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| 1 | Wireless capsule endoscopy and proximal small bowel lesions in Crohn’s disease显示文摘AIM: To investigate the prevalence of proximal small bowel (SB) lesions detected by wireless capsule endoscopy (WCE) in Crohn's disease (CD). METHODS: WCE was performed in 64 patients: 32 with CD of the distal ileum, and 32 controls with iron-deficiency anemia (IDA) or diarrhea. WCE was performed using the Given SB-WCE, followed by small intestine contrast ultrasonography (SICUS). Findings compatible with CD by using WCE included erosions, aphthoid or deep ulcers, and strictures/stenosis. RESULTS: WCE detected proximal SB lesions in 16/32 (50%) patients (14 aphthoid ulcers, 2 deep ulcers, one stricture), which appeared not to be related to clinical parameters [epigastric pain, age, smoking, non-steroidalanti-inflammatory drugs (NSAIDs), IDA]. Among patients with proximal SB lesions, 6 (37%) were smokers, 3 (19%) NSAID users, 3 (19%) had epigastric pain and 4 (25%) had IDA. SICUS detected proximal SB lesions in 3/32 patients (19%) also showing lesions with WCE. No correlations were observed between proximal SB lesions assessed by WCE or by SICUS (χ2 = 1.5, P = 0.2). CONCLUSION: The use of WCE allows the detection of previously unknown upper SB lesions in a high proportion of patients with a previous diagnosis of CD involving the distal ileum. | Carmelina Petruzziello Sara Onali Emma Calabrese Francesca Zorzi Marta Ascolani Giovanna Condino Elisabetta Lolli Paola Naccarato Francesco Pallone Livia Biancone | 2010 | World Journal of Gastroenterology2010，16，26： | 7 |
| 2 | Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn's disease显示文摘AIM:To compare computed tomography enteroclysis(CTE) vs small intestine contrast ultrasonography(SICUS) for assessing small bowel lesions in Crohn's disease(CD),when using surgical pathology as gold standard.METHODS:From January 2007 to July 2008,15 eligible patients undergoing elective resection of the distal ileum and coecum(or right colon) were prospectively enrolled.All patients were under follow-up.The study population included 6 males and 9 females,with a median age of 44 years(range:18-80 years).Inclusion criteria:(1) certain diagnosis of small bowel requiring elective ileo-colonic resection;(2) age between 18-80 years;(3) elective surgery in our Surgical Unit;and(4) written informed consent.SICUS and CTE were performed ≤ 3 mo before surgery,followed by surgical pathology.The following small bowel lesions were blindly reported by one sonologist,radiologist,surgeon and histolopathologist:disease site,extent,strictures,abscesses,fistulae,small bowel dilation.Comparison between findings at SICUS,CTE,surgical specimens and histological examination was made by assessing the specificity,sensitivity and accuracy of each technique,when using surgical findings as gold standard.RESULTS:Among the 15 patients enrolled,CTE was not feasible in 2 patients,due to urgent surgery in one patients and to low compliance in the second patient,refusing to perform CTE due to the discomfort related to the naso-jejunal tube.The analysis for comparing CTE vs SICUS findings was therefore performed in 13 out of the 15 CD patients enrolled.Differently from CTE,SICUS was feasible in all the 15 patients enrolled.No complications were observed when using SICUS or CTE.Surgical pathology findings in the tested population included:small bowel stricture in 13 patients,small bowel dilation above ileal stricture in 10 patients,abdominal abscesses in 2 patients,enteric fistulae in 5 patients,lymphnodes enlargement(> 1 cm) in 7 patients and mesenteric enlargement in 9 patients.In order to compare findings by using SICUS,CTE,histology and surgery,characteristics of the small bowel lesions observed in CD each patient were blindly reported in the same form by one gastroenterologistsonologist,radiologist,surgeon and anatomopathologist.At surgery,lesions related to CD were detected in the distal ileum in all 13 patients,also visualized by both SICUS and CTE in all 13 patients.Ileal lesions > 10 cm length were detected at surgery in all the 13 CD patients,confirmed by SICUS and CTE in the same 12 out of the 13 patients.When using surgical findings as a gold standard,SICUS and CTE showed the exactly same sensitivity,specificity and accuracy for