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| 1 | 家族性腺瘤样息肉病中APC基因的胚系突变分析(英文)显示文摘目的探索有效的突变检测技术,系统分析家族性腺瘤样息肉病(familialadenomatouspolyposis,FAP)相关基因结肠腺瘤病(adenomatouspolyposiscoli,APC)基因的胚系突变,及其与疾病表型的关系。方法从22例临床确诊的FAP患者,外周静脉血中提取基因组DNA。变性高效液相色谱、蛋白截短检测、测序技术结合应用进行全基因分析。根据患者临床资料,进行基因型表型分析。结果22例FAP患者中13例检出APC基因胚系突变,均为无义或移码突变。基因型-表型关系的初步分析表明,在基因5′端或3′端发生突变的患者临床症状较轻,在基因中段发生突变的患者临床症状典型或严重。结论本研究中所采用的技术体系可敏感、高效地检出APC基因突变,APC基因的突变型与FAP患者的临床表型存在关联,所采用的技术体系适用于FAP症状出现前的基因诊断。 | 刘晓蓉 单祥年 Friedl W Uhlhaas S Propping P 王亚平 | 2005 | 中华医学遗传学杂志2005，22，3： | 12 |
| 2 | 错配修复基因hMLH1单核苷酸多态性T1151A在消化道肿瘤发病中的作用显示文摘在多次检出中国人大肠癌患者hMLH1基因T1151A的基础上,探讨这一单核苷酸多态性在不同人群中的存在状况及其在消化道肿瘤发病中的作用。方法:100例健康中国汉族人、80例健康日本人、100例健康德国人和109例德国人大肠癌患者、中国汉族人101例大肠癌患者、79例胃癌患者、76例食管癌患者及其胃癌和食管癌患者的亲属,取每例外周静脉血,提取基因组DNA;PCR-SSCP和DNA测序分析hMLH1基因的第12外显子。结果:hMLH1基因T1151A在中国和日本健康人群中的等位基因频率分别为3%和2.5%;与相应正常人群比较,<45岁的大肠癌患者中hMLH1基因T1151A的检出率较高(P<0.05);显著性差异还存在于具有癌症家族史的胃癌患者及其亲属与正常对照的比较(P<0.05和P<0.01);食管癌患者及其亲属与正常对照之间的比较无显著差异(P<0.05);德国人大肠癌患者和健康人群中均未检出hMLH1基因T1151A。结论:单核苷酸多态性T1151A可能是东亚人 hMLH1基因上的一个多态位点,分布具有种族差异;其存在可能与部分大肠癌、胃癌的发病有关。 | 王亚平 周建农 李金田 张军妮 李忠佑 王建东 Waltraut Friedl Peter Propping | 2001 | 外科理论与实践2001，6，1： | 8 |
| 3 | Earth observation in service of the 2030 Agenda for Sustainable Development显示文摘This paper reviews the key role that Earth Observations(EO)play in achieving the Sustainable Development Goals(SDGs)as articulated in the 2030 Agenda document and in monitoring,measuring,and reporting on progress towards the associated targets.This paper also highlights how the Group on Earth Observations(GEO)would contribute to ensure the actual use of EO in support of the 2030 Agenda;and how the Global Earth Observations System of Systems meets requirements for efficient investments in science and technology and a good return on investment,which is elaborated in the Addis Ababa Action Agenda on development financing.Through a number of examples,we first discuss how extensive EO use would:provide a substantial contribution to the achievements of the SDGs by enabling informed decision-making and by allowing monitoring of the expected results;improve national statistics for greater accuracy,by ensuring that the data are“spatially-explicit”and directly contribute to calculate the agreed SDG Targets and Indicators support the fostering of synergy between the SDGs and multilateral environmental agreements by addressing cross-cutting themes such as climate and energy;and facilitate countries’approaches for working across different development sectors,which is,according to the special adviser on the 2030 Agenda,a key challenge to achieve the SDGs.We then focus on the role that GEO could play in enabling actual use of EO in support of the 2030 Agenda by directly addressing the Strategic Development Goal 17 on partnerships. | Katherine Anderson Barbara Ryan William Sonntag Argyro Kavvada Lawrence Friedl | 2017 | Geo-Spatial Information Science2017，20，2： | 8 |
| 4 | 自愿结盟:世界贸易中多边主义与区域/双边安排的对垒显示文摘除中国外,多数亚洲国家都抛开了WTO多边规则而通过加入双边或地区自由贸易区转而支持歧视性的'自愿结盟'行为。此举明显与经济学理论相悖。考虑到由这些自由贸易区的出现而导致的多边贸易体制的碎片化以及多哈回合的举步不前,我们似乎可以感受到现实对'基本原则'回归的呼唤。由于自由贸易区数量的扩大引出的一个重要的问题,同时也是本文力图回答的一个问题是:当多边贸易体制成员方通过'自愿结盟'来解除其在多边体制下的条约义务、直接违反最惠国待遇原则,那么这个成员方是否同时也违反了《关贸总协定》规定的'目标和宗旨'以及《维也纳条约法公约》第41条。 | Friedl Weiss 李玲 | 2007 | 国际经济法学刊2007，，3： | 4 |
| 5 | Determinants of CO 2 emissions in a small open economy显示文摘 | Birgit Friedl Michael Getzner | 2003 | Ecological Economics2003，，1： | 4 |
