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| 1 | UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer显示文摘AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy. | Christoph Schulz Volker Heinemann Andreas Schalhorn Nikolas Moosmann Thomas Zwingers Stefan Boeck Clemens Giessen Hans-Joachim Stemmler | 2009 | World Journal of Gastroenterology2009，15，40： | 31 |
| 2 | Beam switching and bifocal zoom lensing using active plasmonic metasurfaces显示文摘Compact nanophotonic elements exhibiting adaptable properties are essential components for the miniaturization of powerful optical technologies such as adaptive optics and spatial light modulators.While the larger counterparts typically rely on mechanical actuation,this can be undesirable in some cases on a microscopic scale due to inherent space restrictions.Here,we present a novel design concept for highly integrated active optical components that employs a combination of resonant plasmonic metasurfaces and the phase-change material Ge3Sb2Te6.In particular,we demonstrate beam switching and bifocal lensing,thus,paving the way for a plethora of active optical elements employing plasmonic metasurfaces,which follow the same design principles. | Xinghui Yin Tobias Steinle Lingling Huang Thomas Taubner Matthias Wuttig Thomas Zentgraf Harald Giessen | 2017 | Light(Science & Applications)2017，6，1： | 12 |
| 3 | Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use显示文摘Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via endoscopes.Miniaturized endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to tissue.However,current fabrication methods limit the imaging performance of highly miniaturized probes,restricting their widespread application.To overcome this limitation,we developed a novel ultrathin probe fabrication technique that utilizes 3D microprinting to reliably create side-facing freeform micro-optics(<130μm diameter)on single-mode fibers.Using this technique,we built a fully functional ultrathin aberration-corrected optical coherence tomography probe.This is the smallest freeform 3D imaging probe yet reported,with a diameter of 0.457 mm,including the catheter sheath.We demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse arteries.The ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease. | Jiawen Li Simon Thiele Bryden C.Quirk Rodney W.Kirk Johan W.Verjans Emma Akers Christina A.Bursill Stephen J.Nicholls Alois M.Herkommer Harald Giessen Robert A.McLaughlin | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 4 | Selected issues at the interface between nuclear physics and astrophysics as well as the standard model显示文摘The density functional theory (DFT) with a minimal number of parameters allows a very successful phenomenological description of ground state properties of nuclei all over the periodic table. The recent developments on the application of the covariant density functional theory as well as its extensions by the group in Beijing for a series of interests and hot topics in nuclear astrophysics and nuclear structure are reviewed, including the rapid neutron-capture process, Th/U chronometer, and isospin corrections for superallowed β transitions. | MENG Jie1,2,3, NIU ZhongMing1, LIANG HaoZhao1 & SUN BaoHua2,4 1State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871, China 2School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191, China 3Department of Physics, University of Stellenbosch, Stellenbosch, South Africa 4Justus-Liebig-Universita¨t Giessen, Heinrich-Buff-Ring 14, Giessen 35392, Germany | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S1： | 5 |
| 5 | Robust and rapidly tunable light source for SRS/CARS microscopy with low-intensity noise显示文摘We present a fully automated laser system with low-intensity noise for coherent Raman scattering microscopy.The robust two-color system is pumped by a solid-state oscillator,which provides Stokes pulses fixed at 1043 nm.The tunable pump pulses of 750 to 950 nm are generated by a frequency-doubled fiberfeedback femtosecond optical parametric oscillator.The resulting pulse duration of 1.2 ps provides a viable compromise between optimal coherent Raman scattering signal and the necessary spectral resolution.Thus a spectral range of 1015 to 3695 cm−1 with spectral resolution of<13 cm−1 can be addressed. | Heiko Linnenbank Tobias Steinle Florian Morz Moritz Flöss Han Cui Andrew Glidle Harald Giessen | 2019 | Advanced Photonics2019，1，5： | 4 |
