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| 1 | Immunity Genes and Susceptibility to Otitis Media:A Comprehensive Review显示文摘Otitis media(OM) is a middle ear infection associated with inflammation and pain.This disease frequently afflicts humans and is the major cause of hearing loss worldwide.OM continues to be one of the most challenging diseases in the medical field due to its diverse host targets and wide range of clinical manifestations.Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media(CSOM).Children have greater susceptibility to,and thus,suffer most frequently from OM,which can cause significant deterioration in quality of life.Genetic factors have been demonstrated,in large part by twin and family studies,to be key determinants of OM susceptibility.In this review,we summarize the current knowledge on immunity genes and selected variants that have been associated with predisposition to OM.In particular,polymorphisms in innate immunity and cytokine genes have been strongly linked with the risk of developing OM.Future studies employing state-of-the-art technologies,including next-generation sequencing(NGS),will aid in the identification of novel genes associated with susceptibility to OM.This,in turn,will open up avenues for identifying high-risk individuals and designing novel therapeutic strategies based on precise targeting of these genes. | Rahul Mittal Giannina Robalino Robert Gerring Brandon Chan Denise Yan M'hamed Grati Xue-Zhong Liu | 2014 | Journal of Genetics and Genomics2014，41，11： | 5 |
| 2 | The genome of eucalyptus grandis显示文摘 | MYBURG A A GRATI'A D TUSKAN G A | 2014 | Nature2014，510，： | 1 |
| 3 | Regulation of stereocilialength by myosin XVa and whirlin depends on the actin-regula-tory protein Eps8显示文摘 | Manor U Disanza A Grati M | 2011 | Curr Biol2011，21，2： | 1 |
| 4 | Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction显示文摘 | Silvia Tabano Patrizia Colapietro Irene Cetin Francesca R. Grati Susanna Zanutto Chiara Mandò Patrizio Antonazzo Paola Pileri Franca Rossella Lidia Larizza Silvia M. Sirchia Monica Miozzo | 2010 | Epigenetics2010，，4： | 1 |
| 5 | SI-IOX duplications found in some cases with type I Mayer-Rokitansky-Kuster-Hauser syn- drome显示文摘 | Gervasini C Grati FR Lalatta F | 2010 | Genet Med2010，12，10： | 1 |
| 6 | OTOF en-codes multiple long and short isoforms:genetic evidencethat the long ones underlie recessive deafness DFNB9显示文摘 | Yasunaga S Grati M Chardenoux S | 2000 | Am J Hum Genet2000，67，3： | 1 |
| 7 | Compared effects of etomid- ate and propofol for anaesthesia during electroconvulsive therapy 显示文摘 | Grati L Louzi M Nasr K | 2005 | Presse Med2005，34，： | 1 |
| 8 | A mutation in OTOF,encoding otoferlin,a FER-1-like protein,causes DFNB9,a nonsyndromic form of deafness显示文摘 | Yasunaga S Grati M Cohen-Salmon M | 1999 | Nat Genet1999，21，4： | 1 |
| 9 | A mutation a FER- l-like protein, causes DFNBg, a nonsyndromic form of deafness显示文摘 | Yasunaga S Grati M Cohen in OTOF encoding otoferlin -Salmon M | 1999 | Nat Gen et1999，21，： | 1 |
| 10 | Another approach to linear shell theory and a new proof of Korn's inequality on a surface显示文摘 | Ciarlet P G Gratie L | 2005 | C R Acad Sci Paris: Ⅰ2005，340，： | 1 |
| 11 | OTOF encodes multiple long and short isoforms:genetic evidence that the long ones underlie recessive deafness DFNB9显示文摘 | Yasunaga S Grati M Chardenoux S | 2000 | Am J Hum Genet2000，67，3： | 1 |
| 12 | A new approach to linear shell theory显示文摘 | Ciarlet P G Gratie L | 2005 | Math Models Methods Appl Sci2005，15，8： | 1 |
| 13 | Molecular deter minants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells显示文摘 | Grati M Aggarwal N Strehler EE | 2006 | J Cell Sci2006，119，： | 1 |
| 14 | Optimisation of olive oil extraction and minor compounds content of Tunisian olive oil using enzymatic formulations during malaxation显示文摘 | Hadj-Taieb N Grati N | 2012 | Biochemical Engineering Journal2012，62，3： | 1 |
| 15 | Chromosome abnormalities investigated by non-invasive prenatal testing account for approximately 50% of fetal unbalances associated with relevant clinical phenotypes显示文摘 | Grati FR Barlocco A Grimi B | 2010 | Am J Med Genet2010，152，6： | 1 |
| 16 | The applica- tion of genome editing in studying hearing loss显示文摘 | ZOU B MH'TAL R GRATI M | 2015 | Hear Res2015，327，： | 1 |
| 17 | Otoferlin,defective in a human deaf-ness form,is essential for exocytosis at the auditory ribbon syn-apse显示文摘 | Roux I Safieddine S Nouvian R Grati M Simmler M-C Bahloul A Perfettini I Le Gall M Rostaing P Hamard G Triller A Avan P Moser T Petit C | | 0，，： | 1 |
| 18 | Compared effects of etomidate and propofol for anaesthesia during electroeonvulsive therapy显示文摘 | Grati L Louzi M Nasr K | 2005 | Presse Med2005，34，4： | 1 |
| 19 | A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness显示文摘 | Yasunaga S Grati M Petit C | 1999 | Nature Genet1999，21，： | 1 |
| 20 | OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9 显示文摘 | Yasunaga S Grati M Petit C | 2000 | Am J Hum Genet2000，67，： | 1 |
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