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| 1 | Bilirubin in coronary artery disease:Cytotoxic or protective?显示文摘Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established. | Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 14 |
| 2 | Immunity Genes and Susceptibility to Otitis Media:A Comprehensive Review显示文摘Otitis media(OM) is a middle ear infection associated with inflammation and pain.This disease frequently afflicts humans and is the major cause of hearing loss worldwide.OM continues to be one of the most challenging diseases in the medical field due to its diverse host targets and wide range of clinical manifestations.Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media(CSOM).Children have greater susceptibility to,and thus,suffer most frequently from OM,which can cause significant deterioration in quality of life.Genetic factors have been demonstrated,in large part by twin and family studies,to be key determinants of OM susceptibility.In this review,we summarize the current knowledge on immunity genes and selected variants that have been associated with predisposition to OM.In particular,polymorphisms in innate immunity and cytokine genes have been strongly linked with the risk of developing OM.Future studies employing state-of-the-art technologies,including next-generation sequencing(NGS),will aid in the identification of novel genes associated with susceptibility to OM.This,in turn,will open up avenues for identifying high-risk individuals and designing novel therapeutic strategies based on precise targeting of these genes. | Rahul Mittal Giannina Robalino Robert Gerring Brandon Chan Denise Yan M'hamed Grati Xue-Zhong Liu | 2014 | Journal of Genetics and Genomics2014，41，11： | 5 |
| 3 | An adaptive fuzzy thresholding algorithm for exon prediction显示文摘 | Ankit Agrawal Ankush Mittal Rahul Jain Raghav Takkar | 2008 | IEEE ICCCET2008，，： | 1 |
| 4 | Molecular typing of canine parvovirus strains circulating from 2008 to 2012 in an organized kennel in India reveals the possibility of vaccination failure显示文摘 | Mitesh Mittal Soumendu Chakravarti J.K. Mohapatra P.K. Chug Rahul Dubey P.S. Narwal Anil Kumar C.P. Churamani N.S. Kanwar | 2014 | Infection, Genetics and Evolution2014，，： | 1 |
| 5 | Recent advancements in noninvasive brain modulation for individuals with autism spectrum disorder显示文摘Autism spectrum disorder is classified as a spectrum of neurodevelopmental disorders with an unknown definitive etiology.Individuals with autism spectrum disorder show deficits in a variety of areas including cognition,memory,attention,emotion recognition,and social skills.With no definitive treatment or cure,the main interventions for individuals with autism spectrum disorder are based on behavioral modulations.Recently,noninvasive brain modulation techniques including repetitive transcranial magnetic stimulation,intermittent theta burst stimulation,continuous theta burst stimulation,and transcranial direct current stimulation have been studied for their therapeutic properties of modifying neuroplasticity,particularly in individuals with autism spectrum disorder.Preliminary evidence from small cohort studies,pilot studies,and clinical trials suggests that the various noninvasive brain stimulation techniques have therapeutic benefits for treating both behavioral and cognitive manifestations of autism spectrum disorder.However,little data is available for quantifying the clinical significance of these findings as well as the long-term outcomes of individuals with autism spectrum disorder who underwent transcranial stimulation.The objective of this review is to highlight the most recent advancements in the application of noninvasive brain modulation technology in individuals with autism spectrum disorder. | Jessica R.Griff Jake Langlie Nathalie B.Bencie Zachary J.Cromar Jeenu Mittal Idil Memis Steven Wallace Alexander E.Marcillo Rahul Mittal Adrien A.Eshraghi | 2023 | Neural Regeneration Research2023，18，6： | 0 |
| 6 | Recent advancements toward gapless neural-electrode interface post-cochlear implantation显示文摘Cochlear implants(CI) are widely used to provide auditory rehabilitation to individuals with moderate to severe sensorineural hearing loss(Eshraghi et al., 2012). The scala tympani(ST) of the cochlea is the site of implantation of the intracochlear electrode array. | Crystal Y.Li Rahul Mittal Jenna Bergman Jeenu Mittal Adrien A.Eshraghi | 2021 | Neural Regeneration Research2021，16，9： | 0 |
| 7 | Unraveling pathological mechanisms in neurological disorders:the impact of cell-based and organoid models显示文摘Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug therapies.The greatest challenge is creating cell-based models that encapsulate the vast phenotypic presentations as well as the underlying genotypic etiology of these conditions.In this article,we discuss the recent advancements in cell-based models for understanding the pathophysiology of neurological disorders.We reviewed studies discussing the progression of cell-based models to the advancement of three-dimensional models and organoids that provide a more accurate model of the pathophysiology of neurological disorders in vivo.The better we understand how to create more precise models of the neurological system,the sooner we will be able to create patient-specific models and large libraries of these neurological disorders.While three-dimensional models can be used to discover the linking factors to connect the varying phenotypes,such models will also help to understand the early pathophysiology of these neurological disorders and how they are affected by their environment.The three-dimensional cell models will allow us to create more specific treatments and uncover potentially preventative measures in neurological disorders such as autism spectrum disorder,Parkinson’s disease,Alzheimer’s disease,and amyotrophic lateral sclerosis. | Jake Langlie Rahul Mittal Ariel Finberg Nathalie B.Bencie Jeenu Mittal Hossein Omidian Yadollah Omidi Adrien A.Eshraghi | 2022 | Neural Regeneration Research2022，17，10： | 0 |
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