| 6 | Tunable and switchable polarization rotation with non-reciprocal plasmonic thin films at designated wavelengths显示文摘We experimentally demonstrate an ultra-thin plasmonic optical rotator in the visible regime that induces a polarization rotation that is continuously tunable and switchable by an external magnetic field.The rotator is a magneto-plasmonic hybrid structure consisting of a magneto-optical EuSe slab and a one-dimensional plasmonic gold grating.At low temperatures,EuSe possesses a large Verdet constant and exhibits Faraday rotation,which does not saturate over a regime of several Tesla.By combining these properties with plasmonic Faraday rotation enhancement,a large tuning range of the polarization rotation of up to 8.4° for a film thickness of 220 nm is achieved.Furthermore,through experiments and simulations,we demonstrate that the unique dispersion properties of the structure enable us to tailor the wavelengths of the tunable polarization rotation to arbitrary spectral positions within the transparency window of the magneto-optical slab.The demonstrated concept might lead to important,highly integrated,non-reciprocal,photonic devices for light modulation,optical isolation,and magnetic field optical sensing.The simple fabrication of EuSe nanostructures by physical vapor deposition opens the way for many potentially interesting magneto-plasmonic systems and three-dimensional magneto-optical metamaterials. | Dominik Floess Jessie Y Chin Akihito Kawatani Daniel Dregely Hanns-Ulrich Habermeier Thomas Weiss Harald Giessen | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 7 | Important progress on the use of isotope techniques and methods in catchment hydrology显示文摘The use of isotope techniques and methods in catchment hydrology in the last 50 years has generated two major types of progress: (1) Assessment of the temporal variations of the major stocks and flows of water in catchments, from which the estimation of wa-ter residence times is introduced in this paper. (2) Assessment of catchment hydrologic processes, in which the interactions be-tween different waters, hydrographical separation, and bio-geochemical process are described by using isotopes tracers. Future progress on isotope techniques and methods in hydrology is toward the understanding of the hydrological process in large river basins. Much potential also waits realization in terms of how isotope information may be used to calibrate and test distributed rainfall-runoff models and regarding aid in the quantification of sustainable water resources management. | JinKui Wu 1,2, YongJian Ding 1, BaiSheng Ye 1, QiYue Yang 3, Zhi Wei 1 1. Key Laboratory of Ecological Hydrology and Basin Sciences in Cold and Arid Regions Environmental and Engineering Re-search Institute, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China. 2. Institute for Landscape Ecology and Resources Management, Justus-Liebig-University Giessen, Giessen 35392, Germany. 3. College of Earth and Environmental Science, Lanzhou University, Lanzhou, Gansu 730000, China. | 2009 | Research in Cold and Arid Regions2009，1，3： | 4 |
| 8 | Phyllotaxis-inspired nanosieves with multiplexed orbital angular momentum显示文摘Nanophotonic platforms such as metasurfaces,achieving arbitrary phase profiles within ultrathin thickness,emerge as miniaturized,ultracompact and kaleidoscopic optical vortex generators.However,it is often required to segment or interleave independent sub-array metasurfaces to multiplex optical vortices in a single nano-device,which in turn affects the device’s compactness and channel capacity.Here,inspired by phyllotaxis patterns in pine cones and sunflowers,we theoretically prove and experimentally report that multiple optical vortices can be produced in a single compact phyllotaxis nanosieve,both in free space and on a chip,where one meta-atom may contribute to many vortices simultaneously.The time-resolved dynamics of on-chip interference wavefronts between multiple plasmonic vortices was revealed by ultrafast time-resolved photoemission electron microscopy.Our nature-inspired optical vortex generator would facilitate various vortex-related optical applications,including structured wavefront shaping,free-space and plasmonic vortices,and high-capacity information metaphotonics. | Zhongwei Jin David Janoschka Junhong Deng Lin Ge Pascal Dreher Bettina Frank Guangwei Hu Jincheng Ni Yuanjie Yang Jing Li Changyuan Yu Dangyuan Lei Guixin Li Shumin Xiao Shengtao Mei Harald Giessen Frank Meyer zu Heringdorf Cheng-Wei Qiu | 2021 | eLight2021，1，1： | 3 |
| 9 | Indentation of elastically soft and plastically compressible solids显示文摘The effect of soft elasticity, i.e., a relatively small value of the ratio of Young's modulus to yield strength and plastic compressibility on the indentation of isotropically hardening elastic–viscoplastic solids is investigated. Calculations are carried out for indentation of a perfectly sticking rigid sharp indenter into a cylinder modeling indentation of a half space. The material is characterized by a finit strain elastic–viscoplastic constitutive relation that allows for plastic as well as elastic compressibility. Both soft elasticity and plastic compressibility significantl reduce the ratio of nominal indentation hardness to yield strength. A linear relation is found between the nominal indentation hardness and the logarithm of the ratio of Young's modulus to yield strength, but with a different coefficien than reported in previous studies.The nominal indentation hardness decreases rapidly for small deviations from plastic incompressibility and then decreases rather slowly for values of the plastic Poisson's ratio less than0.25. For both soft elasticity and plastic compressibility, the main reason for the lower values of indentation hardness is related to the reduction in the hydrostatic stress level in the material below the indenter. | A.Needleman V.Tvergaard E.Van der Giessen | 2015 | Acta Mechanica Sinica2015，31，4： | 3 |
