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| 1 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Alveolar echinococcosis-spreading disease challenging clinicians: A case report and literature review显示文摘Human alveolar echinococcosis (AE) is a potentially deadly disease; recent studies have shown that the endemic area of Echinococcus multilocularis , its causative agent, is larger than previously known. This disease has low prevalence and remains underreported in Europe. Emerging clinical data show that diagnostic difficulties are still common. We report on a 76-year old patient suffering from AE lesions restricted to the left lobe of the liver who underwent a curative extended left hemihepatectomy. Prior to the resection a liver biopsy under the suspicion of an atypical malignancy was performed. After the intervention he developed a pseudoaneurysm of the hepatic artery that was successfully coiled. Surprisingly, during surgery, the macroscopic appearance of the tumour revealed a growth pattern that was rather typical for cystic echinococcosis (CE), i.e. , a gross tumour composed of multiple large vesicles with several centimeters in diameter. In addition, there were neither extensive adhesions nor infiltrations of the neighboring pancreas and diaphragm as was expected from previous imaging results. The unexpected diagnosis of AE was confirmed by definite histopathology, specific polymerase chain reaction and serology results. This is a rare case of unusual macroscopic presentation of AE that posed immense diagnostic challenges and had an eventful course. To our knowledge this is the first case of an autochthonous infection in this particular geographic area of Germany, the federal state of Saxony. This report may provide new hints for an expanding area of risk for AE and emphasizes the risk of complications in the scope of diagnostic procedures and the limitations of modern radiological imaging. | Georgi Atanasov Christoph Benckert Armin Thelen Dennis Tappe Matthias Frosch Dieter Teichmann Thomas FE Barth Christian Wittekind Stefan Schubert Sven Jonas | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 3 | 老年人的便秘问题显示文摘便秘常发生在老年人,通常病因很多。基本病因的研究是必不可少的。充分采集病史、完整的体格捡查常可明确诊断。但少数患者须作进一步捡查。处理包括治疗基本病因;进食富含纤维的食物;摄入足够的水分;给予药物恢复正常大便习惯,但较不常用。 | Murray FE Bliss CM 林祥春 | 1991 | 国外医学(老年医学分册)1991，12，6： | 11 |
| 4 | 对遗传性易栓症检查与治疗的指导意见显示文摘国际上对易栓症尚无统一的定义。英国血液学会标准化委员会提出,易栓症是指“易导致血栓形成的止血机理异常”。这个定义被广泛地采用,但也有两点不足之处:①随着新的易栓状态不断发现,很多有这类异常的人并无症状;②虽然已认识到各种能增加血栓危险的异常,但至少50%有血栓病史的患者经详细的实验室检查后仍找不到原因。在北美地区医生将易栓症患者限定为有自发性静脉血栓或其严重性比预期的高,或反复性静脉血栓发作,或在年青时就有静脉血栓的人。这个概念可能在临床上更有用。 | Walker ID Greaves M Preston FE 王兆钺 | 2004 | 国外医学(输血及血液学分册)2004，27，6： | 8 |
| 5 | Short-term effectiveness of golimumab for ulcerative colitis: Observational multicenter study显示文摘AIM To evaluate the real-world effectiveness of golimumab in ulcerative colitis(UC) and to identify predictors of response.METHODS We conducted an observational, prospective and multi-center study in UC patients treated with golimumab, from September 2014 to September 2015. Clinical activity was assessed at wk 0 and 14 with the physician's global clinical assessment(PGA) and the partial Mayo score. Colonoscopies and blood tests were performed, following daily-practice clinical criteria, and the results were recorded in an SPSS database.RESULTS Thirty-three consecutive patients with moderately to severely active UC were included. Among them, 54.5% were female and 42 years was the average age. Thirty percent had left-sided UC(E2) and 70% had extensive