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| 1 | Petrogenesis and dating of the Kangding complex,Sichuan Province显示文摘An analysis of major and trace element geochemistry and SHRIMP U-Pb zircon dating of mafic, intermediate, and felsic rocks from the Mianning metamorphic complex of Si- chuan Province was conducted. One of our conclusions is that a majority of the zircons crystal- lized between 721 and 773 Ma in a magmatic regime. The complexes contain early to late Pa- leo-proterozoic relict zircons from ancient continental crust. The oldest age, 2468 Ma, may rep- resent the basement of the Yangtze block. Overgrowth zircon rims and palingenetic zircons have been observed and dated, and are believed to have formed after crystallization, during Paleozoic and Mesozoic metamorphic-anatexis. We also conclude that depletion of Nb, Ta, HREE, in a spider-diagram normalized to primitive mantle and calc-alkaline association, implies that they formed in island-arc or under-plating settings. | CHEN Yuelong 1 , LUO Zhaohua 1 , ZHAO Junxiang, LI Zhihong, ZHANG Hongfei & SONG Biao 3 1. Faculty of Earth Sciences and Natural Resources, China University of Geosciences, Beijing 100083, China 2. Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 3. Beijing SHRIMP Center, Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，5： | 40 |
| 2 | Carotenoid metabolism and regulation in horticultural crops显示文摘Carotenoids are a diverse group of pigments widely distributed in nature.The vivid yellow,orange,and red colors of many horticultural crops are attributed to the overaccumulation of carotenoids,which contribute to a critical agronomic trait for flowers and an important quality trait for fruits and vegetables.Not only do carotenoids give horticultural crops their visual appeal,they also enhance nutritional value and health benefits for humans.As a result,carotenoid research in horticultural crops has grown exponentially over the last decade.These investigations have advanced our fundamental understanding of carotenoid metabolism and regulation in plants.In this review,we provide an overview of carotenoid biosynthesis,degradation,and accumulation in horticultural crops and highlight recent achievements in our understanding of carotenoid metabolic regulation in vegetables,fruits,and flowers. | Hui Yuan Junxiang Zhang Divyashree Nageswaran Li Li | 2015 | Horticulture Research2015，2，1： | 32 |
| 3 | A step metallogenetic model for gold deposits in the northwestern Shandong Peninsula, China显示文摘Based on our study of the nature and variation of mineralization-controlling faults in their deep extension and the spatial distribution of gold orebodies in the northwestern Shandong Peninsula (NSP), here we propose that the gold deposits in the Jiaojia gold belt are controlled by listric faults and the gold deposits in the NSP are controlled by extensional fault system. We also suggest that there is a multiple mineralization space in the deep part of the NSP gold belt. As steps or benches occur along the deep extention of the listric fault where its dipping angle changes from steep to gentle, a number of gold deposits are correspondingly distributed as a steplike pattern, which is named as a step metallogenetic model for gold deposits in the NSP. The gold deposits in Shandong Peninsula were formed in the Cretaceous when the crust in the region experienced extention and thinning following the strong collision between North China Plate and Yangtze Plate during the Triassic. Crust anataxis, fluid remobilization, and extention-detachement of the crust are the leading factors for the gold mineralization. | SONG MingChun YI PiHou XU JunXiang CUI ShuXue SHEN Kun JIANG HongLi YUAN WenHua WANG HuaJiang | 2012 | Science China Earth Sciences2012，55，6： | 21 |
