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| 1 | Knockdown of S-phase Kinase-associated Protein-2 Expression in MCF-7 Inhibits Cell Growth and Enhances the Cytotoxic Effects of Epirubicin显示文摘S 阶段联系 kinase 的 protein-2 (Skp2 ) 在调停 ubiquitin 的解朊作用起一个关键作用,导致房间从的前进一对一个 proliferative 状态静止。Skp2 完了在许多肿瘤表示了并且相反地与 p27 表示相关,包括乳癌。在这研究,我们使用了小介入的 RNA (siRNAs ) 在人的乳癌 MCF-7 细胞禁止 Skp2 表示并且如果击倒,从而由 RNA 干扰(RNAi ) Skp2 调查将禁止乳癌细胞生长并且在 MCF-7 细胞上影响 epirubicin 的效果。三 Skp2 siRNA 构造被重新结合并且短暂地 transfected 人乳癌 MCF-7 房间。Skp2 的下面规定被反向的抄写聚合酶链反应和蛋白质印迹分析证实。我们证明 Skp2 siRNA 转染减少了 Skp2 蛋白质并且在 MCF-7 房间导致了 p27 蛋白质的累积。Skp2 siRNA 在 vitro 并且在 vivo 禁止了房间增长。由 RNAi 的 Skp2 击倒在 vitro 的增加的细胞的 apoptosis。有治疗进一步与 epirubicin 跟随的 Skp2 siRNA 的治疗禁止了癌症房间线的增长,与 epirubicin 跟随的控制 siRNA 相比。因此, Skp2 击倒由 RNAi 的表示禁止乳癌细胞生长并且提高 epirubicin 的效果。Skp2 的调停 siRNA 的基因 silencing 能是为在规定下面的 p27 的抑制的新奇癌症基因治疗。 | Lichun SUN Li CAI Yan YU Qingwei MENG Xuesong CHENG Yanbin ZHAO Guangjie SUI Fengmin ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 6 |
| 2 | The modern change and evolution tendency of sand coast in the eastern area of Liaodong Gulf显示文摘The modern change and evolution tendency of sand coast in the eastern area of Liaodong GulfMiaoFengmin;BiZhaoqi;LiShuyuan;Xia... | Miao Fengmin Bi Zhaoqi Li Shuyuan Xiao Yuzhong Cong Peifu Zhuang Zhenye and Xu Weidong | 1995 | Acta Oceanologica Sinica1995，14，4： | 5 |
| 3 | Allelopathic inhibition on red tide microalgae Skeletonema costatum by five macroalgal extracts显示文摘This study aims to identify effective antialgal allelochemicals from marine macroalgae that inhibit the growth of red tide microalgae.Practically,new algicidal agents were developed to control red tide.The growth inhibitory effects of 5 marine macroalgae Porphyra tenera,Laminaria japonica,Ulva pertusa,Enteromorpha clathrata,and Undaria pinnatifida on Skeletonema costatum were evaluated by adding crude seawater extracts of macroalgal dry tissue into the culture medium containing S.costatum.The half-effective concentrations at 120 h(EC_(50),120 h)of the seawater extracts were 0.6,0.9,1.0,1.0,and 4.7 g/L for the five macroalgae above,respectively.E.clathrata,L.japonica and U.pertusa showed strong allelopathic effect on the growth of S.costatum.There have been no previous reports with regard to the allelopathic effects of the former two macroalgae so far.The possible allelochemicals of 21 compounds of the E.clathrata were detected using Gas chromatography-mass spectrometry(GC-MS)analysis.Unsaturated fatty acids,acrylic acid(C_(3)H_(4)O_(2)),and linolenic acid(C_(18)H_(30)O_(2))were the most likely allelochemicals in E.clathrata. | Zhen AN Zhenyu WANG Fengmin LI Zhijia TIAN Hongying HU | 2008 | Frontiers of Environmental Science & Engineering2008，2，3： | 4 |
| 4 | Current Development Situation and Prospects of Blueberry in Guangdong Province显示文摘With high nutrition and health value,blueberry receives much concern in recent years. Blueberry experts in the world are cultivating new blueberry varieties. They have come up with constructive theoretical support and planting technology researches and are constantly devoted to expanding blueberry planting latitudes. This paper elaborated researches of blueberry at home and abroad,current development situation of blueberry in China and Guangdong Province,analyzed strengths of planting blueberry in Guangdong. Besides,it came up with recommendations for development of blueberry industry. Finally,it discussed development prospects of blueberry planting in Guangdong. | Lixia GAO Hualan XIAO Sen LI Fengmin LIU Aiqiong MO | 2015 | Asian Agricultural Research2015，7，9： | 2 |
| 5 | Adaptive projected gradient thresholding methods for constrained l0problems显示文摘In this paper, we propose and analyze adaptive projected gradient thresholding(APGT) methods for finding sparse solutions of the underdetermined linear systems with equality and box constraints. The general convergence will be demonstrated, and in addition, the bound of the number of iterations is established in some special cases. Under suitable assumptions, it is proved that any accumulation point of the sequence generated by the APGT methods is a local minimizer of the underdetermined linear system. Moreover, the APGT methods, under certain conditions, can find all s-sparse solutions for accurate measurement cases and guarantee the stability and robustness for flawed measurement cases. Numerical examples are presented to show the accordance with theoretical results in compressed sensing and verify high out-of-sample performance in index tracking. | ZHAO ZhiHua XU FengMin LI XiangYang | 2015 | Science China Mathematics2015，58，10： | 2 |
| 6 | Effect of rare earth element europium on amaranthin synthesis in Amarathus caudatus seedlings显示文摘 | Fuli Zeng Hong Er Tian Zhipeng Wang Yi An Fengyi Gao Lijing Zhang Fengmin Li Lun Shan | 2003 | Biological Trace Element Research (-)2003，，1： | 1 |