| 6 | A kernel-driven model of effective directional emissivity for non-isothermal surfaces显示文摘Land surface temperature (LST) is a key geophysical parameter that reflects the combined effects of land surface energy and radiation balance. Remote sensing of LST, however, requires understanding the directional patterns of thermal emission from heterogeneous land surfaces. Recently, semi-empirical, linear, kernel-driven models have been successfully used to describe observed directional patterns of land surface reflectance. Following a similar methodology and based on a recent model of the physics of directional thermal emission from heterogeneous land surfaces, a kernel-driven semi-empirical model for thermal emission is developed using three kernels: (i) an isotropic kernel, corresponding to the gray-body component in a heterogeneous pixel; (ii) a two-layer canopy kernel, derived from a previous conceptual model; and (iii) a geometric optical kernel that accounts for the fact that sunlit parts are hotter than shaded parts in a pixel. The three-kernel model fits 1997 airborne directional thermal brightness data over Avignon, France, very well. | Mark FRIEDL Alan STRAHLER | 2002 | Progress in Natural Science:Materials International2002，12，8： | 4 |
| 7 | Monitoring vegetation phenology using MODIS显示文摘 | Xiaoyang Zhang Mark A. Friedl Crystal B. Schaaf Alan H. Strahler John C.F. Hodges Feng Gao Bradley C. Reed Alfredo Huete | 2002 | Remote Sensing of Environment2002，，3： | 4 |
| 8 | Monitoring vegetation phenology using MODIS显示文摘 | Xiaoyang Zhang Mark A. Friedl Crystal B. Schaaf Alan H. Strahler John C.F. Hodges Feng Gao Bradley C. Reed Alfredo Huete | 2002 | Remote Sensing of Environment2002，，3： | 2 |
| 9 | Decision tree classification of land cover from remotely sensed data显示文摘 | M.A. Friedl C.E. Brodley | 1997 | Remote Sensing of Environment1997，，3： | 2 |
| 10 | Global land cover mapping from MODIS: algorithms and early results显示文摘 | M.A Friedl D.K McIver J.C.F Hodges X.Y Zhang D Muchoney A.H Strahler C.E Woodcock S Gopal A Schneider A Cooper A Baccini F Gao C Schaaf | 2002 | Remote Sensing of Environment2002，，1： | 2 |
| 11 | Pilot trial of autologous dendritic cells loaded with tumor lysate(s)from allogeneic tumor cell lines in patients with metastatic medullary thyroidcarcinoma显示文摘 | Thomas Bachleitner-Hofmann Josef Friedl Michaela Hassler Hubert Hayden Peter Dubsky Monika Sachet Erwin Rieder Roswitha Pfragner Christine Brostjan Stefan Riss Bruno Niederle Michael Gnant Anton Stift | 2009 | Oncology Reports2009，，6： | 2 |
| 12 | The biology of cell locomotion within three-dimensional extracellular matrix显示文摘 | P. Friedl E.-B. Br?cker | 2000 | Cellular and Molecular Life Sciences2000，，1： | 2 |
| 13 | Redox flow batteries-Concepts and chemistries for cost-effective energy storage显示文摘 | Matthaa Verena HOLLAND-CUNZ Faye CORDING Jochen FRIEDL Ulrich STIMMING | 2018 | Frontiers in Energy2018，12，2： | 2 |
| 14 | Buckling phenomena related to rolling and levelling of sheet metal显示文摘 | F.D. Fischer F.G. Rammerstorfer N. Friedl W. Wieser | 2000 | International Journal of Mechanical Sciences2000，，10： | 2 |
| 15 | Maximizing land cover classification accuracies produced by decision trees at continental to global scales显示文摘 | FRIEDL M A BRODLEY C E STRAHLER A H | 1999 | IEEE Transactions on Geosciences and Remote Sensing1999，37，2： | 2 |
| 16 | Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages显示文摘 | Brunner M Moeslinger T | 2000 | Life Sci2000，68，4： | 1 |
| 17 | Tumours from MSH2 mutation carriers show loss of MSH2 expression but many tumours from MLH1 mutation carriers exhibit weak positive MLH1 staining显示文摘 | MANGOLD E PAGENSTECHER C FRIEDL W | 2005 | Pathol2005，207，4： | 1 |
| 18 | Decision tree classification of land cover from remotely sensed data显示文摘 | Friedl M A Brodeley C E | 1997 | Remote Sensing Environment1997，，61： | 1 |
| 19 | 'Une perception autre: entretien avec Bob Wilson' 显示文摘 | FRIEDL PETER | 1982 | Theatre/ Public 481982，，： | 1 |
| 20 | Spatial structure,sampling design and scale in remotely-sensed imagery of a california savanna woodland显示文摘 | McGwire K Friedl M Estes J E | 1993 | International Journal of Remote Sensing1993，14，11： | 1 |
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