| 4 | The Kiloton Class Jiaojia Gold Deposit in Eastern Shandong Province and Its Genesis显示文摘当以前建议了,在东方山东省的 Jiaojia 区域的最近的深勘探结果显示 Jiaojia 矿石域几单个金沉积物创作了实际上是极端大的金沉积物。这沉积物盖住 ∼40 km 2, 的一个区域并且由 Jiaojia 差错和它的第二等的差错显示出结构的控制。金 orebodies 通常沿着一样的矿化作用改变带,和主要 orebodies 发生与对方一起交叉或展出平行或重叠的分布。这沉积物的储备被估计是 1,黄金的 200t,是超过 1000t 黄金的第一金沉积物在中国保留。没有。在页岩深的 Sizhuang 矿石块的 I-1 orebody 使金储备保持比 350 t 大,否则 29% 总数保留列在后面由没有。我在有超过 150t 黄金的 Matang-Jiaojia 矿石块的 orebody 保留。这存款主要在 Jiaojia 差错的矿脉基卒下盘发生,并且在矿化作用,改变和结构介绍 zoned 模式。强烈使矿物化的地区强烈同意改变了并且构造地断裂了地区。这些 orebodies 显示象 strataform 一样, veinlike 或透镜的形状,并且通常显示出外面拧并且重现的特征,分叉并且收敛,膨胀并且缩小。orebodies 通常与剧降变化从沿着差错罢工变化的职务并且在轻轻的地点发生对陡峭轻轻。主要 orebodies 与控制矿石的差错的主要飞机平行,并且趋于从表面轻轻到深。orebodies 主要跳入到西南,与跳入 45 °-60° 的角度。控制矿石的差错的主要飞机附近的 Orebodies 比那些有更多的金资源离开主要差错地区。orebodies 的观点深度通常比沿着它的罢工方向的长度大;orebodies 变得厚,金等级从浅区域变得低到深区域。形成矿石的液体是 H 2O 公司 2-NaCl±CH4 类型与对低咸度中等温度、中等。硫同位素的价值(δ34 S 为金矿石的 CDT ) 在 11.08 ‰ 之间变化并且 12.58 ‰ ,显示混合了硫来源;氢同位素的价值(δD 从 -83.68‰ 的 V 降雪 ) 范围到 -116.95‰并且氧同位素的价值(δ18 O 在 12.04 ‰ 之间的 V 降雪 ) 范围并且 16.28 ‰ 。氢和氧同位素建议形成矿石的液体从主要岩浆发源,并且在迟了的阶段期间与大量大气的水混合。东方山东省金存款与让 mantle-crust-mixed 采购原料的 magmatic 活动被联系,并且也与热水的黄金扔的 orgenic 和 epithermal 分享一些类似。因为东方山东省黄金与与另外的金牌不同的唯一的 metallogenic 特征和形成背景扔,沉积物录入世界,我们把它称为 Jiaojia 类型金存款。千吨班 Jiaojia 金存款与液体活动,延期和分队有关源于岩浆的热 upwelling。在到在东方山东省的早白垩纪的迟了的舞台的中间的强壮的 magmatic 活动为金 depsoits 导致活跃液体,和提供的丰富的形成矿石的材料。而且,源于外壳的扩展的许多 extensional 结构为放的 orebody 提供了赞成空间。 | SONG Mingchun DENG Jun YI Pihou YANG Liqiang CUI Shuxue XU Junxiang ZHOU Mingling HUANG Tailing SONG Guozheng SONG Yingxin | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 14 |
| 5 | Using borehole core analysis to reveal Late Quaternary paleoearthquakes along the Nankou-Sunhe Fault,Beijing显示文摘The Nankou-Sunhe Fault is a buried active normal fault that traverses the urban area of Beijing.Its seismic risks have caused considerable concerns.This paper studies paleoearthquakes along this fault by analyzing and correlating bore-hole cores obtained from triple-tube coring,incorporating experience acquired from trenching.As a result,a model for identifying earthquake-derived colluvium by sediment-core analysis is proposed.Triple-tube coring technique is useful to collect continuous undis-turbed soil core near the Nankou-Sunhe Fault.By identifying fault-scarp colluviums,determining cumulative displacement,and analysing stratum thickening on the hanging wall,we are able to establish a preliminary paleoearthquake sequence consisting of 13 surface-rupturing events since 60 ka.The seismic history can be divided into three periods based on different recurrence intervals.Between 60 and 40 ka,three earthquakes occurred with recurrence interval of ~10 ka.From 40 to 25 ka,there were six earthquakes with the recurrence interval of about 2.5 ka.In the last 25 ka,four earthquakes have taken place with the recurrence interval varying considerably.The recurrence interval between the last three events is ~5 ka.Smaller recurrence intervals correspond to stages of faster fault slip.The coseismic displacement of a single event is 0.8 to 2.2 m,average 1.4 m,largely equivalent to moment magnitudes 6.7-7.1.This study demonstrates the feasibility of bore-hole drilling in investigating paleoearthquakes along normal faults.It also suggests that closely spaced boreholes with continuous undisturbed cores are essential for reconstructing the complete paleoearthquake sequence. | ZHANG ShiMin WANG DanDan LIU XuDong ZHANG GuoHong ZHAO JunXiang LUO MingHui REN JunJie WANG Rui ZHANG YingLi | 2008 | Science China Earth Sciences2008，51，8： | 11 |
| 6 | Global Fine Registration of Point Cloud in LiDAR SLAM Based on Pose Graph显示文摘The laser scanning system based on Simultaneous Localization and Mapping(SLAM)technology has the advantages of low cost,high precision and high efficiency.It has drawn wide attention in the field of surveying and mapping in recent years.Although real-time data acquisition can be achieved using SLAM technology,the precision of the data can’t be ensured,and inconsistency exists in the acquired point cloud.In order to improve the precision of the point cloud obtained by this kind of system,this paper presents a hierarchical point cloud global optimization algorithm.Firstly,the“point-to-plane”iterative closest point(ICP)algorithm is used to match the