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| 1 | Distribution of chlorpyrifos in rice paddy environment and its potential dietary risk显示文摘Chlorpyrifos is one of the most extensively used insecticides in China. The distribution and residues of chlorpyrifos in a paddy environment were characterized under field and laboratory conditions. The half-lives of chlorpyrifos in the two conditions were 0.9–3.8 days(field) and 2.8–10.3 days(laboratory), respectively. The initial distribution of chlorpyrifos followed the increasing order of water < straw < soil, and soil was characterized as the major absorber. The ultimate residues in rice grain were below the maximum residue limit(MRL) with a harvest interval of 14 days. The chronic exposure for chlorpyrifos was rather low compared to the acceptable daily intake(ADI = 0.01 mg/kg bw) due to rice consumption. The chronic exposure risk from chlorpyrifos in rice grain was 5.90% and 1.30% ADI from field and laboratory results respectively. Concerning the acute dietary exposure,intake estimated for the highest chlorpyrifos level did not exceed the acute reference dose(ARf D = 0.1 mg/kg bw). The estimated short-term intakes(ESTIs) were 0.78% and 0.25% of the ARf D for chlorpyrifos. The results showed that the use of chlorpyrifos in rice paddies was fairly safe for consumption of rice grain by consumers. | Yan Fu Feifei Liu Chenglin Zhao Ying Zhao Yihua Liu Guonian Zhu | 2015 | Journal of Environmental Sciences2015，27，9： | 5 |
| 2 | Impacts of land conversion and management measures on net primary productivity in semi-arid grassland显示文摘Ecological restoration measures implemented in China have profoundly impacted vegetation NPP.This study aimed to estimate the effects of the land conversion and management measures on the grassland ecosystem in semi-arid regions.Land use data were employed from 2000 to 2015 to compare land conversion and coverage changes in Xilingol grassland.Then,the contributions of land conversion and management policies were quantified by assessing the difference between actual NPP and climate-induced NPP changes.The results indicated that the grassland area had a net loss of 534.42 km^(2),and the net area of increased vegetation coverage was 74,683.05 km^(2).Furthermore,the total NPP increased by 8,010.73 Gg C·yr^(−1)(1 Gg=10^(9)g),of which the human activities,including grazing management measures(+6,809.40 Gg C·yr^(−1))and land conversion(45.72 Gg C·yr^(−1))contributed to 85.58%of the increase in NPP.Transformation from desert and farmland dominated grassland expansion and NPP increase,while urbanization and desertification caused large grassland reduction and NPP loss.The grazing management increased vegetation NPP in most regions except for some regions in the desert steppe and the farming-pastoral zone.Related policies should be further adjusted to strengthen the management of the desert steppe and farming-pastoral regions. | Feifei Cao Jiaxun Li Xiao Fu Gang Wu | 2020 | Ecosystem Health and Sustainability2020，6，1： | 4 |
| 3 | Flow characterization of high-pressure dense-phase pneumatic conveying of coal powder using multi-scale signal analysis显示文摘 | Feifei Fu Chuanlong Xu Shimin Wang | 2018 | Particuology2018，16，1： | 2 |
| 4 | Control of COD/N ratio for nutrient removal in a modified membrane bioreaetor (MBR) treating high strength wastewater 显示文摘 | Zhimin Fu Fenglin Yang Feifei Zhou | 2009 | Bioresource Technology2009，，100： | 1 |
| 5 | Seed-mediated synthesis and the photo-degradation activity of ZnO-graphene hybrids exclu- ding the influence of dye adsorption 显示文摘 | Fu Dong'ying Han Gaoyi Yartg Feifei et a| | 2013 | Applied Surface Science2013，283，20： | 1 |
