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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Hepatitis B virus immunopathogenesis显示文摘 | Chisari F V Ferrari C | 1995 | Ann Rev Immuol1995，13，： | 2 |
| 3 | Hepatitis B Virus immunopathogenesis 显示文摘 | Chisari F Ferrari C | 1995 | Annu Rev Immuol1995，13，3： | 1 |
| 4 | Effect of two etching times on the sealing ability of Clearfil Liner Bond 2 in Class V restorations 显示文摘 | Ferrari M Mannocci F Vichi A | 1997 | Am J Dent1997，10，： | 1 |
| 5 | Numerical simulation of flow interference be-tween two circular cylinders in tandem and side-by-side arrangements显示文摘 | Meneghini J R Saltara F Siqueira C L R Ferrari J A | 2001 | Journal of Fluids and Struc-tures2001，15，2： | 1 |
| 6 | Surface roughness analysis of fiber post conditioning processes 显示文摘 | Mazzitelli C Ferrari M Toledano M Osorio E Monticelli F Osorio R | 2008 | J Dent Res2008，87，2： | 1 |
| 7 | Do procalcitonin algorithms modify mortality显示文摘 | Ferrari L Casella F Podda GM | | 0，，02： | 1 |
| 8 | High occurrence rate of glaucoma among patients with Alzheimer' s disease显示文摘 | Bayer AU Ferrari F Erb C | 2002 | Eur Neurol2002，47，3： | 1 |
| 9 | A web-based distributed virtual educational laboratory显示文摘 | Benetazzo L Bertocco M Ferraris F | 2000 | IEEE Transaction on Instrumentation and Measurement2000，49，2： | 1 |
| 10 | In vitro characterization of coevaporates containing chitosan for colonic drug delivery 显示文摘 | Ferrari P C Oliveira G F Chibebe F C S | 2009 | Carbo Polym2009，78，： | 1 |
| 11 | Sol-gel derived hydroxyapatite coatings on titanium substrate显示文摘 | Montenero A Gnappi G Ferrari F | 2000 | Journal of Materials Science2000，35，11： | 1 |
| 12 | Unusual case of leiomyoma of the spermatic cord studied with ultrasonography 显示文摘 | Battaglia F Ferrari G Minzoni S | 1996 | Radiol Med1996，92，4： | 1 |
| 13 | Flavonoids and isoflavonoids from Zollernia paraensis显示文摘 | Ferrari F Botta B de Lima RA | 1983 | Phytochemistry1983，22，7： | 1 |
| 14 | Variability of interactions between neuroendocrine and immunological functions in physiological aging and dementia of the Alzheimer's type显示文摘 | Ferrari E Fioravanti M Magri F | 2000 | Ann N Y Acad Sci2000，917，： | 1 |
| 15 | General movements in full - term infants with perinatal asphyxia are related to Basal Gan- glia and thalamic lesions 显示文摘 | Ferrari F Todeschini A Guidotti I | 2011 | J Pediatr2011，158，6： | 1 |
| 16 | Cyclic ADP- ribose -mediated expansion and stimulation of human mesenchymal stem cells by the plant hormone abscisic acid 显示文摘 | SCARFI S FERRARIS C FRUSCIONE F | 2008 | Stem Cells2008，26，11： | 1 |
| 17 | Chitosan -pectin multiparticulate systems associated with enteric polymers for colonic drug delivery显示文摘 | Oliveira G F Ferrari P C Carvalho L Q | 2010 | Carbo Polym2010，82，： | 1 |
| 18 | Liquid-phase hot-pressing and WC-partide reinforcement of SiC-Si composites显示文摘 | Zhang B-R Marino F Ferraris M | 1994 | Journal of the European Ceramic Society1994，14，： | 1 |
| 19 | Study of the microstructure of o/w creams with thermal and theological methods 显示文摘 | K6nya M Sorrenti M Ferrari F | 2003 | J Therm Anal Calorim2003，73，2： | 1 |
| 20 | A murine model of muscle training by neuromuscular electrical stimulation显示文摘 | Ambrosio F Fitzgerald GK Ferrari R | 2012 | J Vis Exp2012，9，63： | 1 |
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