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| 1 | Damage-associated molecular patterns in inflammatory bowel disease:From biomarkers to therapeutic targets显示文摘The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune events represent only one of the constituents contributing to IBD pathogenesis within the context of the complex cellular and molecular network underlying chronic intestinal inflammation. These factors need to be appreciated within the milieu of nonimmune components. Damage-associated molecular patterns (DAMPs), which are essentially endogenous stress proteins expressed or released as a result of cell or tissue damage, have been shown to act as direct proinflammatory mediators. Excessive or persistent signalling mediated by such molecules can underlie several chronic inflammatory disorders, including IBD. The release of endogenous DAMPs amplifies the inflammatory response driven by immune and non-immune cells and promotes epigenetic reprogramming in IBD.The effects determine pathologic changes,which may sustain chronic intestinal inflammation and also underlie specific disease phenotypes.In addition to highlighting the potential use of DAMPs such as calprotectin as biomarkers,research on DAMPs may reveal novel mechanistic associations in IBD pathogenesis and is expected to uncover putative therapeutic targets. | Hayandra Ferreira Nanini Claudio Bernardazzi Fernando Castro Heitor Siffert Pereira de Souza | 2018 | World Journal of Gastroenterology2018，24，41： | 7 |
| 2 | Body mass index and colon cancer screening:The road ahead显示文摘Screening for colorectal cancer(CRC) has been associated with a decreased incidence and mortality from CRC.However,patient adherence to screening is less than desirable and resources are limited even indeveloped countries.Better identification of individuals at a higher risk could result in improved screening efforts.Over the past few years,formulas have been developed to predict the likelihood of developing advanced colonic neoplasia in susceptible individuals but have yet to be utilized in mass screening practices.These models use a number of clinical factors that have been associated with colonic neoplasia including the body mass index(BMI).Advances in our understanding of the mechanisms by which obesity contributes to colonic neoplasia as well as clinical studies on this subject have proven the association between BMI and colonic neoplasia.However,there are still controversies on this subject as some studies have arrived at different conclusions on the influence of BMI by gender.Future studies should aim at resolving these discrepancies in order to improve the efficiency of screening strategies. | Kanwarpreet Tandon Mohamad Imam Bahaa Eldeen Senousy Ismail Fernando Castro | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 3 | Crohn's disease presenting as acute gastrointestinal hemorrhage显示文摘Severe gastrointestinal(GI) hemorrhage is a rare complication of Crohn's disease(CD). Although several surgical and non-surgical approaches have been described over the last 2 decades this complication still poses significant diagnostic and therapeutic challenges. Given the relative infrequency of severe bleeding in CD, available medical literature on this topic is mostly in the form of retrospective case series and reports. In this article we review the risk factors, diagnostic modalities and treatment options for the management of CD presenting as GI hemorrhage. | Amareshwar Podugu Kanwarpreet Tandon Fernando J Castro | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 4 | Role of high definition colonoscopy in colorectal adenomatous polyp detection显示文摘AIM:To investigate the rates of polyp detection in a mixed risk population using standard definition (SDC) vs high definition colonoscopes (HDC).METHODS:This was a retrospective cohort comparative study of 3 colonoscopists who each consecutively performed 150 SDC (307,200 pixel) and 150 HDC (792,576 pixels) in a community teaching hospital.RESULTS:A total of 900 colonoscopies were evaluated (mean age 56,46.8% men),450 with each resolution.Polyps of any type were detected in 46.0% of patients using SDC and 43.3% with HDC (P=0.42).There was no significant difference between the overall number of polyps,HDC (397) and SDC (410),detected among all patients examined,(P=0.73).One or more adenomatous polyps were detected in 24.2% of patients with HDC and 24.9% of patients with SDC colonoscopy (P=0.82).There was no significant difference between HDC (M=0.41) and SDC (M=0.42) regarding adenomatous polyp (P=0.88) or advanced adenoma (P=0.56) detection rate among all patients examined.CONCLUSION:HDC did not improve yield of adenomatous polyp,advanced adenoma or overall polyp detection in a population of individuals with mixed risk for colorectal cancer. | Tolga Erim John M Rivas Evelio Velis Fernando Castro | 2011 | World Journal of Gastroenterology2011，17，35： | 2 |
| 5 | Learning and Optimization Using the Clone Selection Principle显示文摘 | Leandro N De Castro Fernando J Von Zuben | 2002 | lEE Transactions on Evolutionary Computation Special Issue one Artificial Immune Suystems2002，6，3： | 1 |