overlapping point clouds to form constraints between the trajectories of the scanning system.Then a pose graph is constructed to optimize the trajectory.Finally,the optimized trajectory is used to refine the point cloud.The computational efficiency is improved by decomposing the optimization process into two levels,i.e.local level and global level.The experimental results show that the RMSE of the distance between the corresponding points in overlapping areas is reduced by about 50%after optimization,and the internal inconsistency is effectively eliminated. | Li YAN Jicheng DAI Junxiang TAN Hua LIU Changjun CHEN | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 9 |
| 7 | Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections:An in vitro and in vivo study显示文摘Magnesium(Mg)alloys that have both antibacterial and osteogenic properties are suitable candidates for orthopedic implants.However,the fabrication of ideal Mg implants suitable for bone repair remains challenging because it requires implants with interconnected pore structures and personalized geometric shapes.In this study,we fabricated a porous 3D-printed Mg-Nd-Zn-Zr(denoted as JDBM)implant with suitable mechanical properties using selective laser melting technology.The 3D-printed JDBM implant exhibited cytocompatibility in MC3T3-E1 and RAW267.4 cells and excellent osteoinductivity in vitro.Furthermore,the implant demonstrated excellent antibacterial ratios of 90.0% and 92.1% for methicillin-resistant S.aureus(MRSA)and Escherichia coli,respectively.The 3D-printed JDBM implant prevented MRSA-induced implant-related infection in a rabbit model and showed good in vivo biocompatibility based on the results of histological evaluation,blood tests,and Mg2+deposition detection.In addition,enhanced inflammatory response and TNF-α secretion were observed at the bone-implant interface of the 3D-printed JDBM implants during the early implantation stage.The high Mg^(2+)environment produced by the degradation of 3D-printed JDBM implants could promote M1 phenotype of macrophages(Tnf,iNOS,Ccl3,Ccl4,Ccl5,Cxcl10,and Cxcl2),and enhance the phagocytic ability of macrophages.The enhanced immunoregulatory effect generated by relatively fast Mg^(2+)release and implant degradation during the early implantation stage is a potential antibacterial mechanism of Mg-based implant.Our findings indicate that 3D-printed porous JDBM implants,having both antibacterial property and osteoinductivity,hold potential for future orthopedic applications. | Kai Xie Nanqing Wang Yu Guo Shuang Zhao Jia Tan Lei Wang Guoyuan Li Junxiang Wu Yangzi Yang Wenyu Xu Juan Chen Wenbo Jiang Penghuai Fu Yongqiang Hao | 2022 | Bioactive Materials2022，7，2： | 8 |
| 8 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 9 | Two-dimensional optical spatial differentiation and high-contrast imaging显示文摘Optical analog signal processing technology has been widely studied and applied in a variety of science and engineering fields, with the advantages of overcoming the low-speed and high-power consumption associated with its digital counterparts. Much attention has been given to emerging metasurface technology in the field of optical imaging and processing systems. Here, we demonstrate, for the first time, broadband two-dimensional spatial differentiation and high-contrast edge imaging based on a dielectric metasurface across the whole visible spectrum. This edge detection method works for both intensity and phase objects simply by inserting the metasurface into a commercial optical microscope. This highly efficient metasurface performing a basic optical differentiation operation opens up new opportunities in applications of fast,compactible and power-efficient ultrathin devices for data processing and biological imaging. | Junxiao Zhou Haoliang Qian Junxiang Zhao Min Tang Qianyi Wu Ming Lei Hailu Luo Shuangchun Wen Shaochen Chen Zhaowei Liu | 2021 | National Science Review2021，8，6： | 6 |