UC(E3). All patients had an endoscopic Mayo score of 2 or 3 at baseline. Twenty-seven point three percent were anti-tumor necrosis factor(TNF) treatment na?ve, whereas 72.7% had previously received infliximab and/or adalimumab. Sixty-nine point seven percent showed clinical response and were steroid-free at wk 14(a decrease from baseline in the partial Mayo score of at least 3 points). Based on PGA, the clinical remission and clinical response rates were 24% and 55% respectively. Withdrawal of corticosteroids was observed in 70.8% of steroid-dependent patients at the end of the study. Three out of 10 clinical non-responders needed a colectomy. Mean fecal calprotectin value at baseline was 300 μg/g, and 170.5 μg/g at wk 14. Being anti-TNF treatment na?ve was a protection factor, which was related to better chances of reaching clinical remission. Twenty-seven point three percent of the patients required treatment intensification at 14 wk of followup. Only three adverse effects(AEs) were observed during the study; all were mild and golimumab was not interrupted.CONCLUSION This real-life practice study endorses golimumab's promising results, demonstrating its short-term effectiveness and confirming it as a safe drug during the induction phase. | Marta Maia Bosca-Watts Xavier Cortes Marisa Iborra Jose Maria Huguet Laura Sempere Gloria Garcia Rafa Gil Mari Fe Garcia Marga Munoz Pedro Almela Nuria Maroto Jose Maria Paredes | 2016 | World Journal of Gastroenterology2016，22，47： | 5 |
| 6 | Jackknife and Bootstrap Tests of the Composition Vector Trees显示文摘Composition vector trees (CVTrees) are inferred from whole-genome data by an alignment-free and parameter-free method. The agreement of these trees with the corresponding taxonomy provides an objective justification of the inferred phylogeny. In this work, we show the stability and self-consistency of CVTrees by performing bootstrap and jackknife re-sampling tests adapted to this alignment-free approach. Our ultimate goal is to advocate the viewpoint that time-consuming statistical re-sampling tests can be avoided at all in using this alignment-free approach. Agreement with taxonomy should be taken as a major criterion to estimate prokaryotic phylogenetic trees. | Guanghong Zuo1,2, Zhao Xu1,3, Hongjie Yu1,4, and Bailin Hao1,5,6 1T-Life Research Center & Department of Physics, Fudan University, Shanghai 200433, China 2Shanghai Institute of Applied Physics, Chinese Acadamy of Sciences, Shanghai 201800, China 3Applied Biosystems, Inc., Beijing 100027, China 4Fudan-VARI Center for Genetic Epidemiology, Fudan University, Shanghai 200433, China 5Institute of Theoretical Physics, Chinese Acadamy of Sciences, Beijing 100190, China 6Santa Fe Institute, Santa Fe, NM 87505, USA. | 2010 | Genomics, Proteomics & Bioinformatics2010，8，4： | 5 |
| 7 | 淬速和热处理对纳米双相Nd_2Fe_(14)B/α-Fe磁体的性能和微结构的影响显示文摘用熔体快淬法制备了高性能纳米双相耦合Nd2Fe14B/α Fe磁体,研究了快淬速率和热处理工艺对其磁性能和微结构的影响。实验结果表明,控制快淬速率在12m·s-1时,可直接得到显微组织均匀、α Fe相粒子细小且均匀分布的纳米双相耦合Nd2Fe14B/α Fe磁体。低温退火处理后可消除由少量非晶相带来的成分不均匀性,其最高磁性能为iHc=432.2kA·m-1,Jr=1.08T,(BH)max=115kJ·m-3。快淬速率提高,非晶相体积分数增加,在高温晶化热处理时软硬磁相析出不均匀,个别α Fe相粒子奇异长大,尺寸达到100nm左右,这不利于软硬磁相间的交换耦合作用,有损磁性能。 | Effect of Wheel Speed and Annealing Process on the Magnetic Properties and Microstructure of Nanocomposite Nd2Fe14B/α-Fe Magnets 杨森 李山东 刘先松 谢国治 田宗军 宋晓平 顾本喜 都有为 | 2002 | 中国稀土学报2002，20，z2： | 4 |