detecting the presence of small bowel fistulae(accuracy 77% for both) and abscesses(accuracy 85% for both).In the tested CD population,SICUS and CTE were also quite comparable in terms of accuracy for detecting the presence of small bowel strictures(92% vs 100%),small bowel fistulae(77% for both) and small bowel dilation(85% vs 82%).CONCLUSION:In our study population,CTE and the non-invasive and radiation-free SICUS showed a comparable high accuracy for assessing small bowel lesions in CD. | Sara Onali Emma Calabrese Carmelina Petruzziello Francesca Zorzi Giuseppe Sica Roberto Fiori Marta Ascolani Elisabetta Lolli Giovanna Condino Giampiero Palmieri Giovanni Simonetti Francesco Pallone Livia Biancone | 2012 | World Journal of Gastroenterology2012，18，42： | 5 |
| 3 | A Multidisciplinary Method for Evaluating Ship Stability显示文摘 | Francesca Calabrese Luisa Mancarella Alessandro Antonio Zizzari Angelo Corallo | 2012 | Journal of Shipping and Ocean Engineering2012，2，6： | 3 |
| 4 | Titanium-coated polypropylene mesh as innovative bioactive material in conservatives mastectomies and pre-pectoral breast reconstruction显示文摘Breast reconstruction is rapidly evolving,thanks to the growing acceptance of synthetic meshes as innovative biomaterials.276 patients undergoing mastectomy(total of 328 mastectomies)were analyzed in a retrospective observational study to evaluate the pre-pectoral immediate breast reconstruction(IBR)using an implant wrapped with Titanium-Coated Polypropylene Mesh(TCPM)vs.patients treated with tissue expander(TE),equally placed pre-pectorally(and wrapped with the same TCPM in 74.3%of the control group’breasts).163 patients,of the study group(SG),underwent mastectomy and pre-pectoral IBR with implant wrapped with TCPM,in a one-step surgery,called direct-to-implant technique(DTI),while 113 patients control group(CG)underwent mastectomy and TE.DTI technique has been performed in 192 breasts of the SG while TE procedure in 136 breasts of the CG.The BREAST-Q questionnaire has been provided before the treatment and 2 years later.Baker scale has been used to evaluate capsular contracture.Oncologic,surgical,and aesthetic outcomes along with BREAST-Q scores were analyzed.Additionally,a histologic evaluation was conducted in 11 capsules’samples randomly chosen(6 derived from SG patients and 5 derived from CG).Complications were recorded in 43 cases(29SG-14CG):8 skin-nipple necrosis(5SG-3CG),8 wound dehiscence(6SG-2CG),3 hematomas(1SG-2CG),and 24 infections(8SG-16CG).Grade IV capsular contracture was detected in 9 breasts(1SG-8CG),whereas 254 breasts were grade I(110SG-144CG),33(10SG-23CG)grade II,and 32(4SG-28CG)grade III.Implant wrinkling was detected in 18 cases(10SG-8CG)after 30 months.The local tumor recurrence rate was 5.8%.Three recurrences were on the nipple-areola complex(1.9%).SG patients showed significantly higher rates in the BREAST-Q overall Satisfaction with Outcome(74.1),overall Satisfaction with Breasts(69.1),Psychosocial Well-being(81.9),and Sexual Well-being(63.1),versus CG’s patients(p<0.05).Histological analysis showed a process of normal tissue repair with a complete mesh integration and normal healing.Conservative mastectomies with pre-pectoral IBR assisted by TCPM proved themselves oncologically safe,biologically integrated into native tissues,and highly accepted in terms of quality of life guaranteeing a more natural and aesthetic breast appearance.Core tip:This retrospective observational study provided clinical and histological outcomes of the pre-pectoral IBR using an implant wrapped with TCPM vs.patients treated with TE,equally placed pre-pectorally.The efficacy of IBR using an implant wrapped with TCPM was confirmed by the cosmetic results obtained and by a rate of side effects comparable to TE.All the histological analyses performed confirmed the TCPM mesh complete integration with the physiological aspects of healing:The Collagen 1 and 3 expressions did not differ,between TCPM and NO TCPM samples to confirm a process of healing overlapping to perfect device incorporation and normal healing. | Pietro Gentile Marco Bernini Lorenzo Orzalesi Silvia Sordi Icro Meattini Francesca Lessi Ashutosh Kothari Claudio Calabrese | 2021 | Bioactive Materials2021，6，12： | 2 |
