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| 1 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 2 | IORT in breast carcinomas 显示文摘 | Dubois JB Hay M Gely S | 1997 | Front Radiat Ther Oncol1997，31，： | 1 |
| 3 | Calcium efflux is essential for bacterial survival in the eukaryotic host 显示文摘 | Jason W R Jack S Geli G | 2008 | Molecular Microbiology2008，70，2： | 1 |
| 4 | Pga13 in Candida albi- cans is localized in the cell wall and influences cell surface prop- erties, morphogenesis and virulence 显示文摘 | Gelis S de Groot PW Castillo L | 2012 | Fungal Genet Biol2012，49，4： | 1 |
| 5 | IORT in breast carcinomas显示文摘 | Dubois JB Hay M Gely S | 1997 | Front Radiat Ther Oncol1997，31，： | 1 |
| 6 | Characterization of liver lesions by real-time contrast-enhanced ultrasonography显示文摘 | Geli N Gaiani S Piscaglia F | 2007 | Eur J Gastroenterol Hepatol2007，19，1： | 1 |
| 7 | Assessment of the skin photoproteetive capacities of an organo-mineral broad- spectrum sunblock on two exvivo skin models 显示文摘 | Gelis C Girard S Mavon A | 2003 | Photochem Photobiol2003，19，5： | 1 |
| 8 | Pgal3 in Candida al- bicans is localized in the cell wall and influences cell surface properties, morphogenesis and virulence显示文摘 | Gelis S de Groot P W Castillo L | 2012 | Fungal Genet Biol2012，49，4： | 1 |
| 9 | Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR显示文摘 | BERNARD C GELY S BOURHIS JM | 2009 | FEBS Lett2009，583，7： | 1 |
| 10 | Adaptation to potassium starva- tion of wild - type and K ( + ) - transport mutant ( trkl, 2 ) of Saccharomyces cerevisiae:2 - dimensional gel electrophoresis - based proteomic approach 显示文摘 | Gelis S Curto M Valledor L | 2012 | Microbiologyopen2012，1，2： | 1 |
| 11 | Assessment of the skin photoprotective capacities of an organo-mineral broadspectrum sunblock on two ex vivo skin models 显示文摘 | Gelis C Girard S Mavon A | 2003 | Photodermatol Photoimmunol Photamed2003，19，5： | 1 |
| 12 | Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models显示文摘 | Gelis C Girard S Mavon A Delverdier M Paillous N Vicendo P | 2003 | Photodermatol Photoimmunol Photomed2003，19，5： | 1 |
| 13 | IORT in breast carcinomas显示文摘 | Dubois JB Hay M Gely S | 1997 | Front Radiat Ther Oncol1997，31，： | 1 |
| 14 | Calcium efflux is essential forbacterial survival in the eukaryotic host显示文摘 | JASON W RJACK S GELI G | 2008 | MolecularMicrobiology2008，70，2： | 1 |
| 15 | Macrophage foam cell from experimental atheroma constitutively produce matrixdegrading protenases显示文摘 | Gelis ZS Sukhova GK Kranzhofer R Clauk S Libby P | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 16 | Clinical and Electrophysiological Research on Sick Sinus Syndrome Treated with Acupuncture显示文摘ClinicalandElectrophysiologicalResearchonSickSinusSyndromeTreatedwithAcupuncture￥JiangGeli;LuShaoqiang;LuoLi(No.464HospitalOf... | Jiang Geli Lu Shaoqiang Luo Li(No. 464 Hospital Of Chinese People’s Liberation Army No.1 Teaching Hospital of Tianjin Chinese Medicine College) | 1995 | 中国针灸1995，15，S2： | 0 |
| 17 | Acupuncture Effect on Electrophysiology of Experimental Bradycardia and Tachycardia显示文摘AcupunctureEffectonElectrophysiologyofExperimentalBradycardiaandTachycardia￥JiangGeli;MaJinquan(NO.464HospitalofChinesePelple... | Jiang Geli Ma Jinquan(NO. 464 Hospital of Chinese Pelple’s Liberation Army,Tianjin Cardiac Institute) | 1995 | 中国针灸1995，15，S2： | 0 |
| 18 | 嗜铬细胞瘤与颅内出血 | Gelis A. Pelissier J. Blard J.M. Pagès M 王晓琳 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，4： | 0 |
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