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| 1 | Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma显示文摘AIM: To study the implication of prokineticin 1 (PK1/EG- VEGF) and prokineticin 2 (PK2/Bv8) in hepatocellular carcinoma angiogenesis. METHODS: The gene induction of PK1/EG-VEGF and PK2/Bv8 was investigated in 10 normal, 28 fibrotic and 28 tumoral livers by using real time PCR. Their expression was compared to the expression of VEGF (an angiogenesis marker), vWF (an endothelial cell marker) and to CD68 (a monocyte/macrophage marker). Furthermore, the mRNA levels of PK1/EG-VEGF, PK2/Bv8, prokineticin receptor 1 and 2 were evaluated by real time PCR in isolated liver cell populations. Finally, PK2/Bv8 protein was detected in normal liver paraffin sections and in isolated liver cells by immunohistochemistry and immunocytochemistry. RESULTS: PK2/Bv8 mRNA but not PK1/EG-VEGF was expressed in all types of normal liver samples examined. In the context of liver tumor development, we reported that PK2/Bv8 correlates only with CD68 and showed a significant decrease in expression as the pathology evolves towards cancer. Whereas, VEGF and vWF mRNA were significantly upregulated in both fibrosis and HCC,as expected. In addition, out of all isolated liver cells examined, only Kupffer cells (liver resident macrophages) express significant levels of PK2/Bv8 and its receptors, prokineticin receptor 1 and 2. CONCLUSION: In normal liver PK2/Bv8 and its receptors were specifically expressed by Kupffer cells. PK2/Bv8 expression decreased as the liver evolves towards cancer and did not correlate with HCC angiogenesis. | Justin Monnier Claire Piquet-Pellorce Jean-Jacques Feige Orlando Musso Bruno Clément Bruno Turlin Nathalie Théret Michel Samson | 2008 | World Journal of Gastroenterology2008，14，8： | 4 |
| 2 | Infection with Influenza Virus Induces IL-33 in Murine Lungs显示文摘 | Le Goffic Ronan Arshad Muhammad Imran Rauch Michel L’Helgoualc’h Annie Delmas Bernard Piquet-Pellorce Claire Samson Michel | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，6： | 1 |
| 3 | Core stabile- nation training program for tennis athletes显示文摘 | Kim M samson Michelle A Sandrey A | 2007 | Athol Therapy Today2007，，5： | 1 |
| 4 | Core stabilization training program for tennis athletes 显示文摘 | Kim M Samson Michelle A Sandrey A | 2007 | Athl Therapy To- day2007，74，5： | 1 |
| 5 | Core stabile-nation training program for tennis athletes显示文摘 | Kim M samson Michelle A Sandrey A | 2007 | Athol Therapy Today2007，，5： | 1 |
| 6 | Core stabilization training program for tennis athletes显示文摘 | KIM M SAMSON MICHELLE A SANDREY A | 2007 | Athl Therapy Today2007，，5： | 1 |
| 7 | Core stabile-nation training programfor tennis athletes显示文摘 | Kim M samson Michelle A Sandrey A | 2007 | Athol Therapy Today2007，，5： | 1 |
| 8 | A core stabilization training program for tennis athletes显示文摘 | KIM M SAMSON MICHELLE A SANDREY ALLISON HET-RICK | | 0，，03： | 1 |
| 9 | Core stabile - nation trainingprogramfor tennis athletes 显示文摘 | Kim M samson Michelle A Sandrey A | 2007 | Athol Therapy Today2007，，5： | 1 |
| 10 | A core stabilization training program for tennis athletes显示文摘 | KIM M SAMSON MICHELLE A SANDREY ALLISON HETRICK | 2007 | Athletic Theraphy Today2007，12，3： | 1 |
| 11 | Infection with Influenza Virus Induces IL-33 in Murine Lungs显示文摘 | Le Goffic Ronan Arshad Muhammad Imran Rauch Michel L’Helgoualc’h Annie Delmas Bernard Piquet-Pellorce Claire Samson Michel | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，6： | 1 |
| 12 | Core stabilization training program for tennis athletes显示文摘 | Kim M Samson Michelle A Sandrey | | 0，，05： | 1 |
| 13 | Core stabilization training program for tennis athletes显示文摘 | KIM M SAMSON MICHELLE A SANDREY A | 2007 | Athl Therapy Today2007，，5： | 1 |
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