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| 1 | Precut sphincterotomy:A reliable salvage for difficult biliary cannulation显示文摘Even experienced endoscopists have 90% success in achieving deep biliary cannulation with standard methods. Biliary cannulation may become difficult in 10%-15% of patients with biliary obstruction and pre- cut (access) sphincterotomy is frequently chosen as a rescue treatment in these cases. Generally, precut sphincterotomy ensures a rate of 90%-100% success- ful deep biliary cannulation. The precut technique has been performed as either a fistulotomy with a needle knife sphincterotome or as a transpapillary septotomy with a standard sphincterotome. Both methods have similar efficacy and complication rates when adminis- tered to the proper patient. Although precut sphincter- otomy ensures over 90% success of biliary cannula- tion, it has been characterized as an independent risk factor for pancreatitis. The complications of the precut technique are not limited to pancreatitis. Two more important ones, bleeding and perforation, are also re- ported in some publications as being observed more commonly than during standard sphincterotomy. It is also reported that precut sphincterotomy increases morbidity when performed in patients without dilata- tion of their biliary tract. Nevertheless, precut sphinc- terotomy is a good alternative as a rescue method in the setting of a failed standard cannulation method. This paper discusses the technical details, timing, ef- ficacy and potential complications of precut sphincter- otomy. | Ulku Saritas Yucel Ustundag Ferda Harmandar | 2013 | World Journal of Gastroenterology2013，19，1： | 13 |
| 2 | Keratinocyte 生长 factor-2 和自体同源的浆液加强处于在老鼠的角膜损坏的间充质的干细胞的再生效果显示文摘AIM:To investigate the healing process after severe corneal epithelial damage in rats treated with mesenchymal stem cells(MSCs)cultured with or without keratinocyte growth factor(KGF-2)and autologous serum(AS)on amniotic membrane(AM).Many patients are blind and devastated by severe ocular surface diseases due to limbal stem cell deficiency.Bone marrow-derived MSCs are potential sources for cellbased tissue engineering to repair or replace the corneal tissue,having the potential to differentiate to epithelial cells.METHODS:The study included 5 groups each including 10 female'Sprague Dawley'rats in addition to20 male rats used as bone marrow donors.Group I rats received AM+MSCs,Group II rats AM+MSCs cultured with KGF-2,Group III rats AM+MSCs cultured with KGF-2+AS,Group IV rats only AM and Group V rats,none.AS was derived from blood drawn from male rats and bone marrow was obtained from the femur and tibia bones of the same animals.Therapeutic effect was evaluated with clinical,histopathological and immunohistochemical assessment.MSC engraftment was demonstrated via detection of donor genotype(Y+)in the recipient tissue(X)with polymerase chain reaction.RESULTS:Corneal healing was significantly better in Groups I-III rats treated with MSC transplantation compared to Group IV and Group V rats with supportive treatment only.The best results were obtained in Group III rats with 90%transparency,70%lack of neovascularization,and 100%epithelium damage limited to less than 1/4 of cornea.CONCLUSION:We suggest that culture of MSCs with KGF-2 and AS on AM is effective in corneal repair in case of irreversible damage to limbal stem cells. | Ferda Alpaslan Pinarli Gülsen Okten Umit Beden Tunc Fisgin Mehmet Kefeli Nurten Kara Feride Duru Leman Tomak | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 3 | Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients显示文摘瞄准:为了两个都调查胃的癌症的风险是否与 Ile/Val 被联系,挑选人的表皮的生长因素 receptor-2 (HER-2 ) 的核苷酸多型性(SNP ) 在 655 上的鳕鱼和在在一个土耳其语的病人的胃的癌症案例中的 HER-2 表示的建议存在的编码域的区域组织的 transmembrane。