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2篇 您的检索式：作者名="Christopher Alexakis"

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		题名	作者	年代	出处	被引量
	1	Proposed case of mesalazine-induced cardiomyopathy in severe ulcerative colitis显示文摘Five-amino salicylic acids are recommended for use in the management of inflammatory bowel disease,cardiac complications are a rare although recognised phenomenon.This report aims to highlight this serious but rare adverse reaction.We report here a case of a young man presenting with cardiogenic shock in the context of recent mesalazine treatment in severe ulcerative colitis.	Kathryn Fleming Andrew Ashcroft Christopher Alexakis Demitrios Tzias Christopher Groves Andrew Poullis	2015	World Journal of Gastroenterology2015，21，11：	9
	2	Impact of thiopurines and anti-tumour necrosis factor therapy on hospitalisation and long-term surgical outcomes in ulcerative colitis显示文摘Ulcerative colitis(UC) is a chronic inflammatory condition affecting the large bowel and is associated with a significant risk of both requirement for surgeryand the need for hospitalisation. Thiopurines, and more recently, anti-tumour necrosis factor(a TNF) therapy have been used successfully to induce clinical remission. However, there is less data available on whether these agents prevent long-term colectomy rates or the need for hospitalisation. The focus of this article is to review the recent and pertinent literature on the long-term impact of thiopurines and a TNF on long-term surgical and hospitalisation rates in UC. Data from population based longitudinal research indicates that thiopurine therapy probably has a protective role against colectomy, if used in appropriate patients for a sufficient duration. a TNF agents appear to have a short term protective effect against colectomy, but data is limited for longer periods. Whereas there is insufficient evidence that thiopurines affect hospitalisation, evidence favours that a TNF therapy probably reduces the risk of hospitalisation within the first year of use, but it is less clear on whether this effect continues beyond this period. More structured research needs to be conducted to answer these clinically important questions.	Christopher Alexakis Richard CG Pollok	2015	World Journal of Gastrointestinal Surgery2015，7，12：	1

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