| 6 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 7 | Control of COD/N ratio for nutrient removal in a modified membrane bioreactor(MBR) treating high strength wastewater显示文摘 | Fu Zhimin Yang Fenglin Zhou Feifei | 2009 | Bioresource Technology2009，100，1： | 1 |
| 8 | Control of COD/N ratio for nutrient removal in a modified membrane bioreactor (MBR) trea- ting high strength wastewater显示文摘 | Fu Zhimin Yang Fenglin Zhou Feifei | 2009 | Bioresource Technology2009，100，1： | 1 |
| 9 | Control of COD/N ratio for nutrient removal in a modified mem- brane bioreactor (MBR) treating high strength waste- water显示文摘 | Fu Zhimin Yang Fenglin Zhou Feifei | 2009 | Bioresour Technol2009，100，1： | 1 |
| 10 | Control of COD/N ratio for nutrient removal in a modified membrane bioreactor (MBR) treating high strength wastewater显示文摘 | Fu Zhimin Yang Fenglin Zhou Feifei | 2009 | Bioresource Technology2009，100，： | 1 |
| 11 | Structural and functional analysis of a potent human neutralizing antibody against enterovirus A71显示文摘Enterovirus A71(EV-A71) causes major outbreaks of hand,foot,and mouth disease(HFMD) in many countries,most frequently affecting children,and a small proportion of cases may lead to death.Currently,no vaccine is available in most endemic regions,and no licenced treatments for EV-A71 infection are available.Here,we characterize a human monoclonal antibody(Hu MAb),E1,by screening a Fab antibody phage library derived from patients who recovered from EV-A71 infection.E1 exhibits strong neutralizing activity against EV-A71 virus in cells.The cryo-electron microscopy(cryo-EM) structures of the EV-A71 virion in complex with E1 Fab fragments demonstrated that E1 recognized an epitope formed by residues in the BC and HI loops of VP1.In a mouse model,E1 effectively protected against lethal EV-A71 challenge in both prophylactic and therapeutic treatment.In particular,E1 significantly reduces virus titers and muscle damage.E1 might represent a potential adjunct to EV-A71 treatment. | Zhe Chen Linlin Bao Bin Zhu Hua Fu Shuangli Zhu Tianjiao Ji Ying Xue Chuan Liu Xurong Wang Fengdi Li Qi Lv Feifei Qi Pin Yu Wei Deng Wenbo Xu Chuan Qin Hongrong Liu Qi Jin | 2022 | Science China(Life Sciences)2022，65，12： | 0 |
| 12 | SENP5 deteriorates traumatic brain injury via SUMO2- dependent suppression of E2F1 SUMOylation显示文摘Traumatic brain injury(TBI)represents a main public health concern during the past decade,attracting considerable interest because of its rising prevalence,wide-ranging risk factors and lifelong familial and societal influence.SUMO2 can conjugate to substrates upon various cellular stresses.Nevertheless,whether and how SUMO2-specific proteases partake in TBI is less understood.The aim of this study is to dissect the effects of SUMO-specific peptidase 5(SENP5)on accentuating TBI in rats in an effort to unveil its underlying mechanism.SENP5 is overexpressed in hippocampal tissues of TBI rats,and inhibition of SENP5 reduces neurological function scores,decreases brain water content,inhibits apoptosis in hippocampal tissues,and attenuates brain injury caused in rats.Moreover,SENP5 inhibits the SUMOylation level of E2F transcription factor 1(E2F1)and increases the protein expression of E2F1.Silencing of E2F1 blocks the p53 signaling pathway.Overexpression of E2F1 partially reverses the protective effect of sh-SENP5 on TBI in rats.These findings reveal an essential role of SENP5 and the SUMOylation status of E2F1 in the TBI development. | Yanfu Ding Feifei Chen Weitao Yang Xiaobin Fu Yuanyuan Xie | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 13 | Negative refraction mediated by bound states in the continuum显示文摘Negative refraction might occur at the interface between a two-dimensional photonic crystal(Ph C)slab and a homogeneous medium,where the guiding of the electromagnetic wave along the third dimension is governed by total internal reflection.Herein,we report on the observation