方法:限制跟随的聚合酶链反应(PCR ) 碎裂长度多型性(RFLP ) 策略被用来在 655 上在鳕鱼分析 HER-2 SNP 的存在。c-erbB-2 表示模式被免疫组织化学分析。结果在胃的癌组和长期的胃炎组之间,以及在 clinicopathological 参数和癌之间被比较。结果:结果证明 Ile/Val 遗传型在长期的胃炎组在土耳其语的胃的癌组,和没有以内占了 20% ,并且这 genotyping 与阶段 IV 胃的癌症(P=0.04 ) 被联系。在另一方面,积极膜的 HER-2 免疫反应从长期的胃炎盒子在土耳其语的胃的癌组和没有以内占了 24% ;进一步,它与肠的类型癌(P=0.007 ) 被相关,并且上演 III-IV 癌(P=0.004 ) 。结论:这些观察暗示测试 HER-2 SNP 可以参予胃的癌症的发展和前进。在与大样品组一起证实这些结果以后,因此,在表示上的 655 SNP 或 c-erbB-2 上的 HER-2 鳕鱼可以也为胃的癌被用作差的预示的指示物。 | N Lale Satiroglu-Tufan Ferda Bir Nese Calli-Demirkan | 2006 | World Journal of Gastroenterology2006，12，20： | 4 |
| 4 | 一名无精症和开咬合畸形男性体内的额外标记染色体15显示文摘额外标记染色体15(sSMC[15])是最常见的标记染色体,通常认为如果不包含Prader-Willi/Angelman综合症关键区(Prader-Willi/Angelman syndrome critical region,PWACR),这一标记染色体就无关紧要。较大标记的关键区域的临床意义在几乎所有与标记染色体15相关的报告中都被提及,较小的标记仅与轻微畸形、无精症、习惯性流产相关。然而,这些不包含PWACR的小额外标记染色体15也可能决定某一基因表现型。我们在一个遗传学门诊对一名无精症病人进行畸形检查,根据标准的细胞遗传学方法进行外周血淋巴染色体分析,还对Y染色体微缺失进行了核仁组织区(NOR)连接、C-连接、荧光原位杂交(Fluorescence in situ hybridization,FISH)以及分子学研究。临床评估确定为畸形特征伴有无精症及重度“安氏Ⅱ类1分类开咬合畸形”。分子细胞遗传结果显示有小额外标记染色体15存在,此外,Y染色体微缺失分析显示无精症不是Y染色体微缺失的结果。额外标记染色体15和下颌不规则的症状同时出现在这一病例中,这可能只是巧合,但也可能标明了一个不仅只是无精症的特定表现型,其特征包括不育、颧骨发育不全、下颌不规则、瘢痕瘤形成以及轻微畸形特征。 | Altug Koc Odul Onur Mehmet Ali Ergun E. Ferda Pergin | 2009 | Asian Journal of Andrology2009，11，5： | 4 |
| 5 | The effect on wound healing of pazopanib and bevacizumab compared with corticosteroid in experimental glaucoma filtration surgery显示文摘AIM: To compare the effects of bevacizumab and pazopanib with corticosteroids on wound healing after trabeculectomy. METHODS: In the study, 35 New Zealand white rabbits were randomly divided into five groups. Apart from the first group, limbus-based trabeculectomy was performed for the eyes of rabbits. No postoperative treatment was administered for group Ⅰ. Topically administered saline, prednisolone acetate(1%), bevacizumab 5 mg/mL, pazopanib 5 mg/mL for group Ⅱ, Ⅲ, Ⅳ and Ⅴ respectively were applied for groups 6 h daily for 28 d. On day 28 of the experiment, eyes were enucleated and histologically and immunohistochemically analyzed.RESULTS: The fibroblast counts of groups Ⅳ and Ⅴ were determined to be lower than those of groups Ⅱ and Ⅲ(P<0.05). In the mononuclear cell(MNC) count evaluation, no statistically significant difference was determined between the treatment groups(P>0.05). The immunohistochemical staining intensity of fibroblast growth factor β(FGF-β) and vascular endothelial growth factor(VEGF) was determined to be lower in groups Ⅳ and Ⅴ than in groups Ⅱ and Ⅲ(P<0.05). No statistically significant difference was determined between groups Ⅳ and Ⅴ in respect of fibroblast count, MNC count, FGF-β and VEGF staining intensity(P>0.05). The platelet derived growth factor β(PDGF-β) intensity was lower in group Ⅴ than in groups Ⅱ, Ⅲ and Ⅳ(P<0.05). While the PDGF-β staining intensity was significantly lower in group Ⅳ thanin group Ⅱ, the difference compared with group Ⅲ was not statistically significant(P>0.05). CONCLUSION: Bevacizumab and pazopanib might be good alternatives of corticosteroid treatment on delaying wound healing in glaucoma surgery. | Sabiha Gungor Kobat Fatma Ulku Celiker Adile Ferda Dagli Kader Kasar | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 2 |