| 8 | Prokaryote phylogeny meets taxonomy: An exhaustive comparison of composition vector trees with systematic bacteriology显示文摘We perform an exhaustive, taxon by taxon, comparison of the branchings in the composition vector trees (CVTrees) inferred from 432 prokaryotic genomes available on 31 December 2006, with the bacte-riologists' taxonomy-primarily the latest online Outline of the Bergey's Manual of Systematic Bacteri-ology. The CVTree phylogeny agrees very well with the Bergey's taxonomy in majority of fine branchings and overall structures. At the same time most of the differences between the trees and the Manual have been known to biologists to some extent and may hint at taxonomic revisions. Instead of demonstrating the overwhelming agreement this paper puts emphasis on the biological implications of the differences. | GAO Lei1,2, QI Ji1**, SUN JianDong2,3 & HAO BaiLin1,2,4 1 Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100080, China 2 T-Life Research Center, Fudan University, Shanghai 200433, China 3 Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China 4 Santa Fe Institute, Santa Fe, NM87501, USA Center for Comparative Genomics and Bioinformatics, Penn State University, 310 Wartik Building, University Park, PA16802, USA | 2007 | Science China(Life Sciences)2007，50，5： | 4 |
| 9 | VERTICAL HEREDITY VS. HORIZONTAL GENE TRANSFER: A CHALLENGE TO BACTERIAL CLASSIFICATION显示文摘The diversity and classification of microbes has been a long-standing issue.Molecular phylogeny of the prokaryotes based on comparison of the 16S rRNA sequences of the small ribosomal subunit has led to a reasonable tree of life in the late 1970s. How-ever, the availability of more and more complete bacterial genomes has brought about complications instead of refinement of the tree. In particular, it turns out that different choice of genes may tell different history. This might be caused by possible horizontal gene transfer (HGT) among species. There is an urgent need to develop phylogenetic methods that make use of whole genome data. We describe a new approach in molecular phylogeny,namely, tree construction based on K-tuple frequency analysis of the genomic sequences.Putting aside the technicalities, we emphasize the transition from randomness to determin-ism when the string length K increases and try to comment on the challenge mentioned in the title. | HAO Bailin(Institute of Theoretical Physics, Academy of Chinese Sciences, Beijing 100080, China Senior International Fellow of the Santa Fe Institute T-Life Research Center, Fudan University,Shanghai 200433, China)QI Ji(Institute of Theoretical Physics, Beijing 100080, China) | 2003 | Journal of Systems Science & Complexity2003，16，3： | 3 |
| 10 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 11 | ^(59)Fe在大鼠铁代谢研究中的应用显示文摘60只雄性SD断奶大鼠,分为铁正常、铁缺乏和铁缺乏补充铁10倍于常量三组。采用59Fe示踪法测量大鼠全身59Fe储留量和各器官、组织的分布。结果显示,铁正常组大鼠全身铁储留率为31.0%~36.0%,铁缺乏组大鼠为84.1%~93.3%,铁缺乏大鼠补铁后储留率由21.8%急剧下降至6.8%。铁缺乏组大鼠小肠粘膜、肝脏、血液与骨骼等铁吸收储留器官、组织铁的分布显著高于铁正常组大鼠,铁缺乏大鼠补铁后组织器官的分布最低。而小肠灌洗液、结肠和粪便内铁分布表现出完全相反的结果. | 刘戌年 Vite.,FE | 1994 | 营养学报1994，16，4： | 3 |
| 12 | Radiologic characterization of adrenal masses: the role of computed tomography-derived attenuation values显示文摘 | Nwariaku FE Champine J | 2001 | Surgery2001，130，6： | 2 |
| 13 | Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA显示文摘 | Chen FE Huang DB Chen YQ | 1998 | Nature1998，391，6665： | 2 |
| 14 | Endoscopic therapy for chronic pancreatitis 显示文摘 | Kasmin FE Siegel JH | 2001 | Surg Clin North Am2001，81，2： | 2 |
| 15 | Thalidomide and immunomodu latory derivatives augment natural killer cell cytotoxicity in multiple myeloma显示文摘 | Davies FE Raje N Hideshima T | | 0，，： | 2 |
