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| 1 | Responses of grassland vegetation to climatic variations on different temporal scales in Hulun Buir Grassland in the past 30 years显示文摘全球温暖特别在过去的 20 年里导致了重要植被变化。在内部蒙古的 Hulun Buir 草地,世界之一三个大草原,正在经历突出的温暖并且弄干的一个过程。为气候的变化的更好的理解在植被动力学上调查气候的变化(温度和降水) 的效果是必要的。NDVI (规范的差别植被索引) ,植物生长的思考特征,植被范围和生物资源,被用作指示物监视植被变化。从 1981 ~ 2006 的 GIMMS NDVI 和从 2000 ~ 2009 的 MODIS NDVI 被采用并且集成于到植被的时间系列特征在 Hulun Buir 改变的摘录的这研究草地。到每年、季节、每月的规模上的气候的变化的植被范围的回答被分析与温度和七个气象学的地点的降水数据结合了。在过去的 30 年里,植被范围是更多与气候的因素相关,并且关联依赖于时间规模。在内部年度的规模上,植被变化更好与降水被相关,建议降雨是为驾驶植被变化的主要因素。在 seasonal-interannual 规模上,在植被范围变化和气候的因素之间的关联证明到水、热的条件变化的植被生长的敏感在不同季节是不同的。当它到在夏天和秋天的降雨的敏感更高时,到在夏天的温度的植被生长的敏感比在另外的季节高,特别在夏天。在 monthly-interannual 规模上,在植被范围变化和气候的因素之间的关联在生长季节期间证明在 4 月和 5 月的温度的植被变化的反应更强壮。这显示温度效果发生在植被生长的早阶段。在植被生长和在当前的月前的月的降水之间的关联,从 5 月更好到 8 月,显示出植被生长的磁滞现象回答到降雨。草变得绿并且开始在草生长上在温度的 4 月,和影响成长是明显的。在 4 月的 NDVI 的增加可能由于气候的温暖那导致一个先进生长季节。在摘要,在植被范围和气候的因素的 monthly-interannual 变化之间的关系大部分在草生长上代表温度和降水的时间的节奏控制。 | ZHANG Geli XU Xingliang ZHOU Caiping ZHANG Hongbin OUYANG Hua | 2011 | Journal of Geographical Sciences2011，21，4： | 20 |
| 2 | Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles显示文摘AIM: To prepare the chitosan-pmEpo nanoparticles and to study their ability for transcellular and paracellular transport across intestinal epithelia by oral administration. METHODS: ICR mice were fed with recombinant plasmid AAV-tetO-CMV-mEpo (containing mEpo gene) or pCMVβ(containing LacZ gene), whether it was wrapped by chitosan or no. Its size and shape were observed by transmission electron microscopy. Agarose gel electrophoresis was used to assess the efficiency of encapsulation and stability against nuclease digestion. Before and after oral treatmant, blood samples were collected by retro-orbital puncture, and hematocrits were used to show the physiological effect of mEpo. RESULTS: Chitosan was able to successfully wrap the plasmid and to protect it from DNase degradation. Transmission electron microscopy showed that freshly prepared particles were approximately 70-150 nm in size and fairly spherical.Three days after fed the chitosan-pCMVβ complex was fed,the mice were killed and most of the stomach and 30% of the small intestine were stained. Hematocrit was not modified in naive and ‘naked' mEpo-fed mice, a rapid increase of hematocrit was observed during the first 4 days of treatment in chitosan-mEpo-fed animals, reaching 60.9±1.2% (P<0.01),and sustained for a week. The second feed (6 days after the first feed) was still able to promote a second hematocrit increase in chitosan-mEpo-fed animals, reaching 65.9±1.4%(P<0.01), while the second hematocrit increase did not appearin the ‘naked' mEpo-second-fed mice. CONCLUSION: Oral chitosan-DNA nanoparticles can efficiently deliver genes to enterocytes, and may be used as a useful tool for gene transfer. | JingChen Wu-LiYang GeLi JiQian Jing-LunXue Shou-KuanFu Da-RuLu | 2004 | World Journal of Gastroenterology2004，10，1： | 10 |