| 6 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 7 | Gastrointestinal stromal tumor of the pancreas: case report with documentation of KIT gene mutation显示文摘 | Ondrej Daum Jiri Klecka Jiri Ferda Vladimir Treska Tomas Vanecek Radek Sima Petr Mukensnabl Michal Michal | 2005 | Virchows Archiv2005，，4： | 2 |
| 8 | Protective effects of Rutin against methanol induced acute toxic optic neuropathy:an experimental study显示文摘AIM:To determine the effects of Rutin on methanol induced optic neuropathy and compare the results with the effects of ethanol.METHODS:Totally 30 rats were divided into 5 groups,with 6 rats in each group as follows:healthy controls(C),methotrexate(MTX),methotrexate+methanol(MTM),methotrexate+methanol+ethanol(MTME) and methotrexate+ methanol+Rutin(MTMR).In all rabbits except those of the control group,MTX,diluted in sterile serum physiologic,0.3 mg/kg per oral was applied for 7 d by the aid of a tube.After this procedure to the rats of MTM,MTME and MTMR groups,20% methanol with a dose of 3 g/kg per oral was given by the aid of a tube.In MTME group,4 h after the application of methanol,20% ethanol was applied by the same way with a dose of 0.5 g/kg.On the other hand,in MTMR group 4 h after the application of methanol,Rutin,which was dissolved in distilled water,was applied by the same way with a dose of 50 mg/kg.RESULTS:There were statistically significant differences in tissue 8-hydroxy-2 deoxyguanine(8-OHdG),interleukin-1β(IL-1β),tumor necrosis factor-alpha(TNF-α),malondialdehyde(MDA),myeloperoxidase(MPO).glutathione peroxidase(t GSH) and superoxide dismutase(SOD) levels between groups(P<0.001).In MTMR group tissue 8-OHdG,IL-1β,MDA,and MPO levels were similar with the healthy controls but significantly different than the other groups.In histopathological evaluations,in MTX group there was moderate focal destruction,hemorrhage and decrease innumber of astrocytes and oligodendrocytes;in MTM group there was severe destruction and edema with decrease in number of astrocytes and oligodendrocytes;in MTME group there was mild hemorrhage,mild edema,mildly dilated blood vessels with congestion while in MTMR group,optic nerve tissue was resembling the healthy controls.CONCLUSION:Rutin may prevent methanol-induced optic neuropathy via anti-inflammatory effects and decreasing the oxidative stress.New treatment options are warranted in this disease to avoid loss of vision in patients. | Nurdan Gamze Tasli Ferda Keskin Cimen Yücel Karakurt Turgay Ucak Renad Mammadov Bahadir Suleyman Nezahat Kurt Halis Suleyman | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 9 | Gastrointestinal stromal tumor of the pancreas: case report with documentation of KIT gene mutation显示文摘 | Ondrej Daum Jiri Klecka Jiri Ferda Vladimir Treska Tomas Vanecek Radek Sima Petr Mukensnabl Michal Michal | 2005 | Virchows Archiv2005，，4： | 1 |
| 10 | Resveratrol and Adipose-derived Mesenchymal Stem Cells Are Effective in the Prevention and Treatment of Doxorubicin Cardiotoxicity in Rats显示文摘 | Ferda Alpaslan P?narl? Nilüfer N. Turan Faruk Gü?lü P?narl? Arzu Okur Devrim S?nmez Tulga Ulus Aynur O?uz Ceyda Karadeniz Tuncay Deliba?? | 2013 | Pediatric Hematology-Oncology2013，，3： | 1 |
| 11 | Fever of unknown origin :A value of (18)F-FDG-PET/CT with integrated full diagnostic isotropic CT imaging 显示文摘 | FERDA J FERDOVa E ZaHLAVA J | 2009 | Eur J Radiol2009，5，： | 1 |