| 5 | Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress :Modulation by antidepressant treatment显示文摘 | Gianluigi Guidotti Francesca Calabrese Calabrese Anacker | 2013 | Neuropsychopharmacology2013，38，4： | 1 |
| 6 | A family study of asymptomatic small bowel Crohn’s disease显示文摘 | Livia Biancone Emma Calabrese Carmelina Petruzziello Alessandra Capanna Francesca Zorzi Sara Onali Giovanna Condino Elisabetta Lolli Cinzia Ciccacci Paola Borgiani Francesco Pallone | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 7 | Fistulizing pattern in Crohn’s disease and pancolitis in ulcerative colitis are independent risk factors for cancer: A single-center cohort study显示文摘 | Livia Biancone Sara Zuzzi Micaela Ranieri Carmelina Petruzziello Emma Calabrese Sara Onali Marta Ascolani Francesca Zorzi Giovanna Condino Simona Iacobelli Francesco Pallone | 2011 | Journal of Crohn’s and Colitis2011，，5： | 1 |
| 8 | Frequency, Pattern, and Risk Factors of Postoperative Recurrence of Crohn’s Disease After Resection Different from Ileo-Colonic显示文摘 | Sara Onali Carmelina Petruzziello Emma Calabrese Giovanna Condino Francesca Zorzi Giuseppe Sigismondo Sica Francesco Pallone Livia Biancone | 2009 | Journal of Gastrointestinal Surgery2009，，2： | 1 |
| 9 | Anti-TNF-alpha treatments and obstructive symptoms in Crohn’s Disease: A prospective study显示文摘 | Giovanna Condino Emma Calabrese Francesca Zorzi Sara Onali Elisabetta Lolli Fabiola De Biasio Marta Ascolani Francesco Pallone Livia Biancone | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 10 | Ultrasound of the Small Bowel in Crohn’s Disease显示文摘 | Emma Calabrese Francesca Zorzi Francesco Pallone Christoph Gasche | 2012 | International Journal of Inflammation2012，，： | 1 |
| 11 | Accuracy of Small-Intestine Contrast Ultrasonography, Compared With Computed Tomography Enteroclysis, in Characterizing Lesions in Patients With Crohn’s Disease显示文摘 | Emma Calabrese Francesca Zorzi Sara Onali Elisa Stasi Roberto Fiori Simonetta Prencipe Antonino Bella Carmelina Petruzziello Giovanna Condino Elisabetta Lolli Giovanni Simonetti Livia Biancone Francesco Pallone | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 1 |
| 12 | Impact of Primary Coronary Angioplasty Delay on Myocardial Salvage, Infarct Size, and Microvascular Damage in Patients With ST-Segment Elevation Myocardial Infarction显示文摘 | Marco Francone Chiara Bucciarelli-Ducci Iacopo Carbone Emanuele Canali Raffaele Scardala Francesca A. Calabrese Gennaro Sardella Massimo Mancone Carlo Catalano Francesco Fedele Roberto Passariello Jan Bogaert Luciano Agati | 2009 | Journal of the American College of Cardiology2009，，23： | 1 |
| 13 | Radiological clinical trials: Proposal of a problem-finding questionnaire to improve study success显示文摘AIM To develop a survey to help define the main problems in radiological clinical trials. METHODS Since 2006, we have managed seven different radiological clinical trials recruiting patients in academic and non-academic centres. We developed a preliminary questionnaire using a four-round Delphi approach to identify problems occurring in radiological clinical trials run at our centre. We investigated the recruitment experience, involvement of all multi-disciplinary team members and main obstacles to completing the projects. A final round of Delphi processes elucidated solutions to the identified problems.RESULTS Among 19/20(95%) respondents, 10(53%) were young physicians(under 35 years old), and the respondents included non-faculty members, fellows, residents, and undergraduate students. Ninety-four percent(18/19) of respondents showed interest in conducting clinical trials. On a scale of 1 to 10, the problems with higher/worse scores(8-9) were related to technical or communication problems. The most frequent problems across all studies were technical problems related to clinical trial equipment, insufficient willingness to participate, obstacles to understanding the design of electronic-case report form and extra work.CONCLUSION The developed questionnaire identified the main recurring problems in radiological clinical trials as perceived by endusers and helped define possible solutions that are mostly related to having dedicated clinical trial research staff. | Francesca Valdora Bianca Bignotti Massimo Calabrese Nehmat Houssami Alberto Tagliafico | 2016 | World Journal of Methodology2016，6，4： | 0 |
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