| 16 | The polymorphism of heat shock protein 70 genes in Chinese Han population in Fujian province显示文摘To understand the polymorphism of the heat shock protein 70 (HSP70) genes in Chinese Han population and to explore the co-relations between HSP70 polymorphism and disease, three polymorphic loci of HSP70 genes in 127 healthy Chinese Han population in Fujian province were analyzed by PCR and restriction enzyme analysis, and the genotypes and allele frequencies of HSP70 in different populations from various area were compared. It was found that the proportions of HSP70-1 genotypes GG, GC and CC among Chinese Han population in Fujian province were 55.1%, 40.2% and 4.7% respectively, while those of HSP70-2 genotypes AA, AG and GG were 44.1%, 48.8% and 6.9% respectively, and those of HSP70-hom genotypes TT, TC and CC were 59.8%, 37.0% and 3.2% respectively. The allele frequencies of G and C in HSP70-1 were 75.2% and 24.8%; those of A and G in HSP70-2 were 68.5% and 31.5% and those of T and C in HSP70-hom were 78.3% and 21.7% respectively. The distribution of the HSP70-1 polymorphisms in Chinese Han population was almost the same as those in Japanese and Mexican populations, but it was rather different from those of American and Spanish populations with a significant differences. Meanwhile, the frequency of GG homozygote in HSP70-1 was significantly higher than those in American and Spanish populations. No significant difference was found in the distribution of HSP70-2 polymorphism between Chinese and Japanese populations, in which the differences among American, Mexican and Spanish populations were quite obvious. The frequency of AA homozygote in HSP70-2 was significantly higher than those in Mexican, American and Spanish populations, while, the distribution of HSP 70-hom genotype and allele frequency in Chinese Han population was almost just the same as those in Japanese and Mexican populations. Furthermore, it was also found that the genotype distribution and allele frequencies of the HSP70 genes in Han population of Fujian province were almost the same as those in Han population in Taiwan, but they were different in certain loci from those of Han population in Wuhan area. It is evident that the distribution of HSP70 gene polymorphisms among Chinese Han population are different from other regions in the world. | JING AN LIN WEN QING LI DE FE YE YUE YONG ZHU | 2005 | Journal of Microbiology and Immunology2005，3，3： | 2 |
| 17 | 低污染小型直喷式柴油机燃烧系统的改进显示文摘 | Corc.,FE 王耀清 | 1992 | 国外内燃机1992，24，5： | 2 |
| 18 | 产后早期同伴(母亲之间)电话咨询积极支持母乳喂养:一项多中心、非盲、随机对照研究显示文摘背景:目前全球的母乳喂养率都不太理想,很多婴儿生后6个月内从未摄入母乳。很少有措施能有效延长母乳喂养持续时间,特别是在母乳喂养启动率较高的地区。有研究发现同伴(母亲)间的积极支持在特定情况下可促进母乳喂养.如果被证明有效,可考虑作为一种可持续模式在多个地区实施。本研究旨在确定产后阶段同伴间的积极电话支持能否提高6月龄婴儿的母乳喂养率。 | 高谦 张馨月(审校) Forster DA McLardie-Hore FE McLachlan HL | 2019 | 中华围产医学杂志2019，22，7： | 2 |
| 19 | Super d-antimagic Labelings of Disconnected Plane Graphs显示文摘这份报纸处理以如此的一个方法把一张飞机图的顶点,边和脸标记,一张脸的标签和包围那张脸的顶点和边的标签总和为那张脸的重量的问题,并且所有 站在一起s 的脸的重量组成差别 d 的算术前进,为每 s ,那出现在图。纸检验如此的标记的存在为拆散飞机图的联合。 | Martin BAA Mirka MILLER Oudone PHANALASY Andrea SEMANIOV-FEOVKOV | 2010 | Acta Mathematica Sinica,English Series2010，26，12： | 2 |
| 20 | Eco-bio-social determinants of dengue vector breeding: a multicountry study in urban and periurban Asia显示文摘 | Arunachalam Natarajan Tana Susilowati Espino Fe Kittayapong Pattamaporn Abeyewickreme Wimal Wai Khin Thet Tyagi Brij Kishore Kroeger Axel Sommerfeld Johannes Petzold Max | 2010 | World Health Organization Bulletin of the World Health Organization2010，，3： | 2 |
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