| 12 | molecular epi- demiology of extended-spectrum 13-lactamases among Eschefichia coli isolates collected in a Swedish Hospital and its associated health care facilities from 2001 to 2006显示文摘 | Hong Fang Ferda Ataker Goran Hedin | 2008 | Jourmal of Clinical Mi-erobiology2008，46，2： | 1 |
| 13 | A kinetic model for actinorhodin production by Streptomyces coelicolor A3(2)显示文摘 | MURAT E FERDA M | 1999 | Process Biochemistry1999，34，： | 1 |
| 14 | A dynamic study of income, energy and exports in Turkey显示文摘 | Ferda H | 2011 | Energy2011，36，5： | 1 |
| 15 | Might there be a link between mannosc-binding lectin poly- morphism and dental caries 显示文摘 | Mustafa Pehlivan Sacide Pehlivan Ferda Ozkinay | 2005 | Molecular Immunology2005，42，： | 1 |
| 16 | Correlations of serum prolidase activity between bone turnover markers and mineral density in postmenopausal osteoporosis显示文摘 | Fatma Ferda Verit Iclal Geyikli Pelin Yazgan Ahmet Celik | 2006 | Archives of Gynecology and Obstetrics2006，，3： | 1 |
| 17 | Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism显示文摘 | Oktay B Ferda B Tuba T | 2014 | Endocrine2014，45，2： | 1 |
| 18 | Assessment of grading in newly-diagnosed glioma using 18F-fluorothymidine PET/CT显示文摘 | Ferdovd E Ferda J Baxa J | 2015 | Antican-cer Res2015，35，2： | 1 |
| 19 | SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer显示文摘Pancreatic cancer has a considerably poor prognosis with a 5-year survival probability of less than 5%when all stages are combined.Pancreatic cancer is characterized by its dense stroma,which is involved in the critical interplay with the tumor cells throughout tumor progression and furthermore,creates a barrier restricting efficient penetration of therapeutics.Alterations in a large number of genes are reflected by a limited number of signaling pathways,which are potential targets.Understanding more about the molecular basis of this devastating cancer type regarding tumor microenvironment,distinct subpopulations of cells,epithelial-to-mesenchymal transition and inflammation will lead to the development of various targeted therapies for controlling tumor growth and metastasis.In this complex scenario of pancreatic cancer,especially members of the'small integrin binding ligand N-linked glycoproteins'(SIBLINGs)and'secreted protein acidic and rich in cysteine'(SPARC)families have emerged due to their prominent roles in properties including proliferation,dif-ferentiation,apoptosis,adhesion,migration,angiogenesis,wound repair and regulation of extracellular matrix remodeling.SIBLINGs consist of five members,which include osteopontin(OPN),bone sialoprotein,dentin matrix protein 1,dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein.The SPARC family of modular extracellular proteins is comprised of SPARC/osteonectin(ON)and SPARC-like 1(hevin);secreted modular calcium binding proteins;testicans and follistatin-like protein.In this review,we especially focus on OPN and ON,elaborating on their special and growing importance in pancreatic cancer diagnosis and prognosis. | Ferda Kaleagasioglu Martin R Berger | 2014 | World Journal of Gastroenterology2014，20，40： | 1 |
| 20 | Effect of dietary probiotic, organic acid and antibiotic supplementation to diets en broiler performance and carcasss yield 显示文摘 | Muzaffer Denli Ferda Okan Kemal Celik | 2003 | Pakistan Joural of Nutriation2003，2，： | 1 |
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