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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Inhibition ofgene expression in mice muscle by in vivo electrically mediated siRNA delivery 显示文摘 | GOLZIO M MAZZOLINI L MOLLER P | 2005 | Gene Ther2005，12，3： | 1 |
| 3 | In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery显示文摘 | Golzio M Mazzolini L Ledoux A | 2007 | Gene Therapy2007，14，9： | 1 |
| 4 | Sphingosine kinase - 1 as a chemotherapy sensor in prostate adenoearcinoma cell and mouse models 显示文摘 | Pchejetski D Golzio M Bonhoure E | 2005 | Cancer Res2005，65，11： | 1 |
| 5 | Optical imaging of in vivo gene expression: a critical assessment of the methodology and associated technologies显示文摘 | Golzio M Rols MP Gabriel B | 2004 | Gene Ther2004，11，1： | 1 |
| 6 | Sphingosine kinase -1 as a chemotherapy sensor in prostate adenocarcinoma cell andmouse models显示文摘 | Pchejetski D Golzio M Bonhoure E | 2005 | Cancer Res2005，65，11： | 1 |
| 7 | Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery显示文摘 | Golzio M Mazzolini L Moiler P | 2005 | Gene Ther2005，12，3： | 1 |
| 8 | In vitro and in vivo electric field-mediated permeabilization, gene transfer, and expres sion显示文摘 | GOLZIO M ROLS M P TEISSIE J | 2004 | Methods2004，33，2： | 1 |
| 9 | Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models 显示文摘 | Pchejetski D Doumerc N Golzio M | 2008 | Mol Cancer Ther2008，7，7： | 1 |
| 10 | Direct visualization at the single-cell level of electrically mediated gene delivery 显示文摘 | Golzio M Teissie J Rols MP | 2002 | Proc Nat Acad Sci USA2002，99，3： | 1 |
| 11 | New insights in the visualization of membrane permeabilization and DNA/membrane interaction of cells submitted to electric pulses显示文摘 | PHEZ E FAURIE C GOLZIO M | 2005 | Biochimica et Biophysica Acta (BBA)2005，1724，3： | 1 |
| 12 | Accuracy of swabs,tissue specimens,and lead samples in diagnosis of cardiac rhythm management device infections显示文摘 | GOLZIO PG VINCI M ANSELMINO M | 2009 | Pacing Clin Electrophysiol2009，32，1： | 1 |
| 13 | Sphingosinekinase-1as a chemotherapy sensor in prostate adenocarcinomacell and mouse models显示文摘 | Pchejetski D Golzio M Bonhoure E | 2005 | Cancer Res2005，65，11： | 1 |
| 14 | Direct visualization at the sin gle-cell level of electrically mediated gene delivery显示文摘 | Golzio M Teissie J Rols M P | 2002 | Proceed ings of National Academy of Science of the USA2002，99，3： | 1 |
| 15 | Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence显示文摘 | Benko S Fantes JA Amiel J Kleinjan DJ Thomas S Ramsay J Jamshidi N Essafi A Heaney S Gordon CT McBride D Golzio C Fisher M Perry P Abadie V Ayuso C Holder-Espinasse M Kilpatrick N Lees MM Picard A Temple IK Thomas P Vazquez MP Vekemans M Roest Crollius H | | 0，，03： | 1 |
| 16 | Electro-mediated gene transfer and expression are controlled by the life-time of DNA/membrane complex formation显示文摘 | Faurie C Rebersek M Golzio M | 2010 | J Gene Med2010，12，1： | 1 |
| 17 | Direct visualization at the single-cell level of electrically mediated gene delivery显示文摘 | Golzio M Teissie J Rols M P | 2002 | Proc Natl Acad Sci USA2002，99，3： | 1 |
| 18 | Effect of electric field induced transmembrane potential on spheroidal cells : theo- ry and experiment显示文摘 | VALIC B GOLZIO M PAVLIN M | 2003 | European Biophysics Journal2003，32，6： | 1 |
| 19 | Sphingosine kinase - 1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models 显示文摘 | Pchejetski D Golzio M Bonhoure E | 2005 | Cancer Res2005，65，11： | 1 |
| 20 | Mechanisms of cell membrane electropermeabilization:a minireview of our present knowledge显示文摘 | Teissie J Golzio M Rols MP | 2005 | Biochim Biophys Acta2005，1，724： | 1 |
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