| 6 | Learning and optimization using clonal selection principle显示文摘 | LEANDRO Nunes de Castro FERNANDO J Von Zuben | 2001 | IEEE Transactions on Evolutionary Computation Special Issue on Artificial Immune Systems2001，6，3： | 1 |
| 7 | Learning and optimization using the clonal selection principle显示文摘 | Leandro N de Castro Fernando J Von Zuben | 2002 | IEEE Trans on Evolutionary Computation Special Issue on Artificial Immune Systems2002，6，3： | 1 |
| 8 | Learning and optimization using the clonal selection principle显示文摘 | Leandro V De Castro Fernando J Vun Zuben | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 9 | Learning and optimization using the clonal selection principle显示文摘 | Leandro N de Castro Fernando J Von Zuben | 2002 | IEEE Transactions on Evolutionary Computation2002，6，： | 1 |
| 10 | Learning and optimization using the clonal selection principle 显示文摘 | Leandro N de Castro Fernando J Von Zuben | 2002 | IEEE Transactions on Evolutionary Compution2002，6，3： | 1 |
| 11 | Kinetics of thermal de-chlorination of PVC under pyrolytic conditions显示文摘 | Alexandra Castro Delfim Soares Candida Vilarinho Fernando Castro | 2012 | Waste Management2012，，： | 1 |
| 12 | Learning and Optimization Using the Clonal Selection Principle显示文摘 | Leandro N de Castro Fernando J V Z | 2002 | IEEE Transaction On Evolution Computation2002，6，3： | 1 |
| 13 | Relevance of insulin-like growth factor 1 receptor gene expression as a prognostic factor in non-small-cell lung cancer显示文摘 | M. Teresa Agulló-Ortu?o C. Vanesa Díaz-García Alba Agudo-López Carlos Pérez Ana Cortijo Luis Paz-Ares Fernando López-Ríos Francisco Pozo Javier de Castro Hernán Cortés-Funes José A. López Martín | 2015 | Journal of Cancer Research and Clinical Oncology2015，，： | 1 |
| 14 | Multi-conductor Line Models for Harmonic Load-flow Calculations in LV Networks with High Penetration of PV Generation显示文摘Low-voltage(LV) distribution networks are unbalanced and present loads with nonlinear behavior, which introduce harmonics in the networks. The predictable increase in photovoltaic microgeneration(PV μG) accentuates this unbalanced characteristic, as well as poses new technical problems,namely voltage rise and reverse power flow. To accurately account for the distributed PV and loads in the LV network, unbalanced three-phase power flow algorithms should be utilized,where different approaches may be used to represent lines with various degrees of accuracy. The more accurate algorithm considers the electromagnetic coupling between the line conductors,whereas the simpler algorithm represents each conductor of the line as a single-phase line with pure resistive behavior. This paper aims to analyze the influence of the line model on the load flow in a highly unbalanced LV network with a high penetration of PV production, and considers the impact of the harmonics produced by nonlinear loads. Based on the results obtained,it is possible to identify the most suitable model to be used, depending on the study to be performed. Different scenarios of PV generation and loads are addressed in this paper. | Fernando M.Camilo M.E.Almeida Rui Castro V.Fernao Pires | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 1 |
| 15 | A regulatory instead of an IL-17 T response predominates in Helicobacter pylori -associated gastritis in children显示文摘 | Fabrício Freire de Melo Andreia Maria Camargos Rocha Gifone Aguiar Rocha Silvia Helena Sousa Pietra Pedroso Sérgio de Assis Batista Lúcia Porto Fonseca de Castro Simone Diniz Carvalho Paulo Fernando Souto Bittencourt Celso Afonso de Oliveira Rodrigo Corrê | 2011 | Microbes and Infection2011，，4： | 1 |
| 16 | Comparison of adenoma detection rate in Hispanics and whites undergoing first screening colonoscopy: a retrospective chart review显示文摘 | Matthew N. Thoma Brenda G. Jimenez Cantisano Adrian V. Hernandez Alejandro Perez Fernando Castro | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 17 | Leaming and Optimization Using the Clonal Selection Principle显示文摘 | Leandro N de Castro Fernando J Von Zuben | 2002 | IEEE Transactions on Evolutionary Computation Special Issue on Artificial Immune Systems2002，6，3： | 1 |
| 18 | A randomized study comparing lamivudine monotherapy after a short course of hepatitis B immune globulin (HBIg) and lamivudine with long-term lamivudine plus HBIg in the prevention of hepatitis B virus recurrence after liver transplantation显示文摘 | Mar??a Buti Antoni Mas Mart??n Prieto Fernando Casafont Antonio González Manuel Miras Jose-Ignacio Herrero Rossendo Jard?? Eva Cruz de Castro César Garc??a-Rey | 2003 | Journal of Hepatology2003，，6： | 1 |
| 19 | Learning and optimization using the clonal selection principle 显示文摘 | Leandro N de Castro Fernando J Von Zuben | 2002 | IEEE Trans on Evolutionary Computation2002，6，3： | 1 |
| 20 | Learning and optimization using clonal selection principle 显示文摘 | CASTRO L D FERNANDO J ZUBEN V | 2001 | IEEE Transactions on Evolution- ary Computation Special Issue on Artificial Immune Systems2001，6，3： | 1 |
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