| 10 | Bamboo charcoal addition enhanced the nitrogen removal of anammox granular sludge with COD:Performance,physicochemical characteristics and microbial community显示文摘The effects of different chemical oxygen demand(COD)concentrations on the anammox granular sludge with Bamboo Charcoal(BC)addition were evaluated in UASB reactor.The results showed that the average total nitrogen(TN)removal efficiency was reduced from 85.9%to 81.4%when COD concentration was increased from 50 to 150 mg/L.However,the TN removal efficiency of BC addition reactors was dramatically 3.1%-6.4%higher than that without BC under different COD concentrations.The average diameter of granular sludge was 0.13 mm higher than that without BC.The settling velocity was increased by elevated COD concentration,while the EPS and VSS/SS were increased with BC addition.The high-throughput Miseq sequencing analyses revealed that the bacterial diversity and richness were decreased under COD addition,and the Planctomycetes related to anammox bacteria were Candidatus Brocadia and Candidatus Kuenenia.The Metagenomic sequencing indicated that the abundance of denitrification related functional genes all increased with elevated COD,while the abundance of anammox related functional genes of decreased.The func-tional genes related to anammox was hydrazine synthase encoding genes(hzsA,hzsB and hzsB).The average relative abundance of hzs genes in the reactor with BC addition was higher than the control at COD concentrations of 50 mg/L and 150 mg/L.The functional genes of denitrification mediated by BC were higher than those without BC throughout the operation phase.It is interesting to note that BC addition greatly enriched the related func-tional genes of denitrification and anammox. | Menglei Guo Ying Jiang Junxiang Xie Qianfei Cao Qun Zhang Adams Mabruk Chongjun Chen | 2022 | Journal of Environmental Sciences2022，34，5： | 5 |
| 11 | Dynamic leakage mechanism of gas drainage borehole and engineering application显示文摘Borehole leakage not only affects the gas drainage effect but also presents considerable risk to human security. For the research on the leakage mechanism of gas drainage borehole, the rheological and visco-elastic-plastic characteristics were considered to establish the mechanical model of coal mass around borehole, which is used to analyze the leakage mechanism and deduce the dynamic leakage model. On the basis of the real coal seam conditions, the variation rules of the stress, leakage ring, and air leakage amount were analyzed through numerical simulation, and the influence factors of air leakage amount were also investigated to provide the theoretical basis for the sealing technology. Results show that the air leakage amount of borehole is inversely proportional to the increase in supporting stress and sealing length, and directly correlated with the increase in borehole radius and softening modulus. Using theoretical analysis, we design a novel active supporting sealing technology that can use grouting material to seal the fractures to reduce the leakage channels and also provide supporting stress to prevent borehole deformation. The engineering test results indicate that the average gas concentration with the novel active supporting sealing technology is increased by 162.12% than that of traditional polyurethane sealing method. Therefore, this technology not only effectively resolves borehole leakage but also significantly improves the gas drainage effect. | Zhang Junxiang Li Bo Sun Yuning | 2018 | International Journal of Mining Science and Technology2018，28，3： | 5 |
