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| 1 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 2 | Successive inverse and normal magnetocaloric effects in the Mn-vacancy compound Mn0.95Co0.75Cu0.25Ge显示文摘Ferromagnetic-structural transformation has been studied widely in MnCoGe-based materials. However, the magnetostructural transition(MST) from antiferromagnetic(AFM) orthorhombic phase to ferromagnetic(FM) hexagonal phase, which may lead to a large inverse magnetocaloric effect(MCE), has rarely been reported. Here, the introduction of Mn vacancy lowers the structural transition temperature while retains the AFM state in the orthorhombic phase, thus successfully realizing the AFM-FM MST in Mn0.95Co0.75Cu0.25Ge. Moreover, successive inverse and normal MCEs are observed around the first-order AFM-FM MST and the second-order FM-paramagnetic(PM) transition, respectively. A thermostat is proposed based on this special feature, which could release heat above the critical temperature while absorb heat below the critical temperature by simply applying the same magnetization/demagnetization cycles. This thermostat can be very useful in many applications where a constant temperature is required, such as cryostats and incubators. | FengXia Liu Hu Zhang He Zhou DaoYong Cong RongJin Huang LiChen Wang Yi Long | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 9 |
| 3 | Effects of interstitial H and/or C atoms on the magnetic and magnetocaloric properties of La(Fe, Si)_(13)-based compounds显示文摘La(Fe,Si)13-based compounds have been considered as promising candidates for magnetic refrigerants particularly near room temperature.Herein we review recent progress particularly in the study of the effects of interstitial H and/or C atoms on the magnetic and magnetocaloric properties of La(Fe,Si)13compounds.By introducing H and/or C atoms,the Curie temperature TC increases notably with the increase of lattice expansion which makes the Fe 3d band narrow and reduces the overlap of the Fe 3d wave functions.The first-order itinerant-electron metamagnetic transition is conserved and the MCE still remains high after hydrogen absorption.In contrast,the characteristic of magnetic transition varies from first-order to second-order with the increase of C concentration,which leads to remarkable reduction of thermal and magnetic hysteresis.In addition,the introduction of interstitial C atoms promotes the formation of NaZn13-type(1:13)phase in La(Fe,Si)13compounds,and thus reducing the annealing time significantly from 40 days for LaFe11.7Si1.3to a week for LaFe11.7Si1.3C0.2.The pre-occupied interstitial C atoms may depress the rate of hydrogen absorption and release,which is favorable to the accurate control of hydrogen content.It is found that the reduction of particle size would greatly depress the hysteresis loss and improve the hydrogenation process.By the incorporation of both H and C atoms,large MCE without hysteresis loss can be obtained in La(Fe,Si)13compounds around room temperature,for instance,La0.7Pr0.3Fe11.5Si1.5C0.2H1.2exhibits a large|SM|of 22.1 J/(kg·K)at TC=321 K without hysteresis loss for a field change of 0 5 T. | ZHANG Hu HU FengXia SUN JiRong SHEN BaoGen | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 6 |
| 4 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 5 | Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers显示文摘Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers. | Jiali Hu Ke Li Zhanghuan Li Chao Gao Fei Guo Yingmei Wang Fengxia Xue | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 6 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 7 | Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals显示文摘The global Coronavirus disease 2019(COVID-19)pandemic caused by SARS-CoV-2 has affected more than eight million people.There is an urgent need to investigate how the adaptive immunity is established in COVID-19 patients.In this study,we proled adaptive immune cells of PBMCs from recovered COVID-19 patients with varying disease severity using single-cell RNA and TCR/BCR V(D)J sequencing.The sequencing data revealed SARS-CoV-2-specic shufing of adaptive immune repertories and COVID-19-induced remodeling of peripheral lymphocytes.Characterization of variations in the peripheral T and B cells from the COVID-19 patients revealed a positive correlation of humoral immune response and T-cell immune memory with disease severity.Sequencing and functional data revealed SARS-CoV-2-specic T-cell immune memory in the convalescent COVID-19 patients.Furthermore,we also identied novel antigens that are responsive in the convalescent patients.Altogether,our study reveals adaptive immune repertories underlying pathogenesis and recovery in severe versus mild COVID-19 patients,providing valuable information for potential vaccine and therapeutic development against SARS-CoV-2 infection. | Fan Zhang Rui Gan Ziqi Zhen Xiaoli Hu Xiang Li Fengxia Zhou Ying Liu Chuangeng Chen Shuangyu Xie Bailing Zhang Xiaoke Wu Zhiwei Huang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 8 | Feasibility of Intermediate Fluid Vaporizer with Spiral Wound Tubes显示文摘A novel intermediate fluid vaporization (IFV) technology for LNG re-gasification process with spiral-wound heat exchanging tubes is proposed. The new IFV project combines the advantage of running the shell and tube heat exchangers at high pressure with the advantage of compact space of heat exchangers. Thermal analysis on the two processes of forced convection and vaporization type heat transfer in the spiral wound tubes and vapor condensation /re-boiling type of heat transfer via intermediate fluid in shell side shows the feasibility of this promising technology. | Liu Fengxia Dai Yuqiang Wei Wei Zou Jiupeng Zhu Che Dong Chao Hu Dapeng | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 2 |
