|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 2 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 3 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 4 | Analysis of Hydrocarbon Mixture Performance of a Dual-Channel Swirl Engine显示文摘In order to understand and improve the oil and gas mixing performance of a dual-channel vortex chamber diesel engine,the BH175F dual-channel vortex chamber combustion system was used as the research foundation,and the oil-gas mixture process of the combustion system was numerically analyzed.By analyzing the cylinder temperature,cylinder pressure,mixing process and combustion process of the combustion system,the mixture performance of the combustion system was studied.Results indicated that:The mixture of the compression Top Dead Center(TDC)started to enter the main combustion chamber through the start-up hole;when the piston reached 4°After Top Dead Center(ATDC),the mixture started to enter the main combustion chamber through the connecting channels A and B,and the high-concentration mixture entered the main combustion from the start-up hole;when the piston continued running down to 20°and 25°ATDC,it could be seen that the main combustion chamber mixture was already relatively uniform;besides,when the equivalence ratio was between 0.8 and 1,the air-ftiel mixture was unevenly distributed in the main combustion chamber.It provides guidance for further improvement of the combustion system. | YUAN Wenhua HUANG Qilin FU Jun LIAO Jingjing LI Yu HE Yong ZHANG Zengfeng MA Yi | 2020 | Journal of Thermal Science2020，29，6： | 1 |
| 5 | Sericin microparticles enveloped with metal-organic networks as a pulmonary targeting delivery system for intra-tracheally treating metastatic lung cancer显示文摘Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer.However,systemic chemotherapy is limited by poor therapeutic efficiency and severe toxic side effects,due to the extremely low delivery efficacy and non-specificity of anticancer drugs.Herein,we report a sericin microparticles enveloped with metal-organic networks as a pulmonary delivery system for treating lung metastasis of breast cancer in an animal model.The sericin microparticles(SMPs)were prepared using water in oil(w/o)emulsification method.After doxorubicin(DOX)loading,tannic acid(TA)/ferric irons(Fe3+)based metal organic networks(MON)were coated on the particles to obtain DOX-loaded microparticles(DOX@SMPs-MON).The SMPs-MON with good biocompatibility could effectively encapsulate DOX and sustainably unload cargos in a pH-dependent manner.The DOX-loaded microparticles could be uptaken by 4T1 cells,and effectively kill the cancer cells.In vivo,DOX@SMPs-MON was deposited in the lungs and remained for over 5 days after pulmonary administration.In contrast to conventional DOX treatment that did not show significantly inhibitory effects on lung metastatic tumor,DOX@SMPs-MON markedly decreased the number and size of metastatic nodules in lungs,and the lung weight and appearance were similar to those of healthy mice.In summary,the sericin microparticles with MON wrapping might be a promising pulmonary delivery system for treating lung metastatic cancer. | Jia Liu Yan Deng Daan Fu Ye Yuan Qilin Li Lin Shi Guobin Wang Zheng Wang Lin Wang | 2021 | Bioactive Materials2021，6，1： | 1 |
| 6 | Reduction of acrylamide formation by selected agents in fried potato crisps on industrial scale显示文摘 | Shiyi Ou Qilin Lin Yuping Zhang Caihuan Huang Xi Sun Liang Fu | 2007 | Innovative Food Science and Emerging Technologies2007，，1： | 1 |
| 7 | Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles显示文摘Neutrophil extracellular traps(NETs)have been considered a significant unfavorable factor for wound healing in diabetes,but the mechanisms remain unclear.The therapeutic application of small extracellular vesicles(sEVs)derived from mesenchymal stem cells(MSCs)has received considerable attention for their properties.Hypoxic preconditioning is reported to enhance the therapeutic potential of MSC-derived sEVs in regenerative medicine.Therefore,the aim of this study is to illustrate the detailed mechanism of NETs in impairment of diabetic wound healing and develop a promising NET-targeting treatment based on hypoxic pretreated MSC-derived sEVs(Hypo-sEVs).Excessive NETs were found in diabetic wounds and in high glucose(HG)-induced neutrophils.Further research showed that high concentration of NETs impaired the function