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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Paolo Muratori Luigi Muratori Rodolfo Ferrari Fabio Cassani Giampaolo Bianchi Marco Lenzi Luis Rodrigo Antonio Linares Dolores Fuentes Francesco B Bianchi | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 3 | Protein kinase G from pathogenic mycobacteria promotes survival within macrophages显示文摘 | Walburger A Koul A Ferrari G Nguyen L PrescianottoBaschong C Huygen K Klebl B Thompson C Bacher G Pieters J | 2004 | Science2004，304，5678： | 1 |
| 4 | Novel 7-oxvinlinonlethyl derivalives of camptotheein with polent in vilro and in vivo antitumor activity 显示文摘 | Dallavalle S Ferrari A Biasotti B | 2001 | J Med Chem2001，44，20： | 1 |
| 5 | Flavonoids and isoflavonoids from Zollernia paraensis显示文摘 | Ferrari F Botta B de Lima RA | 1983 | Phytochemistry1983，22，7： | 1 |
| 6 | The conductivity of aqueous Al2O3 slips for electrophoretic deposition显示文摘 | Ferrari B Moreno R | 1996 | Materials Letters1996，28，456： | 1 |
| 7 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 8 | Retinitis pigmen- tosa: genes and disease mechanisms 显示文摘 | Ferrari S Di Iorio B Barbaro B | 2011 | Curr Genomics2011，12，4： | 1 |
| 9 | Cyclin dependent kinases inhibitors and dominant negative cyclin deoendent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons显示文摘 | Park DS Levine B Ferrari G | 1997 | J Neurosci1997，17，23： | 1 |
| 10 | Leptin inhibits steroid biosynthesis by human granulose-lutein cells 显示文摘 | Barreca A Mastorakos G Furlini M Vottero A Ferrari B Chrousos GP Bernasconi S | 2001 | Horm Metab Res2001，33，6： | 1 |
| 11 | Electrophoretic deposition of MgO from organic suspensions显示文摘 | Ferrari B Moreno R Sarkar P | 2000 | Journal of the European Ceramic Society2000，20，2： | 1 |
| 12 | Influence of the impregnation order of molybdenum and cobalt in carbon-supported catalysts for hydrodeoxygenation reactions显示文摘 | Ferrari M Delmon B Grange P | | 0，，： | 1 |
| 13 | A New Series of Imidazolones:Highly Specific and Potent Nonpeptide AT1 Angiotensin II Receptor Antagonists 显示文摘 | Bemhart C A Perreaut P M Ferrari B P | 1993 | J Med Chem1993，36，22： | 1 |
| 14 | Template-impinted nanostructured swfaces for protein recognition 显示文摘 | Shi H Q Tsai W B Garrison M D Ferrari S Ratner B D | 1999 | Nature1999，398，6728： | 1 |
| 15 | Gonadotropin-relea sing hormone antagonists increase follicular fluid insulin-like growth factor-Ⅰ and vascular endothelial growth factor during ovarian stimulation cycles显示文摘 | Ferrari B Pezzuto A Barusi L | 2006 | Gynecol Endocrinol2006，22，6： | 1 |
| 16 | A lunar density model consistent with topographic,gravitational,librational,and seismic data显示文摘 | Bills B G Ferrari A J | 1977 | Journal of Geophysical Research1977，82，： | 1 |
| 17 | Parietal lobe: from action organization to intention understanding显示文摘 | Fogassi L Ferrari P F Gesierich B | 2005 | Science2005，308，： | 1 |
| 18 | Bonding regimes of nitrogen in amorphous carbon显示文摘 | KIEINSORGE B FERRARI A C Robertson J | 2000 | Diamond and Related Materials2000，9，3： | 1 |
| 19 | XML Security显示文摘 | Bertino E Carminati B Ferrari E | 2001 | Information Security Technical Report2001，6，2： | 1 |
| 20 | Diagnosis of central precocious puberty:endocrine assessment显示文摘 | Iughetti L Predieri B Ferrari M | 2000 | J Pediatr Endocrinol Metab2000，13，1： | 1 |
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