| 10 | Effects of microstructure on crack tip fields and fracture toughness in PC/ABS polymer blends显示文摘 | Thomas Seelig Erik Giessen | 2007 | International Journal of Fracture2007，，3： | 2 |
| 11 | Do you want to participate in a clinical study as a healthy control?-Risk or benefit?显示文摘A healthy woman volunteered to participate as 'healthy control' in a study.An increased level of procalcitonin(PCT) was detected and remained elevated on follow-up measurements.As calcitonin levels were elevated as well,thyroid ultrasound was performed which revealed nodes in both thyroid lobes,one of them showing metabolic activity in positron emission tomography-computed tomography scan.To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma(MTC) was detected in the right lobe.MTC is a rare endocrine tumor with a poor prognosis once having spread,therefore early detection remains a priority for the outcome.Screening parameter is serum calcitonin,in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity. | Hanna Giessen Christian A Nebiker Matthias Bruehlmeier Stefan Spreitzer Beat Mueller Philipp Schuetz | 2017 | World Journal of Clinical Cases2017，5，12： | 2 |
| 12 | 3D-printed miniature spectrometer for the visible range with a 100×100μm^(2) footprint显示文摘The miniaturisation of spectroscopic measurement devices opens novel information channels for size critical applications such as endoscopy or consumer electronics.Computational spectrometers in the micrometre size range have been demonstrated,however,these are calibration sensitive and based on complex reconstruction algorithms.Herein we present an angle-insensitive 3D-printed miniature spectrometer with a direct separated spatial-spectral response.The spectrometer was fabricated via two-photon direct laser writing combined with a super-fine inkjet process.It has a volume of less than 100×100×300μm^(3).Its tailored and chirped high-frequency grating enables strongly dispersive behaviour.The miniature spectrometer features a wavelength range of 200 nm in the visible range from 490 nm to 690 nm.It has a spectral resolution of 9.2±1.1 nm at 532 nm and 17.8±1.7 nm at a wavelength of 633 nm.Printing this spectrometer directly onto camera sensors is feasible and can be replicated for use as a macro-pixel of a snapshot hyperspectral camera. | Andrea Toulouse Johannes Drozella Simon Thiele Harald Giessen Alois Herkommer | 2021 | Light(Advanced Manufacturing)2021，2，1： | 2 |
| 13 | Early tumor shrinkage in patients with metastatic colorectal cancer receiving first-line treatment with cetuximab combined with either CAPIRI or CAPOX: An analysis of the German AIO KRK 0104 trial显示文摘 | Dominik P. Modest Ruediger P. Laubender Sebastian Stintzing Clemens Giessen Christoph Schulz Michael Haas Ulrich Mansmann Volker Heinemann | 2013 | Acta Oncologica2013，，5： | 2 |
| 14 | Cell transplantation for cardiac regenerarion:where do we stand? 显示文摘 | van den Bos E J van der Giessen WJ Duncker DJ | 2008 | Neth Heart J2008，16，3： | 1 |
| 15 | Plaque and shear stress distribution in human coronary bifurcations: a multislice computed tomography study 显示文摘 | van der Giessen AG Wentzel J J Meijboom WB | 2009 | EuroIntervention2009，4，： | 1 |
| 16 | Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation显示文摘 | Andrew T.L. Ong Angela Hoye Jiro Aoki Carlos A.G. van Mieghem Gaston A. Rodriguez Granillo Karel Sonnenschein Evelyn Regar Eugene P. McFadden Georgios Sianos Willem J. van der Giessen Peter P.T. de Jaegere Pim de Feyter Ron T. van Domburg Patrick W. Serru | 2005 | Journal of the American College of Cardiology2005，，6： | 1 |
| 17 | A concise review of DNA damage checkpoints and repair in mammalian ceils 显示文摘 | Houtpraaf JH Versmissen J van der Giessen WJ | 2006 | Cardiovasc Revasc Med2006，7，3： | 1 |
| 18 | A concise review of DNA damage checkpoints and repair in mammalian cells显示文摘 | HOUTGRAAF JH VERSMISSEN J VAN DER GIESSEN WJ | 2006 | CardioRevasc Med2006，7，3： | 1 |
| 19 | In vivo validation of a novel three-dimensional quantitative coronary angiography system (CardiOp-B):Comparison with a conventional two-dimensional system (CAAS Ⅱ) and with special reference to optical coherence tomography显示文摘 | Tsuchida K Van der Giessen W J Patterson M | | 0，，： | 1 |
| 20 | Heparincoated Palmaz-schatz stents in human coronary arteries: early outcome of the Benestent-Ⅰ piliot study显示文摘 | Emanuelsson H Van der Giessen | 1996 | Circulation1996，93，： | 1 |
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