of fibroblasts through activating endoplasmic reticulum(ER)stress.Hypo-sEVs efficiently promoted diabetic wound healing and reduced the excessive NET formation by transferring miR-17-5p.Bioinformatic analysis and RNA interference experiment revealed that miR-17-5p in Hypo-sEVs obstructed the NET formation by targeting TLR4/ROS/MAPK pathway.Additionally,miR-17-5p overexpression decreased NET formation and overcame NET-induced impairment in fibroblasts,similar to the effects of Hypo-sEVs.Overall,we identify a previously unrecognized NET-related mechanism in diabetic wounds and provide a promising NET-targeting strategy for wound treatment. | Ziqiang Chu Qilin Huang Kui Ma Xi Liu Wenhua Zhang Shengnan Cui Qian Wei Huanhuan Gao Wenzhi Hu Zihao Wang Sheng Meng Lige Tian Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Bioactive Materials2023，，9： | 1 |
| 8 | On Budapest School Aesthetics: An Interview with Agnes Heller显示文摘 | Fu Qilin | 2008 | Thesis Eleven2008，，： | 1 |
| 9 | The Significances of Roland Barthes’ Analysis of Popular Culture显示文摘罗兰·巴特关于大众文化分析的意义在于突出符号学和意识形态这两个重要关键词,建立起大众文化的符号意识形态分析的基本范式,显示了马克思主义文化理论的当代阐释力量。这种范式内在于马克思主义文化理论传统,并与中国马克思主义大众文化理论有着相关性和差异性。 | Qilin FU | 2015 | Comparative Literature:East & West2015，，2： | 0 |
| 10 | The Chinese Localization of Foreign Marxist Literary Theory——A Key Project on Eastern-European Marxist Literary Theory显示文摘虽然国外马克思主义文论的本土化在中国学界已经得到关注与研究,但是仍然留下诸多空白,尤其是对一些重要的理论问题的本土化思考和对典型个案的本土化清理尚未系统地展开。本文依托国家社科基金重点项目'国外马克思主义文论的本土化研究'的思路,概括国外马克思主义文论的本土化的三个主要历史阶段,凝聚国外马克思主义文论本土化的六个重要理论焦点,并从东欧马克思主义文论的视角出发考察涉及国外马克思主义文论本土化的六个典型个案,具体把握国外马克思主义本土化的特征、运作机制及其价值意义。文章最后指出,在全球化语境中,中国文学界需要进一步深入国外马克思主义文论的本土化进程,在多元话语的碰撞中发展具有世界性和民族性的文学理论,在跨文化交流中发出中国学者独特的声音。 | Qilin FU | 2014 | Comparative Literature:East & West2014，，2： | 0 |
| 11 | The Relationship between Civil&Commercial Law and Economic Law in the Context of the Market Economy显示文摘Both civil&commercial law and economic law are the main legal basis for supervising market behavior and regulating market order.They are indispensable laws in the national economic development and construction.By analyzing the relationship between civil&commercial law and economic law in the context of market economy,this article explores the similarities and differences between,and through the perfection and application of the two,China’s social and economic stability and a lasting progress can be better realized under the mechanism of market economy. | Ding Yanshen Fu Qilin | 2020 | 学术界2020，，7： | 0 |
| 12 | A Study of Agnes Heller’s Thoughts on Aestketic Modernity:An Abstract显示文摘本文从审美现代性的角度切入布达佩斯学派主要哲学家阿格妮丝·赫勒的美学思想。首先清理典型的审美现代性理论与赫勒的审美现代性理论框架,然后从文艺复兴时期的审美现代性、现代领域分化过程中的审美领域、现代美学体系与道德美学四个方面进行具体展开,最后指出其美学思想的当代意义。 | Fu Qilin Sichuan University | 2007 | Comparative Literature:East & West2007，，1： | 0 |
| 13 | A review on treatment of disinfection byproduct precursors by biological activated carbon process显示文摘Disinfection by-products(DBPs)in water systems have attracted increasing attention due to their toxic effects.Removal of precursors(mainly natural organic matter(NOM))prior to the disinfection process has been recognized as the ideal strategy to control the DBP levels.Currently,biological activated carbon(BAC)process is a highly recommended and prevalent process for treatment of DBP precursors in advanced water treatment.This paper first introduces the fundamental knowledge of BAC process,including the history,basic principles,typical process flow,and basic operational parameters.Then,the selection of BAC process for treatment of DBP precursors is explained in detail based on the comparative analysis of dominant water treatment technologies from the aspects of mechanisms for NOM removal as well as the treatability of different groups of DBP precursors.Next,a thorough overview is presented to summarize the recent developments and breakthroughs in the removal of DBP precursors using BAC process,and the contents involved include effect of pre-BAC ozonation,removal performance of various DBP precursors,toxicity risk reduction,fractional analysis of NOM,effect of empty bed contact time(EBCT)and engineered biofiltration.Finally,some recommendations are made to strengthen current research and address the knowledge gaps,including the issues of microbial mechanisms,toxicity evaluation,degradation kinetics and microbial products. | Jie Fu Ching-Hua Huang Chenyuan Dang Qilin Wang | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员