of negative refraction in the Ph C slab where the vertical guiding is enabled by a bound state in the continuum and essentially beyond the light cone.Such abnormal refraction and guiding mechanism are based on the synchronous crafting of spatial dispersion and the radiative lifetime of Bloch modes within the radiative continuum.Microwave experiments are provided to further validate the numerical proposal in an all-dielectric Ph C platform.It is envisioned that the negative refraction observed beyond the light cone might facilitate the development of optical devices in integrated optics,such as couplers,multiplexers,and demultiplexers. | ZHANYUAN ZHANG FEIFEI QIN YI XU SONGNIAN FU YUNCAI WANG YUWEN QIN | 2021 | Photonics Research2021，9，8： | 0 |
| 14 | SYP-5 regulates meiotic thermotolerance in Caenorhabditis elegans显示文摘Meiosis produces the haploid gametes required by all sexually reproducing organisms,occurring in specific temperature ranges in different organisms.However,how meiotic thermotolerance is regulated remains largely unknown.Using the model organism Caenorhabditis elegans,here,we identified the synaptonemal complex(SC)protein SYP-5 as a critical regulator of meiotic thermotolerance.syp-5-null mutants maintained a high percentage of viable progeny at 20℃ but produced significantly fewer viable progeny at 25℃,a permissive temperature in wild-type worms.Cytological analysis of meiotic events in the mutants revealed that while SC assembly and disassembly,as well as DNA double-strand break repair kinetics,were not affected by the elevated temperature,crossover designation,and bivalent formation were significantly affected.More severe homolog segregation errors were also observed at elevated temperature.A temperature switching assay revealed that late meiotic prophase events were not temperature-sensitive and that meiotic defects during pachytene stage were responsible for the reduced viability of syp-5 mutants at the elevated temperature.Moreover,SC polycomplex formation and hexanediol sensitivity analysis suggested that SYP-5 was required for the normal properties of the SC,and charge-interacting elements in SC components were involved in regulating meiotic thermotolerance.Together,these findings provide a novel molecular mechanism for meiotic thermotolerance regulation. | Yuanyuan Liu Qiuchen Zhao Hui Nie Fengguo Zhang Tingting Fu Zhenguo Zhang Feifei Qi Ruoxi Wang Jun Zhou Jinmin Gao | 2021 | Journal of Molecular Cell Biology2021，13，9： | 0 |
| 15 | HBXIP blocks myosin-ⅡA assembly by phosphorylating and interacting with NMHC-ⅡA in breast cancer metastasis显示文摘Tumor metastasis depends on the dynamic balance of the actomyosin cytoskeleton.As a key component of actomyosin filaments,non-muscle myosin-ⅡA disassembly contributes to tumor cell spreading and migration.However,its regulatory mechanism in tumor migration and invasion is poorly understood.Here,we found that oncoprotein hepatitis B X-interacting protein(HBXIP) blocked the myosin-ⅡA assemble state promoting breast cancer cell migration.Mechanistically,mass spectrometry analysis,co-immunoprecipitation assay and GST-pull down assay proved that HBXIP directly interacted with the assembly-competent domain(ACD) of non-muscle heavy chain myosin-ⅡA(NMHC-ⅡA).The interaction was enhanced by NMHC-ⅡA S1916 phosphorylation via HBXIP-recruited protein kinase PKCβⅡ.Moreover,HBXIP induced the transcription of PRKCB,encoding PKCβⅡ,by coactivating Sp1,and triggered PKCβⅡ kinase activity.Interestingly,RNA sequencing and mouse metastasis model indicated that the anti-hyperlipidemic drug bezafibrate(BZF) suppressed breast cancer metastasis via inhibiting PKCβⅡ-mediated NMHC-ⅡA phosphorylation in vitro and in vivo.We reveal a novel mechanism by which HBXIP promotes myosin-ⅡA disassembly via interacting and phosphorylating NMHC-ⅡA,and BZF can serve as an effective anti-metastatic drug in breast cancer. | Lu Zhang Xiaolei Zhou Bowen Liu Xuhe Shi Xianmeng Li Feifei Xu Xueli Fu Xue Wang Kai Ye Tianzhi Jin Huimin Sun Qianqian Li Weiying Zhang Lihong Ye | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