| 12 | Application of Contact Graph Routing in Satellite Delay Tolerant Networks显示文摘Satellite networks have many inherent advantages over terrestrial networks and have become an important part of the global network infrastructure.Routing aimed at satellite networks has become a hot and challenging research topic.Satellite networks,which are special kind of Delay Tolerant Networks(DTN),can also adopt the routing solutions of DTN.Among the many routing proposals,Contact Graph Routing(CGR) is an excellent candidate,since it is designed particularly for use in highly deterministic space networks.The applicability of CGR in satellite networks is evaluated by utilizing the space oriented DTN gateway model based on OPNET(Optimized Network Engineering Tool).Link failures are solved with neighbor discovery mechanism and route recomputation.Earth observation scenario is used in the simulations to investigate CGR's performance.The results show that the CGR performances are better in terms of effectively utilizing satellite networks resources to calculate continuous route path and alternative route can be successfully calculated under link failures by utilizing fault tolerance scheme. | ZHU Laitao LI Yong ZHANG Junxiang WU Jing TAI Xiao ZHOU Jianguo | 2015 | 空间科学学报2015，35，1： | 5 |
| 13 | Phaeocystis globosa Bloom Monitoring: Based on P. globosa Induced Seawater Viscosity Modification Adjacent to a Nuclear Power Plant in Qinzhou Bay, China显示文摘The mucus produced by the outbreak of Phaeocystis globosa in the adjacent waters of the Fangchenggang Nuclear Power Plant(FCGNPP) in China has blocked the entrance of the cooling water filtration system of the FCGNPP, and posed a threat to the safe operation of the FCGNPP. At present, there is no related research on whether the changes in seawater viscosity could be used as a new method for monitoring and providing early warning of P. globosa tide. During a complete red tide cycle, the temporal and spatial changes in the hydrological conditions(temperature, salinity, dissolved oxygen), chlorophyll-a(Chl-a), composition and abundance of phytoplankton, number and size of P. globose colonies, concentration of transparent exopolymer particles(TEP) and the seawater viscosity were measured in this study. The results indicate that there was an extremely significant negative correlation between the physical seawater viscosity η_(T,S) and temperature, and the correlation coefficient reached-0.998. The biological seawater viscosity η_(Bio) was positively correlated with the number of P. globosa colonies, and the correlation coefficients is 0.747. Because the increase in phytoplankton abundance, especially during the outbreak of P. globosa and a large amount of mucus produced by the colonies could significantly increase seawater viscosity, we suggest that biological factors were the main reasons for the increase in seawater viscosity. The η_(Bio) was completely consistent with the occurrence process of P. globosa bloom and could be used as a valuable index for P. globosa bloom monitoring. | KANG Zhenjun YANG Bin LAI Junxiang NING Yi ZHONG Qiuping LU Dongliang LIAO Riquan WANG Pei Solomon Felix Dan SHE Zhicai JIA Zhen LAO Yanling LI Nan | 2020 | Journal of Ocean University of China2020，19，5： | 5 |
| 14 | Malignant transformation of craniopharyngioma in an infradiaphragmatic case显示文摘Till now,13 cases of malignant craniopharyngioma (CP) have been reported around the world,including 11 cases of transformation from benign tumors and 2 cases of congenital ones.Irradiation seemed to contribute a lot to the cellular transformation.The controversies about the radical surgery or irradiation have not ceased for many decades.In this article,we report a case of infradiaphragmatic CP (Id-CP) in a child who experienced almost all current treatments.However,after multiple tumor recurrences,finally the malignant transformation occurred.The analysis of the tumor regrowth pattern and clinical characteristics provided some clues to standardize and individualize the treatment of Id-CP. | Lu Yuntao Qi Songtao Peng Junxiang Pan Jun Zhang Xi'an | 2014 | Chinese Medical Journal2014，，17： | 4 |
