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| 1 | 肥胖和动脉老化:Whitehall Ⅱ队列主动脉僵硬度纵向研究显示文摘该研究旨在确定肥胖症是否中年后动脉硬化加速的独立预测因子。纳入Whitehall Ⅱ研究受试者男性3789例,女性1383例,平均年龄66岁,均接受颈-股动脉压检测,4年后再次进行测定。一般肥胖状况由体质量指数,中心肥胖由腰围和腰臀比,脂肪含量百分比由身体阻抗来评估。通过线性混合模型,对年龄、性别、种族和平均动脉压进行调整后,所有肥胖症测量指标与主动脉硬化[通过随访的脉搏波传导速度(pulse wave velocity,PWV)较基线增加值来确定]相关。 | 刘莉 叶鹏 Brunner EJ Shipley MJ Ahmadi-Abhari S Tabak AG McEniery CM Wilkinson IB Marmot MG Singh-Manoux A Kivimaki M | 2015 | 中华高血压杂志2015，23，6： | 8 |
| 2 | Fas ligand-induced apoptosis as a mechanism of immune privilege显示文摘 | Griffith T S Brunner T Fletcher S M | | 0，，： | 2 |
| 3 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 4 | Altered expression of beta-catenin/E-cadherin in meningiomas 显示文摘 | Brunner EC Romeike BF Jung M | 2006 | Histopathology2006，49，2： | 1 |
| 5 | Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages显示文摘 | Brunner M Moeslinger T | 2000 | Life Sci2000，68，4： | 1 |
| 6 | Open reduction and fixation of medial Moore type Ⅱ fractures of the tibial plateau by a direct dorsal approach显示文摘 | Brunner A Honigmann P Horisberger M | 2009 | Arch Orthop Trauma Surg2009，129，9： | 1 |
| 7 | Scientific and clinical challenges in sepsis 显示文摘 | Ulloa L Brunner M Ramos L | 2009 | Curr Pharm Des2009，15，16： | 1 |
| 8 | Colonic spread and serum pharmacokinetics of budesonide foam in patients with mildly to moderately active ulcerative colitis显示文摘 | Brunner M Vogelsang H Greinwald R | 2005 | Aliment Pharmacol Ther2005，22，5： | 1 |
| 9 | PEGylated DNA/transferrinPEI complexes:reduced interaction with blood components,extended circulation in blood and potential for systemic gene delivery显示文摘 | Ogris M BrunnerS Schuller S | 1999 | Gene Ther1999，6，4： | 1 |
| 10 | Associations of C- reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study 显示文摘 | Gimeno D Kivimaki M Brunner EJ | 2009 | Psychol Med2009，39，3： | 1 |
| 11 | Genome-wide analysis of Aux/IAA and ARF gene families in Populus trichocarpa显示文摘 | Kalluri U C Difazio S P Brunner A M | 2007 | BMC Plant Biology2007，7，： | 1 |
| 12 | Is there an association between work stress and diurnal cortisol patterns? Findings from the White- hall II study 显示文摘 | Liao J Brunner EJ Kumari M | 2013 | PLoS One2013，8，81： | 1 |
| 13 | Phosphate oxygen isotopes:insights into sedimentary phosphorus cycling from the Benguela upwelling system显示文摘 | Goldhammer T K M Brunner B Bernasconi S M | 2011 | Geochimica et Cosmochimica Acta2011，75，13： | 1 |
| 14 | Service Management in Multi-party Active Networks 显示文摘 | Brunner M Stadler R | 2000 | IEEE Communications Magazine2000，38，3： | 1 |
| 15 | Service management multiparty active networks显示文摘 | Brunner M TIK Stadler R | 2000 | IEEE Communications Magazine2000，38，3： | 1 |
| 16 | In vitro study of ingested coins: leave them or retrieve them 显示文摘 | Rebhandl W Milassin A Brunner L Steffan I Benk T H? rmann M Burtscher J | 2007 | Pediatr Surg2007，42，10： | 1 |
| 17 | Service Management in Multi-Party Active Networks 显示文摘 | Brunner M Stadler R | 2000 | IEEE Communications Magazine2000，38，3： | 1 |
| 18 | Diagnosis of viral myocarditis by cardiac magnetic resonance and viral genome detection in peripheral blood显示文摘 | Jeserich M Brunner E Kandolf R | 2013 | The international journal of cardiovascular imaging2013，29，1： | 1 |
| 19 | Hypoxia hotspots in the Mississippi Bight显示文摘 | Brunner C A Beall J M Bentley S J | | 0，，02： | 1 |
| 20 | Classification systems for tibial plateau fractures; does computed tomography scanning improve their reliability? 显示文摘 | Brunner A Horisberger M Ulmar B | 2010 | Injury2010，41，2： | 1 |
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