| 7 | Effects of clear plistie film mulch on yield of spring wheat显示文摘 | Li Fengmin Guo Anhong Wei Hong | 1998 | Field Crops Res1998，63，： | 1 |
| 8 | Yield perfor- mance of spring wheat improved by regulated deficit irrigation in an arid area显示文摘 | Zhang Buchong Li Fengmin Huang Gaobao | 2006 | Agricultural Water Management2006，79，： | 1 |
| 9 | Regioselective oxidation of tetracycline by permanganate through alternating susceptible moiety and increasing electron donating ability显示文摘Permanganate has attracted much attention in wide range of chemistry and particularly in degradation of environmental pollutants.However,few studies have discussed the feature of regioselective reactivity of permanganate with specific moiety of the target compound.Herein,we studied the reaction between permanganate and tetracycline that is an emerging micropollutant with different species containing several electron-rich groups.The second-order rate constants increased from 6.0 to 9.0 and could be quantitatively modeled by considering the speciation of both reactants,yielding kTC0=11.7(mol/L)^-1 sec^-1,kTC-=35.7(mol/L)^-1 sec^-1,kTC2-=43.1(mol/L)^-1 sec^-1 for individual reaction channels.Degradation products were then identified as the hydroxylated and demethylated compounds.The result suggested a rate-limiting step of simple hydroxylation at the phenolic and/or alkene moieties,while the demethylation should be caused by the unavoidably formed manganese oxide via single electron oxidation.This is supported by the DFT calculation,indicating the primary oxidation of phenolic group of TC0 with activation barrier of 44.5 kcal/mol and of alkene group of TC-and TC2-with activation barriers of 44.0 and 43.4 kcal/mol,respectively.This is in agreement with the experimental results,implying the alternation of regioselectivity associated with the deprotonation process.The result was further supported by performing the Fukui function and electrostatic potential analysis,reflecting the more probable site and better electron donating tendency beneficial to the permanganate oxidation. | Xiaohua Jiang William AJefferson Dean Song Hanyang Cheng Fengmin Li Zhimin Qiang Aiqian Zhang Huijuan Liu Jiuhui Qu | 2020 | Journal of Environmental Sciences2020，32，1： | 1 |
| 10 | Effects of clear plastic film mulch on yield of spring wheat显示文摘 | Li Fengmin Guo Anhong Wei Hong | 1999 | Field Crops Res1999，63，： | 1 |
| 11 | Semaphorin 4D expression is associated with a poor clinical outcome in cervical cancer patients显示文摘 | Huidong Liu Yanmei Yang Jianbing Xiao Shucai Yang Yan Liu Wenhui Kang Xinlei Li Fengmin Zhang | 2014 | Microvascular Research2014，，： | 1 |
| 12 | Soil physical properties and their relations to organic carbon pools as affected by land use in an alpine pastureland显示文摘 | Li Xiaogang Li Fengmin Rengel Zed | 2007 | Geoderma2007，139，： | 1 |
| 13 | Long-term fertilization effects on crop yield and nitrate nitrogen accumulation in soil in northwestern China显示文摘 | Yang Shengmao Li Fengmin Malhi S S | 2004 | Agronomy Journal2004，96，4： | 1 |
| 14 | How double ridges and furrows mulched with plastic film affect soil water, soil temperature and yield of maize on the semiarid Loess Plateau of China显示文摘 | Zhou Limin Li Fengmin Jin Shengli | 2009 | Field Crops Research2009，113，1： | 1 |
| 15 | Study of the Therapeutic Effect of Acupuncture on 1134 cases of Simple Obesity 显示文摘 | Liu Zhicheng Sun Fengmin Li Jia | 1998 | The International Journal of Acupuncture1998，2，2： | 1 |
| 16 | Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine显示文摘 | Jie Chen Zhenglun Liang Fengmin Lu Xin Fang Shuang Liu Ying Zeng Fengcai Zhu Xiangmei Chen Tao Shen Jie Li Hui Zhuang | 2010 | Vaccine2010，，4： | 1 |
| 17 | Fuzzy classification of nucleotide sequences and bacterial evolution显示文摘 | Liaofu Luo Fengmin Ji Hong Li | 1995 | Bulletin of Mathematical Biology1995，，4： | 1 |
| 18 | Effect of plastic mulching on soil water use and spring wheat yield in arid region of northwest China显示文摘 | XIE Zongkui WANG Yajun LI Fengmin | 2005 | Agricultural Water Management2005，75，： | 1 |
| 19 | Water use patterns and agronomic performance for some cropping systems with and without fallow crops in a semi-arid environment of northwest China显示文摘 | Li Fengmin Zhao Songling Geballe G T | 2000 | Agric Ecosyst Environ2000，79，23： | 1 |
| 20 | Diagnostic value of anti-cyclic citrullinated peptide antibodies in northern Chinese Han patients with rheumatoid arthritis and its correlation with disease activity显示文摘 | Li Hui Song Wuqi Li Yang Liu Yanhong Bai Jing Li Xiu Mu Fengyun Wang Yao Zhang Fengshan Su Liju Zhang Fengmin | 2010 | Clinical Rheumatology2010，，4： | 1 |
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