| 15 | Effect of Sulphur in Rainfall, Irrigation Waterand Perco colating Water on Soil Sulphur in Jiangxi Province显示文摘Ten rainfall and irrigation water-collecting posts were set up in different ecotype districts of JiangxiProvince, China, to quarterly measure S content in rainfall and irrigation water. A rainwater chemicalcomposition- collecting device was used to collect the sulphur in rainfall land the amount of sulphur adsorbedon the resin column in the device was determined. The soil percolating water was gathered using 6 lysimeters,built up according to the profile sequence of the red soil derived from red sandstone and the red soil derivedfrom Quaternary red clay, separately. On the lysimeters peanuts, soybean and radish were grown in rotation.Two treatments were designed: without S addition and with S addition at a rate of 14 kg S ha-1. The SO24contents in rainfall, irrigation water and soil percolating water were determined by the turbidimetry.The results in 1997 showed that the average annual S content in rainwater was 28.13 kg S ha-1, theaverage S content in irrigation water was 1.7 mg S L-1 , and the average content of in soil percolationwater was 2.30 kg S ha-1 year-1 and 4.70 kg S ha-l year-1 in treatments without and with sulphurapplication, respectively. In Jiangxi Province, apart from the losses by runoff and leaching, the sulphur inrainfall available to crops is 7.3 kg S ha-1 year-1 and additional S application is required. When rice isgrown , however, irrigation water can supply 6.9 kg S ha-1, which, along with the sulphur in rainfall, canalmost meet the S requirement of one cropping of rice. | LIU CHONGQUN CAO SHUQING and XU JUNXIANG(Institute of Soil Science, the Chinese Academy of Sciences, P.O. Box 821, Narolng 210008 China) | 2000 | Pedosphere2000，10，2： | 4 |
| 16 | Study of Aircraft Icing Warning Algorithm Based on Millimeter Wave Radar显示文摘In order to avoid accidents due to aircraft icing, an algorithm for identifying supercooled water was studied. Specifically, a threshold method based on millimeter wave radar, lidar, and radiosonde was used to retrieve the coverage area of supercooled water and a fuzzy logic algorithm was used to classify the observed meteorological targets. The macrophysical characteristics of supercooled water could be accurately identified by combing the threshold method with the fuzzy logic algorithm. In order to acquire microphysical characteristics of supercooled water in a mixed phase, the unimodal spectral distribution of supercooled water was extracted from a bimodal or trimodal spectral distribution of a mixed phase cloud, which was then used to retrieve the effective radius and liquid water content of supercooled water by using an empirical formula. These retrieved macro-and micro-physical characteristics of supercooled water can be used to guide aircrafts during takeoff, flight, and landing to avoid dangerous areas. | Jinhu WANG Junxiang GE Qilin ZHANG Pan FAN Ming WEI Xiangchao LI | 2017 | Journal of Meteorological Research2017，31，6： | 4 |
| 17 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 18 | Detailing interfacial reaction layer products between cubic boron nitride and Cu-Sn-Ti active filler metal显示文摘In the present study,we offer an in-depth analysis over the microstructure,thickness and product composition of the interfacial reaction layer generated upon CBN/Cu-Sn-Ti active filler metal at 1223 K.Current findings demonstrate that adequate wettability and satisfactory bonding have been achieved via chemical reactions between Ti and N,B.More importantly,we report,for the first time,the formation of a three-layer juxtaposition of reaction products,namely,TiN,TiB2 and TiB,along the diffusion path of Ti.Meanwhile,we determine the average layer thickness to be 1.24 μm.Through deep etching,we unambiguously present morphologies of the newly formed TiN and TiB2,which are columnar and bulky,re spectively,and constitute the formation of a high strength metallu rgical interfacial bonding layer,and is crucial towards gaining enhanced grinding performance.Finally,we propose a possible reaction sequence and mechanism that govern the nucleation and growth of corre s ponding crystals. | Yonggang Fan Junxiang Fan Cong Wang | 2021 | Journal of Materials Science & Technology2021，，9： | 3 |