| 3 | Protective effects of acupuncture and LGNHFD on expressions of vascular endothelial growth factor, basic fibroblast growth factor,and cluster of differentiation 34 in rats with cerebral ischemia-reperfusion injury显示文摘OBJECTIVE: To investigate the protective effects of electroacupuncture and LGNHFD on cerebral ischemia-reperfusion injury, and their effects on the expression of cluster of differentiation 34(CD 34), vascular endothelial growth factor(VEGF), and basic fibroblast growth factor(b FGF) in the peripheral tissue of the cerebral ischemic semi-dark zone in rats.The influence and mechanism of expression.METHODS: Healthy male Sprague-Dawley rats were randomly divided into the sham operation group, model group, Traditional Chinese Medicine (TCM) group, electroacupuncture group, and acupuncture group. The cerebral ischemia model was prepared by middle artery occlusion. The electroacupuncture and TCM groups received electroacupuncture at the 'Neiguan(PC6)', 'Baihui(GV20)', and 'Renzhong(GV26)' acupoints from 4 h after modeling, once daily for 14 d. After modeling,the acupuncture and TCM groups were administered LGNHFD once daily for 14 d. After treatment,the infarct volume and regional cerebral blood flow(r CBF) were measured in each group, the expression of CD34 in the surrounding ischemic penumbra was determined using immunohistochemistry,and the expression of angiogenesis-related factors in the ischemic hemisphere was detected by western blot.RESULTS: Compared with the sham operation group, r CBF was significantly decreased(P < 0.01)and cerebral infarction volume was significantly increased(P < 0.01) in the model group at four time points(5 min and 3, 7, and 14 d after modeling). At three postoperative time points(3, 7, and 14 d), the number of CD34 + cells in the model group were significantly increased(P < 0.01), and the relative expression levels of VEGF, b FGF, and CD34+ in the ischemic hemisphere were significantly increased(P < 0.01, P < 0.05). Compared with the model group, the r CBF of the acupuncture group was significantly increased at 3, 7, and 14 d after intervention(P < 0.01), while the r CBF of the electroacupuncture and TCM groups was significantly increased at 7 and 14 d after intervention(P < 0.01).After 3, 7, and 14 d of intervention, infarct volume was significantly reduced(P < 0.01), the number of CD34 + cells was significantly increased(P < 0.01,P < 0.05), and the relative expression levels of VEGF,b FGF, and CD34 in the ischemic hemisphere were significantly increased(P < 0.01, P < 0.05). Compared with the electroacupuncture and TCM groups, the r CBF of the acupuncture group was significantly increased(P < 0.01), the infarct volume was significantly reduced(P < 0.01), and the relative expression levels of VEGF, b FGF, and CD34 were significantly increased(P < 0.05, P < 0.01) after 3, 7,and 14 d of intervention.CONCLUSION: Acupuncture therapy is superior to simple drug and electroacupuncture therapy for reducing infarct volume, increasing r CBF and CD34 expression in cells, and promoting capillary regeneration in rats with cerebral ischemia. This may be related to the increased expression of VEGF, b FGF,and CD34 — which are related to cerebrovascular neovascularization — in the ischemic hemispheres of such rats. | YANG Le YANG Baocun ZHANG Caixia TONg Jie FENG Geli XIAO Gaiqin | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 8 |
