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| 1 | 外科手术中产生的烟气:仅仅是大量的热空气吗?显示文摘外科医生和手术室人员经常接触手术设备产生的烟气,病人也会暴露于烟气中,特别是腹腔镜手术中产生的烟气滞留于腹腔内这一密闭空间并被吸收。这些烟气是一种与香烟烟气相似的毒性物质,然而对这种毒性物质的影响还未引起足够重视。应该采取必要措施尽可能减少手术中烟气的不良影响。 | Barrett WL Garber SM 黄文海 朱江帆(摘译) | 2005 | 中国微创外科杂志2005,5,4: | 17 |
| 2 | p63基因在肺癌组织中的表达显示文摘目的 研究肺鳞状细胞癌、腺癌、大细胞肺癌、小细胞肺癌以及淋巴结或肺内转移性肿瘤标本组织中p63基因的mRNA转录因子和蛋白表达水平,探讨p63基因表达与其定位在3q 27-q29区域改变的关系。方法 采用cDNA微阵列技术同时检测72例不同病理组织学类型的原发性肺癌(包括鳞状细胞癌、腺癌、大细胞癌、小细胞癌)和肺癌肺内转移及淋巴结转移灶内的p63基因mRNA水平。另外,利用组织芯片技术构建150例原发性肺癌石蜡包埋标本组织芯片,采用免疫组织化学LSAB法检测p63基因蛋白表达情况。同时应用比较基因组杂交(CGH)技术对70例原发性肺癌标本进行了3号染色体长臂改变的分析。结果 p63mRNA转录因子在肺鳞状细胞癌标本表达明显增强,与腺癌、大细胞癌、小细胞癌相比增多10倍以上。肺癌转移灶内p63基因mRNA表达水平明显高于其相对应的原发性灶,差异有统计学意义(P<0.001)。免疫组织化学染色结果显示:肺鳞状细胞癌阳性表达率为94.64%;腺癌是1.79%;4例大细胞肺癌中2例为阳性染色;但所有小细胞肺癌标本免疫组织化学染色均为阴性。pT1分期肺癌的p63基因蛋白表达阳性率与pT2分期肺癌相比有统计学差异(P<0.05)。比较基因组杂交结果发现:肺鳞状细胞癌3号染色体长臂27-29区域有显著的扩增,腺癌表现为缺失。鳞状细胞癌p63基因的? | 余永伟 Mitchell E Garber KarstenSchlüns ManuelaPacyna-Gengelbach IverPetersen | 2004 | 中华病理学杂志2004,33,4: | 7 |
| 3 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009,,6: | 5 |
| 4 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial显示文摘 | Alan Garber Robert Henry Robert Ratner Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvera-Alvarez Paula M Hale Milan Zdravkovic Bruce Bode | 2009 | The Lancet2009,,9662: | 2 |
| 5 | Post‐liver transplantation sarcopenia in cirrhosis: A prospective evaluation显示文摘 | Cynthia Tsien Ari Garber Arvind Narayanan Shetal N Shah David Barnes Bijan Eghtesad John Fung Arthur J McCullough Srinivasan Dasarathy | 2014 | J Gastroenterol Hepatol2014,,6: | 2 |
| 6 | Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise显示文摘 | Carol Ewing Garber Bryan Blissmer Michael R. Deschenes Barry A. Franklin Michael J. Lamonte I-Min Lee David C. Nieman David P. Swain | 2011 | Medicine & Science in Sports & Exercise2011,,7: | 2 |
| 7 | Defining the spermatogonial stem cell显示文摘 | F. Kent Hamra Nikolaus Schultz Karen M. Chapman Dana M. Grellhesl Jennifer T. Cronkhite Robert E. Hammer David L. Garbers | 2004 | Developmental Biology2004,,2: | 2 |
| 8 | From Density to Destiny: Using Spatial Dimension of Sales Data for Early Prediction of New Product Success显示文摘 | Tal Garber Jacob Goldenberg Barak Libai Eitan Muller | 2004 | Marketing Science2004,,3: | 2 |
| 9 | Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN) 显示文摘 | Gao Z Harumi T Garbers D L | 1997 | Genomics1997,41,1: | 1 |
| 10 | Stomach contents of juvenile Cobia, Rachycentron canadum, from the northern Gulf of Mexico 显示文摘 | Franks J S Garber N M Warren J R | 1996 | Fishery Bulletin1996,94,2: | 1 |
| 11 | Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes : differences among 4 racial/ethnic groups 显示文摘 | Rosenberg TJ Garbers S Lipkind H | 2005 | Am J Public Health2005,95,: | 1 |
| 12 | Depression in Children and Adolescents Linking Risk Research and Prevention显示文摘 | Garber J | 2006 | American Journal of Preventive Medicine2006,31,6: | 1 |
| 13 | Effect of relaxin in two models of renal mass reduction 显示文摘 | Garber SL Mirochnik Y Brecklin C | 2003 | Am J Nephrol2003,23,1: | 1 |
| 14 | Attainment of glycaemic goals in type diabetes with oncce, twice or thrice daily dosing with biphasic insulin aspart 70/30 (The 1-2-3 study) 显示文摘 | Garber AJ Wahlen J Wahl T | 2006 | Diabetes Obes Metab2006,,8: | 1 |
| 15 | A novel CDK9-associated C-type cyclin in- teracts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA 显示文摘 | Wei P Garber ME Fang SM | 1998 | Cell1998,92,4: | 1 |
| 16 | Energy deregulation: licensing tumors to grow显示文摘 | Garber K | 2006 | Science2006,312,5777: | 1 |
| 17 | Epithelial-to-mesenchymal transition is important to metastasis, but questions remain显示文摘 | Garber K | 2008 | J Natl Cancer Inst2008,100,23: | 1 |
| 18 | Immediate total tooth replacement 显示文摘 | Garber DA Salama MA Salama H | 2001 | Compend Contin Educ Dent2001,22,3: | 1 |
| 19 | Liralutide versus glimepiridemonotherapy for type 2 diabetes(LEAD-3 Mono):a radomised,52-week,phase,III,double-blind,parallel-treatment trial显示文摘 | Garber A Henry R Ratner R | 2009 | Lancet2009,373,9662: | 1 |
| 20 | Type 2 diabetes and cardiovascular risk factors显示文摘 | Sharma MD Farmer JA Garber A | 2011 | Current Med Res Opinion2011,27,3: | 1 |