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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 3 | Magnetic resonance imaging in the diagnosis of lumbar spinal canal stenosis显示文摘 | Postacchini F Amatruda A Morace GB | 1991 | Ital J Orthop Traumatol1991，17，3： | 1 |
| 4 | The development of an immobilized enzyme reactor containing glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi:the effect of species' specific differences on the immobilization显示文摘 | C.L.Cardoso M.C.de Moracs R.V.C.Guido | | 0，，： | 1 |
| 5 | Multicenter comparative evaluation of six commercial systems and the national committee for clinical laboratory standards M27-a broth microdilufion method for fluanazde susceptibility testing of Candida species显示文摘 | Morace G Amato G Bistoni F | 2002 | J Clin Microbiol2002，40，8： | 1 |
| 6 | Identification of various medically important Candida species in clinical specimens by PCR-restriction enzyme analysis 显示文摘 | Morace G Sanguinetti M Posteraro B | 1997 | J Clin Microbiol1997，35，3： | 1 |
| 7 | Fungal infections in ICU patients: epidemiology and the role of diagnostics显示文摘 | MORACE G BORGHI E | 2010 | Minerva Anestesiol2010，76，11： | 1 |
| 8 | Multicenter comparative evaluation of six commercial systems and the national committee for clinical laboratory standards M27-A susceptibility testing of Candida species显示文摘 | Morace G Amato G Bistoni F | 2002 | J Clin Microbiol2002，4，： | 1 |
| 9 | Mutations in the 3A genomie region of two eytopathic strains of hepatitis A virus isolated in Italy显示文摘 | Morace G Pisani F Beneduce M | 1993 | Virus Res1993，28，： | 1 |
| 10 | PCR-reatriction emyme analysis for detection of Candida DNA in blood from febrile patients with hematological malignancies显示文摘 | Morace G Pagano L Sanguinetti M | 1999 | J Clin Microbiol1999，37，6： | 1 |
| 11 | Identification of various medically important Candida species in clinical specimens by PCR-restriction enzyme analysis 显示文摘 | Morace G Sanguinetti M Posteraro B | 1997 | J Clin Microbiol1997，35，3： | 1 |
| 12 | Study of some physical properties of biodegradable films based on blends of gelatin and poly(vinyl alcohol) using a response - surface methodology 显示文摘 | Carvallao R A Maria T M C Moracs I C F | 2009 | Materials Science and Engineering C2009，29，： | 1 |
| 13 | Mutation in the 3A genomic region of two cytopathic strains of hepatitis A virus isolated in Italy显示文摘 | Morace G Pisani G Beneduce F | 1993 | Virus Res1993，28，： | 1 |
| 14 | Analysis of Thermomechanical Behaviour of Nitinol Wires with High Strain Rates显示文摘 | Vitiello A Giorleo G Morace R E | 2005 | Smart Material Structure2005，14，1： | 1 |
| 15 | lnfiammatory parameters are independently associated with urinary albumil in type 2 diabetes mellitus显示文摘 | NavarroJ F MoraC Maca M el al | 2003 | Am J Kidney Dis2003，42，1： | 1 |
| 16 | Interaction of hepatitis A virus (HAV) precursor proteins 3AB and 3ABC with the 5' and 3' termini of the HAV RNA 显示文摘 | Kusov Y Y Morace G Probst C | 1997 | Virus Res1997，51，2： | 1 |
| 17 | Percutaneous uhrosound -guided renal biopsy in children a safety, effciany, indication and renal patholy显示文摘 | Piotto GH Moracs MC Malheiros DM | 2008 | Clin Neprol2008，69，6： | 1 |
| 18 | Identification of Various Medically Important Candida Species in Clinical Specimens by PCR-Restriction Enzyme Analysis显示文摘 | Morace G Sanguinetti M Posteraro B | 1997 | J Clin Microbiol1997，35，3： | 1 |
| 19 | The role of inflammation as pathogenic factor in the develop-ment of renal disease in diabetes显示文摘 | MoraC Navarro JF | 2005 | Curr Diab Rep2005，5，6： | 1 |
| 20 | Inflammation and diabetic nephropa- thy 显示文摘 | MoraC Navano JF | 2006 | Curr Diab Rep2006，6，6： | 1 |
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