| 4 | Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARg/NF-kB/IL-6 signaling pathway显示文摘Traumatic brain injury(TBI)is the major cause of high mortality and disability rates worldwide.Pioglitazone is an activator of peroxisome proliferator-activated receptor-gamma(PPARγ)that can reduce inflammation following TBI.Clinically,neuroinflammation after TBI lacks effective treatment.Although there are many studies on PPARγin TBI animals,only few could be converted into clinical,since TBI mechanisms in humans and animals are not completely consistent.The present study,provided a potential theoretical basis and therapeutic target for neuroinflammation treatment after TBI.First,we detected interleukin-6(IL-6),nitric oxide(NO)and Caspase-3 in TBI clinical specimens,confirming a presence of a high expression of inflammatory factors.Western blot(WB),quantitative real-time PCR(qRTPCR)and immunohistochemistry(IHC)were used to detect PPARγ,IL-6,and p-NF-kB to identify the mechanisms of neuroinflammation.Then,in the rat TBI model,neurobehavioral and cerebral edema levels were investigated after intervention with pioglitazone(PPARγactivator)or T0070907(PPARγinhibitor),and PPARγ,IL-6 and p-NF-kB were detected again by qRT-PCR,WB and immunofluorescence(IF).The obtained results revealed that:1)increased expression of IL-6,NO and Caspase-3 in serum and cerebrospinal fluid in patients after TBI,and decreased PPARγin brain tissue;2)pioglitazone could improve neurobehavioral and reduce brain edema in rats after TBI;3)the protective effect of pioglitazone was achieved by activating PPARγand reducing NF-kB and IL-6.The neuroprotective effect of pioglitazone on TBI was mediated through the PPARγ/NF-kB/IL-6 pathway. | Yongbing Deng Xue Jiang Xiaoyan Deng Hong Chen Jie Xu Zhaosi Zhang Geli Liu Zhu Yong Chengfu Yuan Xiaochuan Sun Changdong Wang | 2020 | Genes & Diseases2020，7，2： | 6 |
| 5 | A novel approach in predicting non-stationary time series by combining external forces显示文摘In this paper, we investigate a novel technique that reconstructs the observed time series and incorporates driving forces. Furthermore, to illustrate and test the technique, we consider a couple of predictive experiments using ideal time series provided by the logistic and Lorenz systems with specific driving forces. The preliminary results show this approach can improve prediction proficiency to some extent, and the external forces play a similar role to that of state variables. | WANG GeLi YANG PeiCai BIAN JianChun ZHOU XiuJi | 2011 | Chinese Science Bulletin2011，56，28： | 5 |
| 6 | Comparison of the patient and partner satisfaction with 700CX and Titan penile prostheses显示文摘最普遍的三部件的阴茎修复术模型是 700CX 和泰坦 ? 。在第一植入以后,我们的目的是估计病人和搭挡满足。这是 multicenter,回顾,满足了在 2009 和 2013 之间的包括标准的所有病人在被包括的 nonrandomized 学习。总共, 248 个病人同意参与。评估耐心的满足,一张验证,但是修改的 11 问题问询表被完成(编辑) ;并且二条款的问询表被给搭挡的 nonvalidated。统计分析使用了一个顺序的逻辑回归模型。248 个病人(194 与 700CX 对 54 与泰坦 ?) 和 207 对夫妇完成了问询表(165 与 700CX 对 42 与泰坦 ?) 。全面满足高。为有优先的期望的性交和高依从的两个都显示出的大可靠性。大多数病人能在 6 个月以内正确地管理阴茎修复术。手术后的阴茎弄短在 42% 盒子和 46% 中导致了一些不满(700CX /Titan ?) 。重要差别在病人问询表的三个问题被发现。有更多的病人,对 700CX 满意(P = 0.0001 ) 。有泰坦 ? 的没有病人植入比 6 个月长带了去最佳的管理。仅仅,有 700CX 的 4% 病人植入与泰坦 ? 与放气被不满足,与 24% 相对照(P = 0.0031 ) 。二个搭挡问题,一个人显示出统计上重要的差别(P = 0.0026 ) 。看起来,组 700CX 将推荐到重新植入有一个更大的趋势的修复术。全面满足为两 prostheses 很高。最后的方面树立,松驰的阴茎是令人满意的,但是两个组与它的最后的尺寸显示出重要不满。搭挡外套满足高。 | Javier Romero Otero Cesar Rojas Cruz Borja Garcia Gomez Joaquim Sarquella Geli lose Medina Polo Eduard Ruiz Castane Alfredo Rodriguez Antolin | 2017 | Asian Journal of Andrology2017，19，3： | 3 |
