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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | A double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of vascular depression显示文摘 | Taracano FE Allecri R Vicario A | 2005 | Int J Geriatr Psychiatry2005，16，3： | 1 |
| 3 | Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells显示文摘 | Zhao R Xiang N Domann FE | 2009 | Nutrition and cancer2009，61，： | 1 |
| 4 | Testosterone and friailty显示文摘 | Kaise FE Sih R | 1997 | Clin Geriatr Med1997，13，4： | 1 |
| 5 | Sputum eosinophil count to assess compliance with corticosteroid therapy in asthma 显示文摘 | Parameswaran K Leigh R Hargreave FE | 1999 | J Allergy] Clin Immunol1999，104，： | 1 |
| 6 | Safety of sputum induction in moderate-to-severe smoking-related chronic obstructive pulmonary disease显示文摘 | Wilson AM Leigh R Hargreave FE | 2006 | COPD2006，3，2： | 1 |
| 7 | Results in resident cholasteatoma surgery: a review of 85 cases显示文摘 | Moss R Lucente FE | 1987 | Laryngoscope1987，97，2： | 1 |
| 8 | From pine plan- tations to natural stands : Ecological restoration of a Pinus canariensis Sweet ex Spreng forest 显示文摘 | Arevalo J R Fe rnandez-Pa lacios J M | 2005 | Plant Ecology2005，181，2： | 1 |
| 9 | Testosterone replacement in older hypogonadal meu: a 12-month randomized controlled trial 显示文摘 | Sih R Morley JE Kaiser FE el al | 1997 | J Clin Endocrinol1997，82，： | 1 |
| 10 | A double blind,randomized clinical trial as- sessing the efficacy and safety of augment- ing standard antidepressant therapy with nimodipine in the treatment of vascular depression 显示文摘 | Taragano FE Allegri R Vicario A | 2001 | Int J Geriatr Psychiatry2001，16，3： | 1 |
| 11 | A double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of vascular depression显示文摘 | Taragano FE Allegri R Vicario A | 2001 | Int J Geriatr psychiatry2001，16，3： | 1 |
| 12 | Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway显示文摘 | Lehnardt S Massillou L Follett P Jensen FE Ratan R Rosenberg DA | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 13 | Preventing postoperative complications in the elderly 显示文摘 | Sieber FE Barnett S R | 2011 | Anesthesiol Clin2011，29，1： | 1 |
| 14 | Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells显示文摘 | Zhao R Xiang N Domann FE | 2009 | Nutr cancer2009，61，3： | 1 |
| 15 | Physiology, signal- ing, and pharmacology of galanin peptides and receptors: three decades of emerging diversity 显示文摘 | Lang R Gundlach AL Holmes FE | 2015 | Pharmacol Rev2015，67，1： | 1 |
| 16 | Vascular endothelial growth factor regulates reendothelialization and neointima formation in a mouse model of arterial injury 显示文摘 | Hutter R Carrick FE Valdiviezo C | 2004 | Circulation2004，110，16： | 1 |
| 17 | Fortification of suger with FeNaDETA improves iron status in semirural Guatemalan populations显示文摘 | Viteri FE Alvarez E Baters R | 1995 | Am J Clin Nutr1995，61，： | 1 |
| 18 | Upregulation of bone cel differentiation through immobilization within a synthetic extracel ular matrix显示文摘 | Evangelista MB Hsiong SX Fe rnandes R | | 0，，25： | 1 |
| 19 | Determinants of early versus late cardiac death in patients undergoing coronary artery bypass graft Surgery显示文摘 | Harrell FE Jr Rankin JS | 1991 | Circulation1991，84，5： | 1 |
| 20 | Novel imaging techniques reshape the landscape in high-risk prostate cancers显示文摘 | LECOUVET FE LHOMMEL R PASOGLOU V | | 0，，： | 1 |
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