| 19 | MR diffusion-weighted imaging of rabbit liver VX-2 tumor显示文摘AIM: To investigate the implanting method of rabbit liver VX-2 tumor and its MR diffusion-weighted imaging (DWI) characteristics.METHODS: Thirty-five New Zealand rabbits were included in the study. VX-2 tumor was implanted subcutaneously in 14 rabbits and intrahepatically in 6 for pre-experiments. VX-2 tumor was implanted intrahepatically in 12 rabbits for experiment and three were used as the control group. DWI, T1- and T2-weighted of MR1 were performed periodically in 15 rabbits for experiment before and after implantation. The distinction of VX-2 tumors on DWI was assessed by their apparent diffusion coefficient (ADC) values. The statistical significance was calculated byanalysis of variance (ANOVA) of the randomized block design using SPSS10.0 software. RESULTS: The successful rate of subcutaneous implantation of VX-2 tumor was 29% (4/14) while that of intrahepatic implantation of it was 33% (2/6) in the preexperiment. The successful rate of intrahepatic implantation of VX-2 tumor in the experiment was 83% (10/12) and 15 tumors grew in 10 successfully implanted rabbits. The DWT signal of VX-2 tumor was high and became lower when the b value increased step by step. The signal of VX-2 tumor on the map of ADC was low. When the b value was 100 or 300 s/mm2, the ADC value of normal group and VX-2 tumor group was respectively 2.57±0.26, 1.73±0.31, 1.87±0.25 and 1.57±0.23 mm2/s. Their distinction was significant (F= 43.26, P<0.01), the tumor ADC value between b values 100 and 300 s/mm2 wassignificant (Tukey HSP, P<0.05) and the ADC value between VX-2 tumor and normal liver was also significant (Tukey HSP, P<0.01). VX-2 tumor developed quickly and metastasized early to all body, especially to the lung, liver, lymph nodes of mediastinum, etc.CONCLUSION: The DWI signal of rabbit VX-2 tumor has its characteristics on MR DWI and DWI plays an important role in diagnosing and discovering VX-2 tumor. | You-HongYuan En-HuaXiao JunXiang Ke-LiTang KeJin Shi-JianYi QiangYin Rong-HuaYan ZhongHe Quan-LiangShang Wei-ZhouHu Su-WenYuan | 2005 | World Journal of Gastroenterology2005，11，20： | 3 |
| 20 | Grazing alters environmental control mechanisms of evapotranspiration in an alpine meadow of the tibetan Plateau显示文摘Aims Evapotranspiration(Et)is an important component of the terrestrial water cycle and is easily affected by external disturbances,such as climate change and grazing.Identifying Et responses to grazing is instructive for determining grazing activity and informative for understanding the water cycle.Methods this study utilized 2 years(2014 and 2017)of eddy covariance data to test how grazing regulated Et for an alpine meadow ecosystem on the tibetan Plateau(tP)by path analysis.Important Findings Radiation dominated Et with a decision coefficient of 64-74%.the soil water content(SWc)worked as the limiting factor in the fenced site.However,in the grazing site,the limiting factor was the vapor pressure deficit(VPD).Grazing had large effects on Et because it greatly affected the water conditions.the SWc and VPD were enhanced by 14.63%and 4.36%in the grazing site,respectively.therefore,sufficient water was supplied to Et,especially during drought,and strengthened the transpiration pull.As a result,a favorable micrometeorological environment was created for Et.Grazing shifted the limiting factor of Et from the SWc to VPD,which weakened the limiting effect of the water conditions on Et and advanced the Et peak time.In addition,grazing altered the compositions of Et by changing the community structure,which directly resulted in an increased Et.In summary,grazing enhanced Et through altering the community structure and micrometeorological environments.the findings of this study further improve our understanding of the driving mechanisms of grazing on Et and will improve our predictions for the global water cycle. | Tingting An Mingjie Xu Tao Zhang Chengqun Yu Yingge Li Ning Chen Jiaxing Zu Junxiang Li Juntao Zhu Yi Sun Tingting Zhao Guirui Yu | 2019 | Journal of Plant Ecology2019，12，5： | 3 |
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