| 7 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 8 | Spatial and temporal variation characteristics of ocean waves in the South China Sea during the boreal winter显示文摘The spatial and temporal variation characteristics of the waves in the South China Sea(SCS) in the boreal winter during the period of 1979/1980–2011/2012 have been investigated based on the European Centre for Medium-range Weather Forecasts interim(ERA-Interim) reanalysis dataset. The results show that the leading mode of significant wave height anomalies(SWHA) in the SCS exhibits significant interannual variation and a decadal shift around the mid-1990 s, and features a basin-wide pattern in the entire SCS with a center located in the west of the Luzon Strait. The decadal change from a weak regime to a strong regime is mainly associated with the enhancement of winter monsoon modulated by the Pacific decadal oscillation(PDO). The interannual variation of the SWHA has a significant negative correlation with the El Ni?o Southern Oscillation(ENSO) in the same season and the preceding autumn. For a better understanding of the physical mechanism between the SCS ocean waves and ENSO, further investigation is made by analyzing atmospheric circulation. The impact of the ENSO on the SWHA over the SCS is bridged by the East Asian winter monsoon and Pacific-East Asian teleconnection in the lower troposphere. During the El Ni?o(La Ni?a), the anomalous Philippine Sea anticyclone(cyclone) dominates over the Western North Pacific, helps to weaken(enhance) East Asian winter monsoon and then emerges the negative(positive) SWHA in the SCS. | ZHU Geli LIN Wantao ZHAO Sen CAO Yanhua | 2015 | Acta Oceanologica Sinica2015，34，1： | 2 |
| 9 | The Color Glass Condensate显示文摘 | Francois Gelis Edmond Iancu Jamal Jalilian-Marian Raju Venugopalan | 2010 | Annual Review of Nuclear and Particle Science2010，，1： | 2 |
| 10 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 11 | Argonaute-2 regulates the proliferation of adult stem cells in planarian显示文摘 | Yong-QinLi AnZeng Xiao-ShuaiHan ChenWang GeLi Zhen-ChaoZhang Jian-YongWang Yong-WenQin QingJing | 2011 | Cell Research2011，21，12： | 2 |
| 12 | Dynamic load balancing by diffusion in heterogeneous systems显示文摘 | Rotaru T and N~geli H | 2004 | Journal of Parallel and Distributed Computing2004，64，4： | 1 |
| 13 | Strategies of heavy metal uptake by three plant species growing near a metal smelter 显示文摘 | Dahmani-Muller H Van O F Gelie B | 2000 | Environmental Pollution2000，109，2： | 1 |
| 14 | IORT in breast carcinomas 显示文摘 | Dubois JB Hay M Gely S | 1997 | Front Radiat Ther Oncol1997，31，： | 1 |
| 15 | Methylation of the pl6INKgA promoter is associated with malignant behavior in abdominal extra- adrenal paragangliomas but not pheochromocytomas 显示文摘 | Kiss N Geli J Lundberg F | 2008 | Endocr Relat Cancer2008，15，2： | 1 |
| 16 | Strategies of heavy metal uptake by three plant species growing near a metal smelter显示文摘 | Dahmain-Muller H van Oort F Gelie B 2000 | 2000 | Environmental pollution2000，109，2： | 1 |
| 17 | Strategies of heavy metal uptake by three plant species growing near a metal smelter显示文摘 | DAHMANI MULLER H OORT F VAN GELIE B | 2000 | Environ Pollut2000，109，2： | 1 |
| 18 | Progesterone regulates ILl2 expression in pregnancy lymphocytes by inhibiting pbospholipase A2 显示文摘 | Par G Geli J Kozma N | 2003 | Am J Reprod Immunol2003，49，1： | 1 |
| 19 | Progesterone Regulates IL/2 Expression in pregnancy Lymphocytes by Inhibiting phospholipase A2 显示文摘 | Par G Geli J Kozma N | 2008 | Am J Reprod Immunol2008，49，1： | 1 |
| 20 | Two α(1,2) fucosyltransferase genes on porcine Chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci显示文摘 | E. Meijerink R. Fries P. V?geli J. Masabanda G. Wigger C. Stricker S. Neuenschwander H.U. Bertschinger G. Stranzinger | 1997 | Mammalian Genome1997，，10： | 1 |
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