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| 1 | c-Met targeted therapy of cholangiocarcinoma显示文摘Cholangiocarcinoma continues to be a challenging disease to treat. Systemic therapy is used in unresectable disease, disease progression after surgery, and in the palliative setting. Unfortunately, results of multiple phase Ⅱ trials have rarely yielded positive results. As data on the molecular carcinogenesis of cholangiocarcinoma is developing, we are more able to understand the disease process and can use this understanding to create unique targeted therapies. We reviewed the role of c-Met/ hepatocyte growth factor (HGF) in the development of cholangiocarcinoma. Furthermore, we explored the use of the c-Met guided cascade as a target to treat cholangiocarcinoma. We reviewed the current use and options for future development of c-Met agents to treat this disease. | Matei P Socoteanu Frank Mott Gianfranco Alpini Arthur E Frankel | 2008 | World Journal of Gastroenterology2008，14，19： | 16 |
| 2 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 3 | The forces and moments in the leg during level walking显示文摘 | FRANKEL B BRESLER J P | 1950 | J Appl Mech1950，72，： | 1 |
| 4 | Role of grain boundary precipitates and solute-depleted zone on the intergranular corrosion of aluminum alloy 7150显示文摘 | Ramgopal T Gouma P I Frankel G S | 2002 | Corrosion2002，58，8： | 1 |
| 5 | Carbo-platin and paclitaxel in combination with either vorinostat or pla-cebo for first-line therapy of advanced non-small-cell lung cancer显示文摘 | RAMALINGAM SS MAITLAND ML FRANKEL P | 2009 | J Clin Oncol2009，28，1： | 1 |
| 6 | Comparison of residual stresses in Ti - 6AL- 4V and Ti - 6AL- 2Sn - 4Zr-2Mo linear friction welds 显示文摘 | Frankel P Preussl M Steuwer A | 2009 | Materials Science and Technology2009，25，5： | 1 |
| 7 | Discretionary disclosure and external financing显示文摘 | Frankel R McNichols M Wilson G P | 1995 | Accounting Review1995，70，1： | 1 |
| 8 | Neuropilins: structure,function and role in disease显示文摘 | Pellet-Many C Frankel P Jia H | 2008 | Biochem J2008，411，2： | 1 |
| 9 | Multiple biomarker expression on circulating tumor cells in comparison to tumor tissues from primary and metastatic sites in patients with locally advanced/inflammatory,and stage IV breast cancer,using a novel detection technology显示文摘 | SOMLO G LAU S K FRANKEL P | 2011 | Breast Cancer Res Treat2011，128，1： | 1 |
| 10 | Programmed Cell Death 4 is an important functional target of the microRNA miR-21 in breast cancer cells显示文摘 | Frankel LB Yao H Zhu P | | 0，，02： | 1 |
| 11 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 12 | Fe3O4 precipitation in magnetotactic bacteria显示文摘 | Frankel R B Papaefthymiou G C Blakemore R P | 1983 | Biphys Acta1983，763，： | 1 |
| 13 | Discretionary disclosure and external financing 显示文摘 | Frankel R McNichols M Wilson G P | 1995 | The Accounting Review1995，，70： | 1 |
| 14 | Differentiation therapy of acute promyelocytic leukima with tretinoin (all-trans retinoic acid) 显示文摘 | Warell R P Jr Frankel S R Miller W H Jr | 1991 | N Engl J Med1991，324，20： | 1 |
| 15 | Prognostic indicators and sur-vival in patients with stage IIIB inflammatory breast carcinoma af- ter dose-intense chemotherapy 显示文摘 | Somlo G Frankel P Chow W | 2004 | Clin Oncol2004，22，10： | 1 |
| 16 | Role of grainboundary precipitates and solute-depleted zone on the intergranular corrosion of aluminum alloy 7150显示文摘 | RAMGOPAL T GOUMA P I FRANKEL G S | 2002 | Corrosion2002，58，8： | 1 |
| 17 | Update in the diagnosis and management of pulmonary vasculitis显示文摘 | Frankel S K Cosgrove G P Fischer A | 2006 | Chest2006，129，2： | 1 |
| 18 | Chemistry and biology of the ramoplanin family of peptide antibiotics 显示文摘 | MeCafferty D G Cudie P Frankel B A | 2002 | Bioploymers2002，66，： | 1 |
| 19 | Weight of in- ternal organs and caracse yield of early food restricted broilers 显示文摘 | Susbilla J P Frankel T L Parkinson G | 1994 | British Poultry Science1994，35，5： | 1 |
| 20 | Inhibition of in vitro human LDL oxidation by phenolic antioxidants from grapes and wines 显示文摘 | Teissedre P L Frankel E N Waterhouse A L | 1996 | Journal of the Science of Food and Agriculture1996，70，1： | 1 |
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