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| 1 | Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARg/NF-kB/IL-6 signaling pathway显示文摘Traumatic brain injury(TBI)is the major cause of high mortality and disability rates worldwide.Pioglitazone is an activator of peroxisome proliferator-activated receptor-gamma(PPARγ)that can reduce inflammation following TBI.Clinically,neuroinflammation after TBI lacks effective treatment.Although there are many studies on PPARγin TBI animals,only few could be converted into clinical,since TBI mechanisms in humans and animals are not completely consistent.The present study,provided a potential theoretical basis and therapeutic target for neuroinflammation treatment after TBI.First,we detected interleukin-6(IL-6),nitric oxide(NO)and Caspase-3 in TBI clinical specimens,confirming a presence of a high expression of inflammatory factors.Western blot(WB),quantitative real-time PCR(qRTPCR)and immunohistochemistry(IHC)were used to detect PPARγ,IL-6,and p-NF-kB to identify the mechanisms of neuroinflammation.Then,in the rat TBI model,neurobehavioral and cerebral edema levels were investigated after intervention with pioglitazone(PPARγactivator)or T0070907(PPARγinhibitor),and PPARγ,IL-6 and p-NF-kB were detected again by qRT-PCR,WB and immunofluorescence(IF).The obtained results revealed that:1)increased expression of IL-6,NO and Caspase-3 in serum and cerebrospinal fluid in patients after TBI,and decreased PPARγin brain tissue;2)pioglitazone could improve neurobehavioral and reduce brain edema in rats after TBI;3)the protective effect of pioglitazone was achieved by activating PPARγand reducing NF-kB and IL-6.The neuroprotective effect of pioglitazone on TBI was mediated through the PPARγ/NF-kB/IL-6 pathway. | Yongbing Deng Xue Jiang Xiaoyan Deng Hong Chen Jie Xu Zhaosi Zhang Geli Liu Zhu Yong Chengfu Yuan Xiaochuan Sun Changdong Wang | 2020 | Genes & Diseases2020，7，2： | 6 |
| 2 | Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice显示文摘 | Chengfu Yuan Xiuning Huang Li Cheng Youquan Bu Geli Liu Faping Yi Zhengmei Yang Fangzhou Song | 2008 | Food Chemistry2008，，2： | 1 |
| 3 | Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice显示文摘 | Chengfu Yuan Changdong Wang Youquan Bu Tingxiu Xiang Xiuning Huang Zhiwei Wang Faping Yi Guosheng Ren Geli Liu Fangzhou Song | 2010 | Immunology Letters2010，，1： | 1 |
| 4 | Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice显示文摘 | Chengfu Yuan Changdong Wang Youquan Bu Tingxiu Xiang Xiuning Huang Zhiwei Wang Faping Yi Guosheng Ren Geli Liu Fangzhou Song | 2010 | Immunology Letters2010，，1： | 1 |
| 5 | Clinical features of post?infectious bronchiolitis obliterans in childrenundergoing long?term azithromycin treatment显示文摘 | Xueyan Wang Changshan Liu Mengjuan Wang Yi Zhang Hewen Li Geli Liu | 2015 | Experimental and Therapeutic Medicine2015，，6： | 1 |
| 6 | ARHGEF38 as a novel biomarker to predict aggressive prostate cancer显示文摘Prostate cancer(PCa)metastasis is considered the leading cause of cancer death in males.Therapeutic strategies and diagnosis for stage-specific PCa have not been well understood.Rho guanine nucleotide exchange factor 38(ARHGEF38)is related to tumor cell polarization and is frequently expressed in PCa.Microarray data of PCa were downloaded from GEO and TCGA databases.A total of 243 DEGs were screened,of which,32 genes were upregulated.The results of enrichment analysis showed the participation of these DEGs in the tumor cell metastasis pathway.ARHGEF38 was significantly up-regulated in the four most prevalent cancers worldwide(p<0.05),and its expression was higher in the tumor samples with higher Gleason score(GS).IHC,qRT-PCR,and western-blot analyses showed the higher expression of ARHGEF38 in PCa than benign prostatic hyperplasia(BPH).In addition,IHC results demonstrated a higher expression of ARHGEF38 in high-grade PCa than the low-grade PCa. | Kun Liu Aixiang Wang Longke Ran Wanfeng Zhang Song Jing Yujing Wang Xianqin Zhang Geli Liu Wang Sen Fangzhou Song | 2020 | Genes & Diseases2020，7，2： | 0 |
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