| 16 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
| 17 | cGAS regulates the DNA damage response to maintain proliferative signaling in gastric cancer cells显示文摘The activation of some oncogenes promote cancer cell proliferation and growth,facilitate cancer progression and metastasis by induce DNA replication stress,even genome instability.Activation of the cyclic GMP-AMP synthase(cGAS)mediates classical DNA sensing,is involved in genome instability,and is linked to various tumor development or therapy.However,the function of cGAS in gastric cancer remains elusive.In this study,the TCGA database and retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and cell lines.By employing cGAS high-expression gastric cancer cell lines,including AGS and MKN45,ectopic silencing of cGAS caused a significant reduction in the proliferation of the cells,tumor growth,and mass in xenograft mice.Mechanistically,database analysis predicted a possible involvement of cGAS in the DNA damage response(DDR),further data through cells revealed protein interactions of the cGAS and MRE11-RAD50-NBN(MRN)complex,which activated cell cycle checkpoints,even increased genome instability in gastric cancer cells,thereby contributing to gastric cancer progression and sensitivity to treatment with DNA damaging agents.Furthermore,the upregulation of cGAS significantly exacerbated the prognosis of gastric cancer patients while improving radiotherapeutic outcomes.Therefore,we concluded that cGAS is involved in gastric cancer progression by fueling genome instability,implying that intervening in the cGAS pathway could be a practicable therapeutic approach for gastric cancer. | BIN LIU HAIPENG LIU FEIFEI REN HANGFAN LIU IHTISHAM BUKHARI YUMING FU WANQINGWU MINGHAI ZHAO SHAOGONG ZHU HUI MO FAZHAN LI MICHAEL B.ZHENG YOUCAI TANG PENGYUAN ZHENG YANG MI | 2021 | Oncology Research2021，29，2： | 0 |
| 18 | Hierarchically Structured Nb_(2)O_5 Microflowers with Enhanced Capacity and Fast-Charging Capability for Flexible Planar Sodium Ion Micro-Supercapacitors显示文摘Planar Na ion micro-supercapacitors(NIMSCs) that offer both high energy density and power density are deemed to a promising class of miniaturized power sources for wearable and portable microelectron-ics. Nevertheless, the development of NIMSCs are hugely impeded by the low capacity and sluggish Na ion kinetics in the negative electrode.Herein, we demonstrate a novel carbon-coated Nb_(2)O_5 microflower with a hierarchical structure composed of vertically intercrossed and porous nanosheets, boosting Na ion storage performance. The unique structural merits, including uniform carbon coating, ultrathin nanosheets and abun-dant pores, endow the Nb_(2)O_5 microflower with highly reversible Na ion storage capacity of 245 mAh g^(-1) at 0.25 C and excellent rate capability.Benefiting from high capacity and fast charging of Nb_(2)O_5 microflower, the planar NIMSCs consisted of Nb_(2)O_5 negative electrode and activated car-bon positive electrode deliver high areal energy density of 60.7 μWh cm^(-2),considerable voltage window of 3.5 V and extraordinary cyclability. Therefore, this work exploits a structural design strategy towards electrode materials for application in NIMSCs, holding great promise for flexible microelectronics. | Jiaxin Ma Jieqiong Qin Shuanghao Zheng Yinghua Fu Liping Chi Yaguang Li Cong Dong Bin Li Feifei Xing Haodong Shi Zhong‑Shuai Wu | 2024 | Nano-Micro Letters2024，16，4： | 0 |
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