(CVD). CVD is currently the world's leading cause of death and the numbers are predicted to rise further because of a global increase in risk factors such as diabetes and obesity. Current therapies such as statins have had a major impact in reducing mortality from CVD. However, there is a marked residual CVD risk in patients on statin therapy. It is therefore important to understand the molecular basis of this disease in detail and to develop alternative novel therapeutics. Interferon-γ(IFN-γ) is a pro-inflammatory cytokine that is often regarded as a master regulator of atherosclerosis development. IFN-γ is able to influence several key steps during atherosclerosis development, including pro-inflammatory gene expression, the recruitment of monocytes from the blood to the activated arterial endothelium and plaque stability. This central role of IFN-γ makes it a promising therapeutic target. The purpose of this editorial is to describe the key role IFN-γ plays during atherosclerosis development, as well as discuss potential strategies to target it therapeutically. | Joe WE Moss Dipak P Ramji | 2015 | World Journal of Experimental Medicine2015，5，3： | 7 |
| 3 | 慢性阻塞性肺疾病知识(一) 诊断显示文摘和其他常见的疾病一样,慢性阻塞性肺疾病(COPD)的诊断依靠相关病史和适当的检查。确诊的客观证据依靠呼吸功能测量。对于35岁以上,有吸烟史及相关呼吸道症状的患者,医生应考虑到COPD的可能。 | Graeme P Currie Joe S Legge 陈奇 | 2007 | 英国医学杂志中文版2007，10，1： | 3 |
| 4 | Development of macro porosity inac- tivated carbons by effect of coal preoxidation and bum-off显示文摘 | Joes J P JOS B PARRA | 1998 | Fu- el1998，77，6： | 1 |
| 5 | The need for surveillance in intelligent transportation systems显示文摘 | Joe P | 1997 | Intellimotion1997，6，1： | 1 |
| 6 | Ejaculatoryduct calculus causing secondary obstruction and infertility 显示文摘 | JOE P RAMASWAMY M GABRIEL HR | 2007 | Fertil Steril2007，88，3： | 1 |
| 7 | Weather services, science advances, and the Vancouver 2010 Olympic and Paralympic Winter Games显示文摘 | Joe P Doyle C Wallace A | 2010 | Bulletin of the American Meteorological Society2010，91，1： | 1 |
| 8 | Addition of tea catechins and vitamin C on sensory evaluation, colour and lipid stability during chilled storage in cooked or raw beef and chicken patties 显示文摘 | Mitsuru Mitsumoto Michael N OGrady Joe P Kerry | 2005 | Meat Science2005，69，4： | 1 |
| 9 | Metal oxide thin film based supercapaeitors显示文摘 | Lokhande C D Dubal D P Joe 0 S | 2011 | Current Applied Physics2011，11，： | 1 |
| 10 | Pharmacological interventions for spinal cord injury:Where do we stand? How might we step forward显示文摘 | Alexander G Rabchevsky Samir P Patel Joe E Springer | | 0，，01： | 1 |
| 11 | Non-bonded interactions and its contribution to the NLO activity of glycine sodium Nitrate-A vi- brational approach 显示文摘 | Vijayakumar T Joe I H Nair C P R | 2008 | Journal of Molecular Structure2008，877，： | 1 |
| 12 | Learning Online Community Citizenship Behavior: A Socio-Cognitive Model显示文摘 | JOE S W LIN C P | 2008 | CyberPsychology & Behavior2008，11，3： | 1 |
| 13 | High-resolution magnetic mapping of contaminated sediments in urbanized environments 显示文摘 | JOE B MATT P BILL M | 2001 | The Leading Edge August2001，，： | 1 |
| 14 | Minority group status and treatment retention 显示文摘 | Brown BS Joe GW Thompson P | 1985 | Int J Addict1985，20，2： | 1 |
| 15 | Comparison of raindrop size distributionmeasurements by a Joss-Waldvogel Disdrometer,a PMS 2DGSpectrometer,and a POSS Doppler Radar显示文摘 | Sheppard B ? Joe P I | 1994 | Journal of Atmos-pheric and Oceanic Technology1994，11，： | 1 |
| 16 | The Sydney 2000 World Weather Research Programme Forecast Demonstration Project:Overview and current status 显示文摘 | Keenan T J Wilson P Joe | 2003 | Bull Amer Meteor Soc2003，84，： | 1 |
| 17 | Radiation-induced bystander signalling in cancer therapy 显示文摘 | Kevin M P Joe M O | 2009 | Nature Reviews Cancer2009，9，5： | 1 |
| 18 | Adoptive immunotherapy of cancer using ex vivo expanded human gammadeha T cells : A new approach显示文摘 | Dokouhaki P Han M Joe B | 2010 | Cancer Lett2010，297，1： | 1 |
| 19 | Vocabulary Learning and Speaking Activities显示文摘 | Joe A Nation P Newton J | 1996 | English Teaching Forum1996，37，1： | 1 |
| 20 | Absolute Calibration of a Geodetic Time Transfer System 显示文摘 | JOHN P KRISTINE M L JOE W | 2005 | IEEE transactions on ultrasonics ferroelectrics and fre- quency control2005，52，11： | 1 |
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