| 9 | 显示文摘 | Hu Fengxia Shen Baogen Sun Jirong | 2000 | Appl Phys Lett2000，76，： | 1 |
| 10 | 显示文摘 | Hu Fengxia Shen Baogen sun jirong | 2001 | Appl Phys Lett2001，78，23： | 1 |
| 11 | 显示文摘 | Hu Fengxia Shen Baogen | 2000 | Appl Phys Lett2000，80，5： | 1 |
| 12 | 显示文摘 | Hu Fengxia Shen Baogen | 2000 | J Phys: Condens Matter2000，12，： | 1 |
| 13 | 显示文摘 | Hu Fengxia Shen Baogen | 2001 | Physical Review B2001，64，： | 1 |
| 14 | 显示文摘 | Wang Guangjun Hu Fengxia Wang Fang | 2004 | Chinese Physics2004，13，4： | 1 |
| 15 | 显示文摘 | Hu Fengxia Shen Baogen | 2001 | Appl Phys Lett2001，78，23： | 1 |
| 16 | Mossbauer effect probe of field-induced magnetic phase transition in LaFe13-xSix intermetallic compounds 显示文摘 | Cheng Zhaohua Di Naili Li Qingan Kou Zhiqi Luo Zhi Ma Xiao Wang Guangjun Hu Fengxia Shen Baogen | 2004 | Applied Physics Letters2004，85，10： | 1 |
| 17 | Enhanced thermoelectric performance and atomic-resolution interfacial structures in BiSbTe thermo-electro-magnetic nanocomposites incorporating magnetocaloric LaFeSi nanoparticles显示文摘Incorporating magnetic nanoparticles in thermoelectric(TE)materials introduce magnetic interfaces with additional electron and phonon scattering mechanism for high TE performance.However,the influence of heterogeneous interfaces between magnetic nanoparticles and TE matrix on electronic and thermal transport remains elusive in the thermo-electric-magnetic nanocomposites.Here,using p-type TE material Bi_(0.3)Sb_(1.7)Te_(3)(BST)as matrix and magnetocaloric(MC)material La(Fe_(0.92)Co_(0.08))_(11.9)Si_(1.1)(LFS)nanoparticles as a second phase,TE/MC nanocomposites xLFS/BST(x=0.1%,0.2%,0.3% and 0.4%)were synthesized using spark plasma sintering method.The atomic-resolution interfacial structures demonstrate that Te vacancies originating from LFS-BST interfacial reaction decreases the hole concentration of the LFS/BST nanocomposites and enhances the Seebeck coefficient.The LFS/BST nanocomposites exhibit lower thermal conductivity due to enhanced phonon scattering by interfaces and defects.All the nanocomposites have higher ZT than BST matrix,with 0.2% LFS/BST nanocomposite achieving highest ZT=1.11 at 380 K.At working current 1.4 A,the device fabricated using 0.2% LFS/BST nanocomposite achieves maximal cooling temperature 4.9 K,which is 58% higher than the matrix.Moreover,the MC properties are retained in all the nanocomposites,which make them a promising candidate to achieve high TE performance and dual TE/MC properties for future applications. | Lin Xing Wenjun Cui Xiahan Sang Fengxia Hu Ping Wei Wanting Zhu Xiaolei Nie Qingjie Zhang Wenyu Zhao | 2021 | Journal of Materiomics2021，7，5： | 1 |
| 18 | 显示文摘 | Hu Fengxia | 2001 | Appl Phys Lett2001，78，23： | 1 |
| 19 | A unified thermal model of thermophysical effects with pulse width from nanosecond to femtosecond 显示文摘 | Fang Ranran Zhang Duanming Wei Hua Li Zhihua Yang Fengxia Gao Yihua Hu Dezhi Li Zhihua Tan Xinyu Sun Min Yang Fengxia | 2008 | The European Physical Journal Applied Physics2008，42，3： | 1 |
| 20 | The genetic control of glabrous glume during African rice domestication显示文摘African cultivated rice,Oryza glaberrima,is characterized by its glabrous glumes.During domestication,the pubescent glumes of its wild ancestor,Oryza barthii,lost their trichomes,and in this study,we show that glabrous glume 5(GLAG5),a WUSCHEL-like homeobox transcription factor gene on chromosome 5,is required for trichome development.DNA methylation associated with an hATtransposable element inserted in the promoter region of GLAG5 is found to reduce its expression,leading to the formation of glabrous glumes and leaves in African cultivated rice.Among 82 African cultivated rice varieties investigated in this study,59(approximately 71%)lines exhibit glabrous glumes and harbor the hAT transposon;however,the other 23 varieties(approximately 29%),which exhibit pubescent glumes,lack the hAT transposon,indicating that glag5 had undergone strong artificial selection.Theπ;/π;ratios also show the hAT transposon insertions influence the genetic diversity of an approximately 150-kb interval encompassing the GLAG5 locus.The identification of the GLAG5 gene provides new insights into the domestication of cultivated rice in Africa.We speculate that the selection of varieties with mutations in their promoter regions is an important aspect of crop domestication. | Leqin Chang Min Hu Jing Ning Wei He Jiayu Gao Marie-Noelle Ndjiondjop Yongcai Fu Fengxia Liu Hongying Sun Ping Gu Chuanqing Sun Zuofeng Zhu | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
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